Navigation Links
BRIT1 allows DNA repair teams access to damaged sites
Date:6/19/2009

HOUSTON - Like a mechanic popping the hood of a car to get at a faulty engine, a tumor-suppressing protein allows cellular repair mechanisms to pounce on damaged DNA by overcoming a barrier to DNA access.

Reporting online at Nature Cell Biology this week, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center shows that BRIT1 connects with another protein complex to relax DNA's tight packaging at the site of the damage.

"Relaxing this barrier allows two different DNA repair pathways greater access to the damage, preventing flawed DNA from being passed on as the cell divides, which causes genomic instability leading to cancer," said senior author Shiaw-Yih Lin, Ph.D., assistant professor in M. D. Anderson's Department of Systems Biology.

BRIT1 is under-expressed in human ovarian, breast and prostate cancer cell lines. Lin and colleagues previously showed that the protein plays a key role in early detection of DNA damage.

Chromosomes are made of DNA that is tightly intertwined with proteins called histones to form chromatin. Chromatin is a very condensed structure that forms a natural barrier inhibiting access to genes, said first author Guang Peng, Ph.D., a post-doctoral fellow in Systems Biology. ATP-dependent chromatin remodeling is a fundamental mechanism used by cells to relax chromatin in DNA repair, but the detailed molecular mechanism by which it is recruited to DNA lesions in response to damage signaling has been largely unknown.

BRIT1 summons help

"Our studies demonstrate a novel mechanism by which BRIT1 recruits chromatin remodeling factors to DNA lesions to facilitate chromatin relaxation and DNA repair," Peng said.

A series of lab experiments showed that BRIT1 accomplishes this by enhanced binding to a known chromatin remodeling complex called SWI-SNF when a specific site on the complex is phosphorylated. BRIT1 also maintains the relaxat
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Donation of $15,000 and Hard Work Allows a Family in Need to Move into New Home
2. Microgrid allows simultaneous study of multiple variables
3. Computer simulator allows visually-impaired to drive
4. Perrigo Announces that Dexcels Settlement with AstraZeneca Allows OTC Omeprazole Launch Following Final FDA Approval
5. Anesthesia Pouch Allows Children to Go Home Sooner After Surgery
6. A new method allows for the early diagnosis of pulmonary hypertension
7. Mapping tool allows emergency management personnel to visually track resources
8. Elseviers "WiserWiki" Allows Physicians to Update Evidence-Based Medical Information With Experience-Based Practice Insights
9. Elseviers WiserWiki allows physicians to update evidence-based medical information
10. U.S. Patent Office Allows Significant New VNUS Patent
11. U.S. Patent Office Allows Another Significant VNUS Patent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... York, NY (PRWEB) July 31, 2014 The VitalSleep ... the lower jaw forward to help open a snorers airway to ... anti-snoring remedy helped her relationship with her husband by ... am a 46 years old. My snoring began about 15 years ... my husband and children could not sleep and had to head ...
(Date:7/31/2014)... 2014 Today, Good Neighbor Pharmacy ... patient care by kicking off another year of ... first of many education sessions and initiatives took ... Good Neighbor Pharmacy and AmerisourceBergen’s annual conference. Sessions ... (CMS) Star Measures were a highlight and helped ...
(Date:7/31/2014)... Live To Be Sober , a ... guidance, advice and program information to people who want ... drug or alcohol addiction, proudly announced today that it ... country music’s bad boy, gone good. , "NBC's The ... commented Blake, whose new single Stomp (#Stomp; available on ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Clifton Dental ... the application of topical fluoride treatments to their adult ... and help with tooth sensitivity in patients that exhibit ... an infection that is commonly known as “tooth decay” ... tissues of the teeth. , Fluoride therapy ...
(Date:7/31/2014)... a novel method for creating self-assembled protein/polymer nanostructures ... cells. The work offers a promising new way ... engineering applications. The findings were published in the ... Edition . , "We have demonstrated that, by ... form completely new types of aggregates. These aggregates ...
Breaking Medicine News(10 mins):Health News:New Snoring Mouthpiece Reviews from VitalSleep 2Health News:Good Neighbor Pharmacy Reinforces Commitment to Helping Enhance Patient Care 2Health News:Good Neighbor Pharmacy Reinforces Commitment to Helping Enhance Patient Care 3Health News:Addiction Referral Service Live To Be Sober (LiveToBeSober.com) Announces Sponsorship of Jared Blake: Country Music’s Bad Boy, Gone Good 2Health News:Addiction Referral Service Live To Be Sober (LiveToBeSober.com) Announces Sponsorship of Jared Blake: Country Music’s Bad Boy, Gone Good 3Health News:NJ Top Dentists Approved, Clifton Dental Associates Now Actively Recommending the Application of Topical Fluoride Treatments to Adults 2Health News:Carnegie Mellon chemists create nanofibers using unprecedented new method 2
... Health Tax, is the Undisclosed Premium Surcharge that Pays for ... Join the Ranks of the Uninsured, the ,Hidden Health Tax, ... in 2009WASHINGTON, May 28 The so-called "hidden ... in 2008 according to a report released today by the ...
... PhD, is the winner of the third annual Liu Young ... providing support for a young scientist on the LA BioMed ... 2005 after receiving his PhD in microbiology, immunology and molecular ... and completing a postdoctoral fellowship in tumor immunology at UCLA ...
... 28 The UltraPulse CO2 fractional laser was featured ... exciting and revolutionary new treatment for scars. During the ... as infants told their personal story and discussed recent ... treatments with the groundbreaking ActiveFX and DeepFX technologies, the ...
... platform enables payors to compete like never before ... 28 HealthEdge, provider of the only modern, ... that it will be demonstrating the award-winning HealthRules ... conference in San Diego on June 3-5. ...
... 3 to 5 hours sleep per night, study shows, , , THURSDAY, ... is getting the recommended eight hours of sleep each night. ... of highly-caffeinated energy drinks, according to new research. , And, ... polled reported falling asleep in school at least twice ...
... service to journalists and other critical audiences around ... related news releases from participating companies issued via ... for this event.(Logo: http://www.newscom.com/cgi-bin/prnh/20090417/NY00642LOGO ... http://www.newscom.com/cgi-bin/prnh/20000306/PRNLOGO )The 45th American Society ...
Cached Medicine News:Health News:'Hidden Health Tax' for Family Health Care Coverage Climbed to $1,017 in 2008 2Health News:'Hidden Health Tax' for Family Health Care Coverage Climbed to $1,017 in 2008 3Health News:Exciting Innovation in Burn Scar Treatment Using Lumenis(R) UltraPulse(R) Laser Treatments Revealed on the Today Show 2Health News:Exciting Innovation in Burn Scar Treatment Using Lumenis(R) UltraPulse(R) Laser Treatments Revealed on the Today Show 3Health News:Exciting Innovation in Burn Scar Treatment Using Lumenis(R) UltraPulse(R) Laser Treatments Revealed on the Today Show 4Health News:HealthEdge(R) to Demonstrate the Award-Winning HealthRules(R) Software Suite at AHIP Institute 2009 2Health News:Technology, Caffeine Keeping Teens Awake 2Health News:Technology, Caffeine Keeping Teens Awake 3Health News:2009 ASCO Annual Meeting and Conference News Distributed by PR Newswire Available at www.EventNewsCenter.com 2Health News:2009 ASCO Annual Meeting and Conference News Distributed by PR Newswire Available at www.EventNewsCenter.com 3
(Date:7/31/2014)... LONDON , July 31, 2014 ... for the medical industries, announced today the incorporation of genae UK ... United Kingdom has one of the largest medical device ... in 2012 and it is projected to increase by a CAGR ... billion in 2012, equal to 9.5% of GDP. Despite recessionary pressures, ...
(Date:7/31/2014)... July 31, 2014 Astellas has appointed ... corporate and employee communications in the Americas region. ... , senior vice president, chief communications officer. In ... and leading corporate brand initiatives and reputation management ... and South America . She ...
(Date:7/31/2014)... 2014 The Galien Foundation today announced the ... USA Awards. The Prix Galien Award ... the technical, scientific and clinical research skills necessary to ... brings the highest number of nominees since the inception ... Nominees include biomedical products across three categories – biotechnology, ...
Breaking Medicine Technology:genae Opens Offices in London 2Astellas Hires Industry Veteran Moyra Knight as Head of Corporate and Employee Communications 2The Galien Foundation Announces 2014 Prix Galien USA Nominees for "Best Biotechnology Product," "Best Pharmaceutical Agent," and "Best Medical Technology" 2The Galien Foundation Announces 2014 Prix Galien USA Nominees for "Best Biotechnology Product," "Best Pharmaceutical Agent," and "Best Medical Technology" 3The Galien Foundation Announces 2014 Prix Galien USA Nominees for "Best Biotechnology Product," "Best Pharmaceutical Agent," and "Best Medical Technology" 4The Galien Foundation Announces 2014 Prix Galien USA Nominees for "Best Biotechnology Product," "Best Pharmaceutical Agent," and "Best Medical Technology" 5
... , DUBLIN, Ohio , July 15 Cardinal ... LLC, expanding the company,s presence in specialty pharmaceutical services. , ... Healthcare Solutions Holding ... Pathways and P4 Healthcare. These businesses serve key participants across the ...
... , SAN MATEO, Calif. , July 15 Merz ... to doctors, offices throughout the U.S.  Previously only available in Europe ... (FDA). , , , ... study published in the June issue of Phlebology , leading experts ...
Cached Medicine Technology:Cardinal Health Completes Acquisition of Healthcare Solutions Holding 2Cardinal Health Completes Acquisition of Healthcare Solutions Holding 3Merz Aesthetics™ Asclera™ (polidocanol) Injection Now Available in Doctors' Offices Nationwide 2Merz Aesthetics™ Asclera™ (polidocanol) Injection Now Available in Doctors' Offices Nationwide 3Merz Aesthetics™ Asclera™ (polidocanol) Injection Now Available in Doctors' Offices Nationwide 4
Contoured waterfall-front ergonomic seats and generous backrests with lumbar support are standard on these ergonomic chairs. • With casters • With Tubular Base....
Contoured waterfall-front ergonomic seats and generous backrests with lumbar support are standard on these ergonomic chairs. • With casters • With Tubular Base....
... Bench high, 26-31". Ergonomic design increases ... pnuematic control for easy height adjustment. ... allow easy mobility. Fixed footring standard. ... 5000 Volts to technical zero); ...
Inquire...
Medicine Products: