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BPA alters development of in vitro ova and could increase risk of Down syndrome
Date:9/21/2011

models, while the effects on meiotic recombination, which could lead to the appearance of Down Syndrome, in humans are even greater than those observed in mice.

"According to our results, BPA does not directly affect the fertility of pregnant women, but that of their daughters and granddaughters. It is a multigenerational effect", explains UAB professor Montserrat Garcia Calds, director of the research. She goes on to say that "the increase in oocyte mortality in the fetus could diminish ovarian reserve numbers and the quality of the future mother's ova. At the same time, alterations in the recombination of chromosomes in the process of cell division increase the possibility of numerical alterations, such as monosomy (only copy of a chromosome in embryo cells) or trisomy (three copies)."

Concentration levels applied in the experiments were within the safety limits marked by European (EFSA) and US (EPA) authorities. The research therefore suggests that staying within legal limits does not imply that exposure to the substance is innocuous.

"We are exposed to BPA on a daily basis, mainly through oral exposure, since we can find it in lunch boxes, beverage bottles and food storage containers", Miguel ngel Brieo-Enrquez reminds us. First author of the article, Brieo-Enrquez, from the University of San Luis Potos, Mexico, is now researcher at the UAB Department of Cell Biology, Physiology and Immunology. According to him, "although we generally metabolise the substance, pregnant women retain more fluids and the fetus could be affected by high concentration levels."


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Contact: Montserrat Garcia Caldes
Montserrat.garcia.caldes@uab.cat
34-935-811-905
Universitat Autonoma de Barcelona
Source:Eurekalert

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