BIG research offers insight into aging -- 2 scientists awarded $200...(effects of long-term CR in humans on gen...),Health

Date:8/13/2009

effects of long-term CR in humans on gene function modifications, which may be involved in mediating some of the longevity results. Dr. Fontana will study whether long-term CR with adequate protein and micronutrients intake results in some of the same changes in gene function that have been shown in calorically restricted mice and monkeys. By elucidating the molecular mechanisms underlying the effects of CR in humans, Dr. Fontana's research may identify potential biomarkers of aging and longevity that could assist clinicians in predicting many different age-associated diseases in humans.

"We created the BIG award to encourage scientists to engage in bolder research pursuits, those that are higher-risk but which offer the potential for greater reward in our understanding of basic mechanisms that affect aging and age-related diseases," said Mark R. Collins, president of the Glenn Foundation for Medical Research. "Our hope is that these awards will lead to new insights into the molecular factors that coordinate aging in multiple cells and tissues," he added.

"The BIG program is a novel approach to funding science that rewards innovative thinking, which may ultimately increase the odds that we will all live healthier for a much longer period of time," said Stephanie Lederman, executive director, American Federation for Aging Research.

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Contact: Stacey Harris Stacey@afar.org 212-703-9977 American Federation for Aging Research Source:Eurekalert

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