Navigation Links
BRCA test results affect patients' breast cancer surgery plans
Date:6/13/2014

PROVIDENCE, R.I. [Brown University] Women diagnosed with breast cancer often face a crucial decision about the extent of their surgical treatment. Many meet national guidelines recommending testing for mutations in the BRCA 1 and 2 genes, which carry a substantial risk of future cancer. A new study reports that among women with breast cancer who undergo recommended testing before surgery, more than 7 in 10 who test positive will change their surgical plan, typically opting for a more extensive procedure such as a double mastectomy and sometimes ovary removal.

"As soon as somebody hears they have a 65 percent chance of a new breast cancer in the future or an up to 60 percent chance of ovarian cancer, they are likely to do whatever they can to prevent that," said lead author Dr. Elizabeth Lokich, an obstetrics and gynecology fellow in the Warren Alpert Medical School of Brown University and at Women & Infants Hospital.

The study appears online in the journal Gynecological Oncology with the recommendation that women who meet National Comprehensive Cancer Network guidelines for genetic testing get the test before deciding on their surgery.

"Particularly because of what we found that it changes their surgical planning it really makes the most sense to have this evaluation done pre-operatively," Lokich said.

The study was based on a retrospective review of the records of 302 Women & Infants breast cancer patients who had undergone preoperative genetic testing between 2006 and 2012 because they met the NCCN guidelines. Within that group, 32 learned that they carried a mutation in their BRCA1 or BRCA2 genes. With that information, 71.9 percent, or 23, of the women who tested positive changed their surgical plan compared to only 28.9 percent of women who tested negative.

Among the mutation carriers, 31.3 percent chose lumpectomies, while 59.4 percent chose double mastecto
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New therapy for pancreatic cancer patients shows promising results
2. Long-term results encouraging for combination immunotherapy for advanced melanoma
3. Immune therapy for advanced bladder cancer yields promising results
4. EORTC to present cancer research results at ASCO 2014
5. Clinicians urged to consider spironolactone in HFPEF despite TOPCAT results
6. Ataluren Phase 3 trial results in nonsense mutation cystic fibrosis
7. Vibrating capsule shows promising results in treating chronic constipation
8. Automated link to national intervention guidance helps doctors interpret FRAX results
9. Real-world heart procedure results consistent with scientific research
10. Resin infiltration effects in a caries-active environment -- 2 year results
11. Reducing RT dose to bilateral IB lymph nodes results in better patient-reported salivary function
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
BRCA test results affect patients' breast cancer surgery plans
(Date:7/23/2014)... of research suggesting a safe and effective role ... cancer, with fewer detrimental side effects and improved ... study will be published in final format today ... Endocrinology . , Breast cancer is the most ... States. Approximately 70% of breast cancers are diagnosed ...
(Date:7/23/2014)... July 23, 2014 Rich Dad® Education, a ... of their charity yard sale to support Habit for Humanity ... 100% of the proceeds will be donated to Habitat for ... are being donated to the Habitat for Humanity ReStore thrift ... 33903. , One of the highlights of the yard ...
(Date:7/23/2014)... York (PRWEB) July 23, 2014 Thousands ... to move forward in a federal multidistrict litigation underway ... Liebhard LLP reports. According to an Order dated July ... hospital’s bid for payment of a $1,000 fee for ... implant. , Among other things, the Order noted ...
(Date:7/23/2014)... better treating the pernicious disorders of obesity and dementia ... American University,s Center for Behavioral Neuroscience. In the paper, ... aimed at areas of the brain responsible for memory ... could play a role in reducing certain dementias., "In ... measures often fall short. This is a new way ...
(Date:7/23/2014)... Olympic gold medal-winning speed skater Chad ... Friday, July 18. Hedrick visited Roanoke as the special ... an Olympic-style event celebrating its 25th Anniversary in 2014. ... premier sponsor of the Commonwealth Games, which like Foot ... and all activity levels. , Hedrick, a native of ...
Breaking Medicine News(10 mins):Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5Health News:Rich Dad Education Charity Yard Sale Raises Over $650 for Habitat for Humanity of Lee and Hendry Counties 2Health News:DePuy Pinnacle Hip Lawsuits Move Forward, as Federal Judge Denies Hospital Bid for $1000 Explant Fee, Bernstein Liebhard LLP Reports 2Health News:DePuy Pinnacle Hip Lawsuits Move Forward, as Federal Judge Denies Hospital Bid for $1000 Explant Fee, Bernstein Liebhard LLP Reports 3Health News:DePuy Pinnacle Hip Lawsuits Move Forward, as Federal Judge Denies Hospital Bid for $1000 Explant Fee, Bernstein Liebhard LLP Reports 4Health News:Targeting the brain to treat obesity 2Health News:Targeting the brain to treat obesity 3Health News:US Olympian Chad Hedrick Visits Foot Levelers 2
... , ... Care of Serious Illness is the first book to provide a comprehensive look at the ... E. Meier, Stephen L. Isaacs, Robert Hughes (Editors) , ... New York, NY (Vocus) April 1, 2010 -- Palliative Care: Transforming ...
... they know how cytomegalovirus continues to re-infect people , THURSDAY, ... how a virus known as cytomegalovirus (CMV), which infects up ... re-infects people again and again even though their immune systems ... always make people ill, but certain people, such as newborns ...
... SNM and the Radiological Society of North America (RSNA) ... at the Natcher Conference Center of the National Institutes ... workshop will focus on general issues of standardization to ... and analysis of images in clinical trials. The second ...
... beat vitamin B for those with scent-robbing viral infection, ... Acupuncture may help people who lose their sense of ... a new study, 15 patients with post-viral olfactory dysfunction ... acupuncture. These patients were compared with PVOD patients treated ...
... new study of brain activity in depressed and anxious people ... modified for better or for worse by anxiety. ... Behavioral Neuroscience , looked at depression and two types of ... panic; and anxious apprehension, better known as worry. The ...
... ... Mac platforms , ... Richardson, TX (PRWEB) April 1, 2010 -- Damaka, a technology pioneer in Mobile ... Real-time 2-way Video, Application Sharing) Sweeping™ between laptops and mobile devices earlier in May ...
Cached Medicine News:Health News:Palliative Care: Transforming the Care of Serious Illness 2Health News:Palliative Care: Transforming the Care of Serious Illness 3Health News:Demystifying a Common, Persistent Virus 2Health News:FDA, SNM and RSNA host April 13-14 two-topic imaging workshop 2Health News:Depressed? Fearful? It might help to worry, too 2Health News:Damaka Delivers Advanced Sweeping™ Capability of Live Sessions Across Multiple Devices Over WiFi, 3G and 4G Networks 2
(Date:7/23/2014)... July 23, 2014 PositiveID Corp. (OTCQB: PSID), ... , is an emerging player in the bio-threat ... bio-threat detection and rapid medical testing. The Company,s ... Bio-agent Autonomous Networked Detector), was developed under contract ... Science & Technology directorate, and $30 million of ...
(Date:7/23/2014)... Research and Markets has announced the addition ... Markets Worldwide 2014" report to their offering. ... purpose of this report is to analyze and size ... Gloves. The report discusses key players and identifies trends ... covered include product definitions, strategies, competitive analysis, market shares, ...
(Date:7/23/2014)... , July 23, 2014  The management team ... ) will hold a conference call on July ... second quarter ended June 30, 2014.  The call ... 2014Time: , 8:30 am EDTDial-in numbers: , Toll ... (412) 317-0790Webcast (live & archive): , www.columbialabs.com ...
Breaking Medicine Technology:PositiveID Analyst Inspection: Emerging Contender in BioThreat Detection - First Ever Revenue Guidance and Backlog Position Company for Increased Visibility and Traction - by SmallCapTraders.com 2Disposable Medical Gloves (Exam and Surgical) Markets Worldwide 2014 2Disposable Medical Gloves (Exam and Surgical) Markets Worldwide 2014 3Disposable Medical Gloves (Exam and Surgical) Markets Worldwide 2014 4Columbia Laboratories to Discuss Second Quarter 2014 Financial Results on July 31st Conference Call 2
... MAQUET Cardiovascular LLC today announced the launch ... VASOSHIELD Pressure Controlling Syringe for use during Coronary Artery ... "flushing" pressure and controls vessel distension when harvested grafts ... Avoiding excessive pressure and limiting distension help maintain internal ...
... N.J. , May 3 Covance Inc. (NYSE: CVD ... Health Care Conference on Tuesday, May 4, 2010 at 1:30 ... www.covance.com .  In order to register and download any necessary software, please ... , Covance, ...
Cached Medicine Technology:MAQUET Cardiovascular Introduces New VASOSHIELD Pressure Controlling Syringe to Help Preserve Graft Integrity for Coronary Artery Bypass Surgery Patients 2MAQUET Cardiovascular Introduces New VASOSHIELD Pressure Controlling Syringe to Help Preserve Graft Integrity for Coronary Artery Bypass Surgery Patients 3MAQUET Cardiovascular Introduces New VASOSHIELD Pressure Controlling Syringe to Help Preserve Graft Integrity for Coronary Artery Bypass Surgery Patients 4
Full plate covers seal all 24 MicroAmp tubes...
96-Well PCR Plate Sealing Mat...
Easy to pierce, remove using foil stripper...
Inquire...
Medicine Products: