Navigation Links
BRAF addiction of thyroid cancers makes them therapeutically vulnerable
Date:11/21/2011

Papillary carcinoma is the most common form of thyroid cancer. Approximately one quarter of these carcinomas have mutations in the BRAF gene. The prevalence of such mutations is even greater in high-grade carcinomas, particularly those that are refractory to standard treatment, which is radioactive iodine (RAI). A team of researchers led by James Fagin, at Memorial Sloan-Kettering Cancer Center, New York, has now identified a way to potentially exploit the expression of BRAF by such cancers for therapeutic purposes.

Despite the prevalence of BRAF mutations in papillary carcinoma it has remained unclear how dependent thyroid cancers are on BRAF expression. Fagin and colleagues first showed that thyroid tumors in mice expressing one of the most commonly detected BRAF mutations in human papillary thyroid carcinomas were exquisitely dependent on BRAF for viability. Of therapeutic significance, treating thyroid tumorbearing mice with drugs that inhibited the BRAF signaling pathway rendered the tumor cells susceptible to a therapeutic dose of RAI. Fagin and colleagues therefore suggest that their data provide rationale for clinical trials testing whether such drugs can restore the efficacy of RAI therapy in patients with papillary thyroid carcinomas expressing BRAF mutations.


'/>"/>
Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Helping others helps teens stay on the road to addiction recovery
2. Suboxone is most effective in treating painkiller addiction
3. Study shows young adults want to recover from addiction but need help to make it happen
4. Quitting Even Tougher When Smokers Battle Other Addictions
5. When Teens Abuse Prescriptions, Addiction Often Follows
6. Successful lab tests on a potential vaccine for heroin addiction
7. Addiction Starts Early in American Society, Report Finds
8. Altruistic decision making focus of NIDAs Addiction Science Award
9. NIDA raises the curtain on addiction
10. Coffee Addiction May Be Grounded in Genes
11. Compulsive Eaters May Have Food Addiction, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... integration of the CareFusion NOX-T3 portable sleep monitor with its Somnoware Sleep Device ... consistent, browser-based interface for diagnostic device operations. With this platform, initializing devices and ...
(Date:5/26/2017)... ... May 26, 2017 , ... On May 24, the Congressional ... passed the U.S. House on May 4, would result in 23 million Americans losing ... implementation of the 2010 Patient Protection and Affordable Care Act (ACA). , “It ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... Rob Lowe ... An upcoming production of the series is on hiking in American. Viewers can reconnect ... of the great benefits of hiking. , Many consumers have looked for an inventive ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... be this year’s recipient of proceeds from its 14th Annual Clays for Kids ... E. County Road 30, Bennett, Colorado. , As part of BluSky’s partnership ...
(Date:5/24/2017)... ... 24, 2017 , ... Last month, representatives from Rendina Healthcare ... town officials to celebrate the grand opening of the 87,000 square foot medical ... of its ongoing relationship with RWJBarnabas Health, New Jersey’s largest health system. Two ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of the ... based on extensive data analysis from GHI,s hospitals database ... database for the region. The GHI database covers 86% of ... more than 130 data points for each institution in key ...
(Date:5/9/2017)... 9, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... today announced it has earned a spot on ... The Company was ranked among 500 U.S. employers as ... Healthcare Equipment and Services. The annual ... anonymous, independent survey of over 30,000 employees across 25 ...
(Date:5/8/2017)... YORK , May 8, 2017 ... the transition from fee for service reimbursement. Black Book ... 2017. 1.       The Market for MIPS ... 77% of physician practices with 3 or more ... Technology Solutions by Q4. "Given the magnitude of the ...
Breaking Medicine Technology: