Navigation Links
BIG research offers insight into aging -- 2 scientists awarded $200,000 prize
Date:8/13/2009

NEW YORK, August 12, 2009 -- Rochelle Buffenstein, PhD, professor, University of Texas Health Science Center at San Antonio and Luigi Fontana, MD, PhD, research associate professor, Washington University in St. Louis, were selected as recipients of the Breakthroughs in Gerontology (BIG) Award sponsored by the Glenn Foundation for Medical Research and the American Federation for Aging Research (AFAR). Established in 2005, the BIG Award provides $200,000 grants for high risk, original research that offers significant promise of yielding transforming discoveries in the fundamental biology of aging.

Dr. Buffenstein will investigate how regulation by the Nrf2 signaling pathwaya major detoxification pathwayprotects long-lived species such as the naked mole rat from cellular stress that contributes to age-related diseases. The naked mole rat is the longest-lived rodent known, living 8.6 times longer than similar-sized mice, and maintains cancer-free, good health for more than 85% of its 30-year lifespan. Its tissues show pronounced cellular resistance to most noxious agents. In contrast, most short-lived species, rather than fending off threats to their tissues, direct many of their resources into rapid growth and early reproduction and readily succumb to age-related diseases such as cancer. Understanding the mechanisms involved in this pathway may provide pivotal insights into aging.

Dr. Fontana seeks to better understand caloric restriction (CR), which has been shown to slow aging in certain laboratory animals. The precise molecular mechanisms responsible for this effect are not known, but likely involve the regulation of gene function. Recent findings in individuals on long-term CR with adequate nutrition observed protection against diabetes, hypertension, inflammation, clogged arteries and deterioration of heart function with aging. This is consistent with long-term effects of CR in monkeys and rodents. However, little is known about the effects of long-term CR in humans on gene function modifications, which may be involved in mediating some of the longevity results. Dr. Fontana will study whether long-term CR with adequate protein and micronutrients intake results in some of the same changes in gene function that have been shown in calorically restricted mice and monkeys. By elucidating the molecular mechanisms underlying the effects of CR in humans, Dr. Fontana's research may identify potential biomarkers of aging and longevity that could assist clinicians in predicting many different age-associated diseases in humans.

"We created the BIG award to encourage scientists to engage in bolder research pursuits, those that are higher-risk but which offer the potential for greater reward in our understanding of basic mechanisms that affect aging and age-related diseases," said Mark R. Collins, president of the Glenn Foundation for Medical Research. "Our hope is that these awards will lead to new insights into the molecular factors that coordinate aging in multiple cells and tissues," he added.

"The BIG program is a novel approach to funding science that rewards innovative thinking, which may ultimately increase the odds that we will all live healthier for a much longer period of time," said Stephanie Lederman, executive director, American Federation for Aging Research.


'/>"/>

Contact: Stacey Harris
Stacey@afar.org
212-703-9977
American Federation for Aging Research
Source:Eurekalert

Related medicine news :

1. Sigma-Aldrich Offers Customizable Synthetic Extracellular Matrix for Stem Cell Research
2. Newly Published Research Indicates 97% of Apraxic Children Improving with Novel Nutritional Combination
3. Karmanos Chief Cancer Surveillance Researcher Discusses Study on Decreased Cancer Mortality Rates
4. Lifting weights reduces lymphedema symptoms following breast cancer surgery, Penn research shows
5. Researchers identify potential new avenue to attack cancer
6. Nicholas Vogelzang, MD, Joins US Oncology Research Network via Comprehensive Cancer Centers of Nevada
7. New Evidence-Based Research Shows that Universal Comprehensive Eye Exams Would Help More Children Succeed in School
8. Breakthrough in Alzheimers research
9. HerbalScience Research Identifies Specific Bioactives In Stabilized Rice Bran Extract that Impart Anti-Inflammatory Benefits
10. Stem Cell Advance May Further Disease Research
11. Researchers find alcoholics display abnormal brain activity when processing facial expressions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... ... 2017 , ... Maryland’s soybean farmers have improved the sustainability ... the United Soybean Board. , Thanks to the responsible use of technology ... on less land per bushel, the report says. The United Soybean Board’s “Soy ...
(Date:6/26/2017)... ... June 26, 2017 , ... New patients with missing ... Cotey, with or without a referral. Dr. Cotey is a trusted dentist who has ... tooth replacement option. , Patients with missing teeth in Fitchburg, WI, are encouraged to ...
(Date:6/25/2017)... ... ... CareSet Labs released the Root NPI Graph today at the 2017 Academy ... of the Doctor Referral teaming dataset commonly available from Medicare. , Originally created through ... “Doctor Referral Dataset” as released by Medicare and “DocGraph” as released by Trotter, the ...
(Date:6/24/2017)... ... June 24, 2017 , ... Dr. Mitchell Mehlman ... Road in Lake Ronkonkoma, Dental365 offers patients high-quality and affordable routine and emergency ... the dentist fit into their patients’ busy lifestyles. Dental365 also gladly work with ...
(Date:6/23/2017)... ... ... By scoring 100% for fiscal management and accountability, the Arthritis National Research ... Charity Navigator, validating ANRF's work as a top charity in America. , This achievement ... earns ANRF a spot on their “ 10 Charities Worth Watching ” list as ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... CHICAGO , June 19, 2017  Hill-Rom Holdings, Inc. ... conference call and webcast on Friday, July 28, 2017, beginning ... Conference Call Audio Only Dial-in information: To participate in the ... Please dial into the call at least 10 minutes prior ... Code is 34090339.  ...
(Date:6/16/2017)... -- Datascope Corp. is voluntarily performing a worldwide field correction of certain Intra-Aortic ... code.     ... NUMBER ... 0998-UC-0446HXX; 0998-UC-0479HXX 0998-00-3013-XX;  0998-UC-3013-XX ... This field correction also applies to any System ...
(Date:6/14/2017)... , June 14, 2017  ivWatch LLC, a medical ... of intravenous (IV) therapy, is pleased to announce it ... of Nonsurgical Hospital Supplies and Equipment at the 2017 ... for the medtech industry. The award was presented by ... K. Javits Center in New York ...
Breaking Medicine Technology: