Navigation Links
BPA exposure in utero may increase predisposition to breast cancer
Date:10/3/2011

Chevy Chase, MDA recent study accepted for publication in Molecular Endocrinology, a journal of The Endocrine Society, found that perinatal exposure to environmentally relevant doses of bisphenol A (BPA) alters long-term hormone response and breast development in mice that may increase the propensity to develop cancer.

BPA, a man-made chemical produced and marketed largely for specific industrial purposes, is detected in body fluids of more than 90 percent of the human population. It was originally synthesized as an estrogenic compound and there has been concern that exposure to BPA could have developmental effects on various hormone-responsive organs including the mammary gland.

"I want it to be clear that we do not provide evidence that BPA exposure causes breast cancer per se," said Cathrin Brisken, MD, of the Swiss Institute for Experimental Cancer Research and co-author of the study. "We do provide evidence that BPA exposure alters mammary gland development and that this may increase the predisposition of the breast to breast cancer."

In this study, researchers mimicked human exposure to BPA as it occurs with beverages and food from BPA containing vessels (such as plastics and the lining of tin cans) by adding the compound to the drinking water of breeding mice. Female pups born from BPA-consuming parents were transferred to a BPA-free environment at weaning and followed over time.

Researchers analyzed changes in the mammary gland of female offspring that were exposed to BPA through their mothers in utero and while being breast fed. The mammary glands of BPA exposed females showed an increased response to the hormone progesterone. Lifetime exposure to progesterone has been linked to increase breast cancer risk.

Furthermore, researchers found that adult females who had been exposed to BPA in utero and while breast fed, showed a 1.5 fold increase in cell numbers in their milk ducts. This is comparable to what is seen upon similar exposure to another estrogenic compound, diethyllbestrol (DES). Uterine exposure to DES in the human population has been shown to increase the relative risk of getting breast cancer two-fold as women reach their fifties.

"While we cannot extrapolate these results directly from mice to humans, the possibility that some of the increase in breast cancer incidence observed over the past decades may be attributed to exposure to BPA cannot be dismissed," said Brisken. "Our study suggests that pregnant and breastfeeding mothers should avoid exposure to BPA as it may affect their daughters' breast tissue."


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Mayo Clinic study: multiple surgeries and anesthesia exposure
2. Prenatal exposure to phthalates linked to decreased mental and motor development
3. Nurses at Risk for Accidental Exposure to Chemo Drugs: Study
4. Short latencies shown for cancer in young workers with exposures to electro-magnetic fields
5. Prenatal pet exposure, delivery mode, race are key factors in early allergy risk
6. Fetal Exposure to Magnetic Fields From Appliances, Power Lines May Up Kids Asthma Risk
7. UCI-led study links prenatal exposure to stress with accelerated cell aging
8. Exposure to Common Chemicals May Affect Thyroid Function
9. Fetal Exposure to Common Epilepsy Drugs May Harm Kids IQ: FDA
10. On-the-Job Lead Exposures Falling, But Still a Problem: CDC
11. Exposure to parental stress increases pollution-related lung damage in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... ... September 19, 2017 , ... Trusted debt-reduction firm CreditAssociates, LLC has announced two ... in excess of $835 million in resolved debt for its clients. , Credit card ... of the categories of debt settled by the company. With more than a decade ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... Canyon Ranch to its recently formed Corporate Roundtable, a group of ... system and a sustainable world. , Canyon Ranch is a unique collection of ...
(Date:9/19/2017)... RESTON, VA (PRWEB) , ... ... ... future of medication management to the present, Mirixa Corporation recently unveiled the ... has continually redefined and reinvented how medication management services are delivered. Based ...
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... Driving Dynamics ... Safety Training Company by Training Industry Inc. as part of its mission to continually ... , Selection to the first annual 2017 Top 20 Health and Safety Training Companies ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... neurosurgeon, has received a big bump in sales after recently going live ... available on the Wal-Mart Stores-owned Jet.com, StackedNutrtion.com, RonnieColemanNutrition.com, RevNutrition.com and Go4ItNutrition.com. ...
Breaking Medicine News(10 mins):
(Date:8/29/2017)... 2017 ivWatch, LLC, the leading provider of continuous monitoring ... has been awarded an Innovative Technology contract from Vizient, Inc., the ... ... in the early detection of peripheral IV infiltration and extravasation events ... The Innovative Technology contract was awarded to ...
(Date:8/28/2017)... division of LightScalpel ®, LLC, is announcing its new line of ... American veterinary laser surgery innovation, Aesculight® is revolutionizing veterinary laser surgery once ... ... VetScalpel laser. Dr. Duclos practices veterinary dermatology at the Animal Skin and ... ...
(Date:8/24/2017)... -- BioBridges, a Career Portfolio® Management company providing integrated ... announce its corporate sponsorship of the upcoming fourth annual ... event will benefit charitable foundations affiliated with each band. ... to return once again as a sponsor of the ... Jason Falchuk , BioBridges Founding Partner. "Our life sciences ...
Breaking Medicine Technology: