Navigation Links
BPA exposure in utero may increase predisposition to breast cancer
Date:10/3/2011

Chevy Chase, MDA recent study accepted for publication in Molecular Endocrinology, a journal of The Endocrine Society, found that perinatal exposure to environmentally relevant doses of bisphenol A (BPA) alters long-term hormone response and breast development in mice that may increase the propensity to develop cancer.

BPA, a man-made chemical produced and marketed largely for specific industrial purposes, is detected in body fluids of more than 90 percent of the human population. It was originally synthesized as an estrogenic compound and there has been concern that exposure to BPA could have developmental effects on various hormone-responsive organs including the mammary gland.

"I want it to be clear that we do not provide evidence that BPA exposure causes breast cancer per se," said Cathrin Brisken, MD, of the Swiss Institute for Experimental Cancer Research and co-author of the study. "We do provide evidence that BPA exposure alters mammary gland development and that this may increase the predisposition of the breast to breast cancer."

In this study, researchers mimicked human exposure to BPA as it occurs with beverages and food from BPA containing vessels (such as plastics and the lining of tin cans) by adding the compound to the drinking water of breeding mice. Female pups born from BPA-consuming parents were transferred to a BPA-free environment at weaning and followed over time.

Researchers analyzed changes in the mammary gland of female offspring that were exposed to BPA through their mothers in utero and while being breast fed. The mammary glands of BPA exposed females showed an increased response to the hormone progesterone. Lifetime exposure to progesterone has been linked to increase breast cancer risk.

Furthermore, researchers found that adult females who had been exposed to BPA in utero and while breast fed, showed a 1.5 fold increase in cell numbers in their milk ducts. This is comparable to what is seen upon similar exposure to another estrogenic compound, diethyllbestrol (DES). Uterine exposure to DES in the human population has been shown to increase the relative risk of getting breast cancer two-fold as women reach their fifties.

"While we cannot extrapolate these results directly from mice to humans, the possibility that some of the increase in breast cancer incidence observed over the past decades may be attributed to exposure to BPA cannot be dismissed," said Brisken. "Our study suggests that pregnant and breastfeeding mothers should avoid exposure to BPA as it may affect their daughters' breast tissue."


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Mayo Clinic study: multiple surgeries and anesthesia exposure
2. Prenatal exposure to phthalates linked to decreased mental and motor development
3. Nurses at Risk for Accidental Exposure to Chemo Drugs: Study
4. Short latencies shown for cancer in young workers with exposures to electro-magnetic fields
5. Prenatal pet exposure, delivery mode, race are key factors in early allergy risk
6. Fetal Exposure to Magnetic Fields From Appliances, Power Lines May Up Kids Asthma Risk
7. UCI-led study links prenatal exposure to stress with accelerated cell aging
8. Exposure to Common Chemicals May Affect Thyroid Function
9. Fetal Exposure to Common Epilepsy Drugs May Harm Kids IQ: FDA
10. On-the-Job Lead Exposures Falling, But Still a Problem: CDC
11. Exposure to parental stress increases pollution-related lung damage in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... certification process to promote standards of excellence for the field of eating disorders, ... March 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Lori R. ... a member of ElderCounsel, a national organization of elder law and special needs planning ... laws and rules. It also provides a forum to network with elder law attorneys ...
(Date:10/13/2017)... ... , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to ... unique items from across the nation, this holiday-themed event will raise funds and awareness ... VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... CAESAREA, Israel and NEW YORK , Sept. ... company with mobile health and big data solutions, today announced that its ... today. Please check your local TV listings for when The Dr. Oz ... ... ninth season this month. ...
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
(Date:9/13/2017)... OrthoAtlanta has been named the official orthopedic and sports ... the 2018 College Football Playoff (CFP) National Championship to be ... Atlanta, Georgia . OrthoAtlanta is proud to ... in many activities leading up to, and including the national ... OrthoAtlanta ...
Breaking Medicine Technology: