Navigation Links
BU School of Medicine researcher receives Department of Defense award
Date:9/29/2010

Hasmeena Kathuria, MD, an assistant professor in the department of medicine at Boston University School of Medicine (BUSM), has received the Department of Defense Lung Cancer Promising Clinician Research Award (LCPCRA) to study the role of Ets transcription factors in the progression of lung cancer. It is hoped this research will provide important new information about the molecular progression of lung tumors and help identify new therapeutic targets to block tumor growth and metastasis. The LCPCRA supports research projects performed by promising physician-researchers.

Lung cancer is the leading cancer death in both men and women in the United States. Only about 15 percent of all lung cancer patients are alive five years after the initial diagnosis and subsequent treatments. At diagnosis, tumor cells have already left the original tumor and entered other tissue sites such as lymph nodes in about 75 percent of patients. Little is known about the factors that allow cancer cells to leave their original site of formation and move to other tissues and organs. Epithelial-mesenchymal transition (EMT), a process that involves loss of cell-cell contact and increase in cell movement, is a fundamental event in cancer spread. There is evidence suggesting that the genes and proteins to be studied in this application may be involved in several cancer-related processes but particularly those related to exit from the lung and seeding of cells into other sites.

Lkb1 kinase is a gene that is thought to protect cells from steps that cause progression to cancer cells. In lung cancer, 34 percent of human lung cancers have mutations in Lkb1 causing a loss or reduction in this function. Recently, research from the laboratory of co-investigator, Kwok-kin Wong, MD, (Dana Farber Cancer Institute) has led to the development of a mouse model of lung cancer that harbors the Lkb1 mutation and aggressively spreads to sites outside the lung. "We have identified a factor termed Ets1, along with several Ets1 target genes known to be involved in EMT such as Twist1, that are greatly increased in the mouse model compared to a mouse lung cancer model that does not harbor this mutation," explained Kathuria.

According to the researchers there is clear evidence that Ets1 is altered in lung cancer. This protein factor is a member of a family of proteins associated with other cancers. "When compared to levels of several thousand human genes in human cancers, Ets1 levels are greatly increased. This suggests that Ets1 may participate in detachment of cells, their movement out of the lung, and/or entry and growth in new sites," added Kathuria.

Therapeutic targeting of EMT activators and /or their regulators could be useful to impair EMT, and thus tumor spread. Identification of downstream pathways that are activated during EMT may reveal new diagnostic markers of early stages of lung cancer and possible novel targets for anti-metastatic therapeutics.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Team Sports Pep Up Middle-School Kids
2. NYC public school students have high levels of access to convenience stores with unhealthy food
3. Back to School Can Mean a Return to Head Lice Worries
4. Researchers will test suicide prevention program in high schools
5. Publication of World Health Report 2000 an act of remarkable courage, says school expert
6. Keeping faith -- schools must balance ethos with equality
7. Children raised by gay couples show good progress through school
8. University of Colorado Denver Business School study shows failure better teacher than success
9. UTHealth School of Nursing to host conference on aging and abuse
10. Fixing technical problems for a good nights sleep as kids start a new school year
11. Africa cell phone boom beneficial -- but schools, roads, power, water remain critical needs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson ... offers insurance and financial preparation services, is providing an update on a charitable ... , Rock City Rescue is a locally recognized nonprofit that provides shelter and ...
(Date:10/13/2017)... ... ... While it’s often important to take certain medications during the night, finding ... identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX to ... the need to turn on a light when taking medication during the night, allowing ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association of Eating ... excellence for the field of eating disorders, announces the opening of early registration ... Orlando, Florida at the Omni Resort at ChampionsGate. , The annual ...
(Date:10/13/2017)... (PRWEB) , ... October 13, ... ... School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, ... professionals on guideline updates for the primary prevention of cardiovascular diseases during ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)...  According to the Centers for Disease Control and Prevention (CDC), ... Urgent Care is helping communities across Massachusetts , ... offering no-cost* flu shots through the end of the month. ... regulations. ... a flu shot is by the end of October, according to the ...
(Date:10/2/2017)... PHILADELPHIA , Oct. 2, 2017 Halo Labs announces ... particle analysis system called the HORIZON at MIBio 2017 in ... analyzes subvisible and visible particulate matter in biopharmaceutical samples with unprecedented ... use of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/27/2017)... , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global ... that its MyDario product is expected to appear on The Dr. Oz ... Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked ... The segment features ...
Breaking Medicine Technology: