Navigation Links
BPA exposure in utero may increase predisposition to breast cancer
Date:10/3/2011

Chevy Chase, MDA recent study accepted for publication in Molecular Endocrinology, a journal of The Endocrine Society, found that perinatal exposure to environmentally relevant doses of bisphenol A (BPA) alters long-term hormone response and breast development in mice that may increase the propensity to develop cancer.

BPA, a man-made chemical produced and marketed largely for specific industrial purposes, is detected in body fluids of more than 90 percent of the human population. It was originally synthesized as an estrogenic compound and there has been concern that exposure to BPA could have developmental effects on various hormone-responsive organs including the mammary gland.

"I want it to be clear that we do not provide evidence that BPA exposure causes breast cancer per se," said Cathrin Brisken, MD, of the Swiss Institute for Experimental Cancer Research and co-author of the study. "We do provide evidence that BPA exposure alters mammary gland development and that this may increase the predisposition of the breast to breast cancer."

In this study, researchers mimicked human exposure to BPA as it occurs with beverages and food from BPA containing vessels (such as plastics and the lining of tin cans) by adding the compound to the drinking water of breeding mice. Female pups born from BPA-consuming parents were transferred to a BPA-free environment at weaning and followed over time.

Researchers analyzed changes in the mammary gland of female offspring that were exposed to BPA through their mothers in utero and while being breast fed. The mammary glands of BPA exposed females showed an increased response to the hormone progesterone. Lifetime exposure to progesterone has been linked to increase breast cancer risk.

Furthermore, researchers found that adult females who had been exposed to BPA in utero and while breast fed, showed a 1.5 fold increase in cell numbers in their milk ducts. This is comparable to what
'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mayo Clinic study: multiple surgeries and anesthesia exposure
2. Prenatal exposure to phthalates linked to decreased mental and motor development
3. Nurses at Risk for Accidental Exposure to Chemo Drugs: Study
4. Short latencies shown for cancer in young workers with exposures to electro-magnetic fields
5. Prenatal pet exposure, delivery mode, race are key factors in early allergy risk
6. Fetal Exposure to Magnetic Fields From Appliances, Power Lines May Up Kids Asthma Risk
7. UCI-led study links prenatal exposure to stress with accelerated cell aging
8. Exposure to Common Chemicals May Affect Thyroid Function
9. Fetal Exposure to Common Epilepsy Drugs May Harm Kids IQ: FDA
10. On-the-Job Lead Exposures Falling, But Still a Problem: CDC
11. Exposure to parental stress increases pollution-related lung damage in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... Los Angeles, CA (PRWEB) July 22, 2014 ... leads the way in providing resources, educational tools and ... that tell the stories of prevention, treatment and recovery. ... drama BLACK BOX will spotlight some of these resources ... Mental Health Services Administration helpline and treatment website at ...
(Date:7/22/2014)... The market for botulinum neurotoxin (BoNT) products has ... novel medical indications created and due to more cosmetic ... physical appearance is extremely valued. Although the BoNT market ... companies and technologies are setting ground for biosuperiors and ... price of 1st-gen products under pressure, only innovation is ...
(Date:7/22/2014)... Doheny HealthDay Reporter TUESDAY, ... a minimally invasive procedure known as morcellation carries a risk ... the likelihood more clearly. Twenty-seven of every 10,000 women ... time of the procedure, researchers found, with the odds being ... performing a hysterectomy with morcellation use a power cutter to ...
(Date:7/22/2014)... French . ... to step out for a cigarette twice as often as ... those who have the hardest time shaking off the habit ... aware of. , Those insights were among the collective findings ... by a team of researchers based in part at ...
(Date:7/22/2014)... 5i Sciences, a medical technology company focused ... Coye, M.D., M.P.H. to a role as Senior Consultant. ... the market introduction of innovative technologies that impact healthcare ... on strategies for building a successful commercial healthcare enterprise ... Coye is currently the Chief Innovation Officer of UCLA ...
Breaking Medicine News(10 mins):Health News:ABC’s BLACK BOX Spotlights Mental Health and Available Resources in Upcoming Episode 2Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 2Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 3Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 4Health News:Technique Used in Some Hysterectomies May Help Spread Cancer: Study 2Health News:Technique Used in Some Hysterectomies May Help Spread Cancer: Study 3Health News:Extra exercise helps depressed smokers kick the habit faster 2Health News:5i Sciences Announces Appointment of a Senior Healthcare Consultant and Successful Financing 2
... The Michael J. Fox,Foundation (MJFF) for Parkinson,s Research ... effort. Under this annual program the Foundation,will award ... designed to validate the,therapeutic potential of scientific discoveries, ... investment and clinical trials., "Target Validation is ...
... cells in the liver, allowing steatosis (simple fatty liver) ... to the results of a new study in the ... Wiley & Sons on behalf of the American Association ... is also available online at Wiley Interscience (http://www.interscience.wiley.com/journal/hepatology). , ...
... Carrington,Laboratories, Inc. (OTC Bulletin Board: CARN) today ... present,at the Acumen BioFin Rodman & Renshaw 9th ... pm Eastern Time at the New York Palace,Hotel. ... technologies in the,areas of drug delivery and vaccine ...
... NEW YORK, Nov. 1 Fibromyalgia is the ... States, affecting more than,six million Americans. But, findings ... Association (NFA) show there is still much to ... of the general public shows nearly half (45%) ...
... ... Services, DALLAS, Nov. 1 ... the largest gift in the,institution,s 80-year history. The Schenkels, gift today represents ... Schenkels, $4 million gift, the fund now tops the $50,million mark. ...
... is common in children with heart disease, a population ... , More than 25 percent of children with ... say researchers from The Childrens Hospital of Philadelphia and ... current issue of Pediatrics. While this 25 percent prevalence ...
Cached Medicine News:Health News:Michael J. Fox Foundation Commits Up to $2 Million for PD Drug Development Under Target Validation 2008 2Health News:High-fat diet makes mice susceptible to liver injury 2Health News:Carrington Subsidiary DelSite to Present at Investor Conference 2Health News:Medialink Features: The Painful Truth About Fibromyalgia 2Health News:Methodist Health System Foundation Announces Largest Single Gift 2Health News:Methodist Health System Foundation Announces Largest Single Gift 3Health News:Methodist Health System Foundation Announces Largest Single Gift 4Health News:Obesity common in children with heart disease 2
(Date:7/22/2014)... Research and Markets has announced the addition ... Reagent, by Application - Global Forecast to 2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Biopharmaceuticals are pharmaceutical products isolated ... most important and widely used techniques for biopharmaceutical production. ... cell culture market in 2013. Growth in the biopharmaceutical ...
(Date:7/22/2014)... According to a new ... (Technology Types - Near infrared (NIR) spectroscopy, Raman spectroscopy and ... Size, Share, Growth, Trends and Forecast, 2013 - 2019," the ... is expected to grow at a CAGR of 7.4% from ... was the largest contributor to global process spectroscopy market ...
(Date:7/22/2014)... 2014 BiologicTx ® today announced their ... Kidney Paired Donation transplant exchange utilizing BiologicTx,s proprietary matching ... 9 at the Miami Transplant Institute, located at Jackson ... Kidney Paired Donation (KPD) is an ... kidney transplant with one another due to incompatible blood ...
Breaking Medicine Technology:Global Cell Culture (Bioreactor, Incubator, Centrifuge) Market - Forecast to 2018 2Global Cell Culture (Bioreactor, Incubator, Centrifuge) Market - Forecast to 2018 3Process Spectroscopy Market Expected to Reach USD 1,179.6 Million in 2019: Transparency Market Research 2Process Spectroscopy Market Expected to Reach USD 1,179.6 Million in 2019: Transparency Market Research 3Process Spectroscopy Market Expected to Reach USD 1,179.6 Million in 2019: Transparency Market Research 4BiologicTx Paired Donation Aids In Successful Kidney Transplants 2BiologicTx Paired Donation Aids In Successful Kidney Transplants 3
... July 12, 2011 Sevocity, the leader in ... v11.1 has achieved full certification through the Certification ... a CCHIT Certified® 2011 Ambulatory EHR.  Sevocity v11.1 ... the highest level awarded by CCHIT.  The Certification ...
... 12, 2011 ,   ... are,pleased to announce that they have been engaged ... apricitabine (ATC), a late-stage,novel treatment for HIV infection. ... the,healthcare and investment business sectors. Dr ...
Cached Medicine Technology:Sevocity Division of Conceptual MindWorks Inc.'s Sevocity EHR Earns CCHIT 2011 Certification 2PharmaVentures Engaged by Avexa to Assist in the Out-licensing of Apricitabine 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: