Navigation Links
BIDMC investigator to receive vascular biology award from the American Heart Association
Date:3/22/2011

microvasculature walls in coronary artery disease [CAD] may not be just an undesirable by-product," he adds. "Instead, the increased ROS levels found in CAD may be a homeostatic response necessary to increase the synthesis of nitric oxide and thereby increase coronary dilation and blood supply to the heart."

In other words, ROS are also helpful.

Abid's laboratory arrived at this discovery after first studying human endothelial cells from coronary arteries.

"We reduced levels of ROS in these cell cultures, assuming that this would make the cells happy," he explains. "But we came up with totally opposite results. The coronary endothelial cells stopped growing and migrating."

Further investigations revealed that when ROS were reduced, the PI3K-Akt-eNOS pathways which are essential for cell growth and migration and the production of nitric oxide were also experiencing decreased activation. "We thought this might explain why the endothelial cells were so unhappy," says Abid.

To test this hypothesis, the investigators studied an NAPDH oxidase knockout mouse model containing a 50 percent reduction in ROS. (NAPDH oxidase is a major source of ROS in endothelial cells.) After isolating the intact coronary arterioles from the heart of the knockout mouse, as well as those from a wild-type control mouse, Abid's team exposed the coronary blood vessels from both groups of mice to vascular endothelial growth factor (VEGF), a protein known to promote blood vessel growth.

"Normal, healthy blood vessels will become dilated when they are exposed to VEGF," Abid explains. "Conversely, without ROS, the vessels of the knockout mice should have dilated even more when VEGF was introduced." But that wasn't what the scientists found.

"As we had hypothesized, by inhibiting ROS, we were also inhibiting the PI3K-Akt pathway as well as the production of nitric oxide by eNOS. We essentially came to the conclusion that if ROS is
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. BIDMC researcher receives Young Investigator Award from Prostate Cancer Foundation
2. Scott & White Healthcare pathologist is co-investigator on breast cancer study
3. SEBM Young Investigator Awards for 2010
4. BUSM researcher receives prestigious young investigator award
5. Investigators examine colorectal cancer screening methods among diverse populations
6. University of Utah afib specialist, Marcos Daccarett, M.D., wins Young Investigator Award
7. UT Southwestern investigators perform head-to-head comparison of incontinence treatments
8. Damon Runyon Cancer Research Foundation awards $3.1M to 8 top young clinical investigators
9. Investigators identify gene associated with kidney disease in African-American population
10. SWOG names 5 cancer researchers outstanding Young Investigators
11. NCH investigators receive grant to distinguish bacterial infections from viral infections in infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Innovations announces the upcoming airing of ... Monday, October 20, 2014 at 7:30 a.m. EST/PT via ... behind the scenes to learn about Break the Cycle’s ... the practical help and information Break the Cycle provides ... signs of abuse, how to navigate the legal system, ...
(Date:10/1/2014)... Inc., announced today their new NoteSwift™ 2.0 for Allscripts ... the bridge between the EHR and Dragon Medical interpreting ... at the point of care. NoteSwift reduces the time ... than half – and virtually eliminates mouse clicks – ... EHR use according to the June 12, 2014 HIMSS ...
(Date:10/1/2014)... Scientists at the University of Western Australia ... system proteins has the power to knock out mesothelioma ... the new study on their website. Click here ... the UWA School of Pathology and Laboratory Medicine administered ... mesothelioma with promising results. , “A timed triple ...
(Date:10/1/2014)... Ethiopia, at the occasion of the Leishmaniasis East ... African and international leishmaniasis experts, results of a ... monitoring plan, carried out by MSF, DNDi, ... Ethiopia, were presented to key decision makers in ... kala-azar with the combination of Sodium Stibogluconate and ...
(Date:10/1/2014)... October is national Breast Cancer Awareness Month—an ... while raising money for breast cancer research. Pelican Water ... in the effort to find a cure. ... of having access to clean, healthy water. Research has ... certain forms of cancer. , The Problem of ...
Breaking Medicine News(10 mins):Health News:Innovations to Explore Breakthroughs in Health and Wellness in Upcoming Episode Airing Monday, October 20, 2014 via Discovery Channel 2Health News:NoteSwift Joins Allscripts Developer Program 2Health News:NoteSwift Joins Allscripts Developer Program 3Health News:New Mesothelioma Study Says Mice Cured by Immuntherapy “Cocktail”, Reports Surviving Mesothelioma 2Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2Health News:Pelican Water Supports Breast Cancer Awareness Month with Order Donations 2
... the first ever country-by-country analysis of the impact ... revealed that 13 million deaths worldwide could ... ,The report shows huge inequalities but ... could be improved by reducing environmental risks, including ...
... star Lily Allen has blamed her alcohol addiction to the nervousness ... of doing a bad show makes her drink even more. ... about doing bad shows," the Daily Mail quoted Allen, as telling ... to get back into the studio. I've actually pulled myself aside ...
... to the researchers in new University of Cincinnati ... or underlying vascular malformations. ,In a ... arterial aneurysms, Todd Abruzzo, MD, found that the most ... to occur spontaneouslywith no related trauma or infection, recognizable ...
... humour may help their babies fight skin allergies, according ... of New Scientist. ,Japanese researcher Hajime Kimata at ... baby with a common allergy, mild atopic eczema. Some ... movie or boring footage about weather, and their breast ...
... patients with heart disease. ,Earlier, a study ... percent, at all doses (81 mg, 162 mg and 325 ... to prevent and treat coronary artery disease. Most coronary artery ... blood clots (thrombosis) that block blood flow within arteries, resulting ...
... into the workings of the human genome has led scientists ... for life is badly flawed. The ground-breaking study, published ... sides of the Atlantic, takes a small percentage of the ... the biological role of every component. ,For the ...
Cached Medicine News:Health News:13 Million Die Worldwide Due to Unhealthy Environment: New WHO Report 2Health News:Different Causes for Childhood Brain Aneurysm was Revealed 2Health News:Landmark Study Prompts Rethink of Genetic Code 2Health News:Landmark Study Prompts Rethink of Genetic Code 3
(Date:9/30/2014)... Sept. 30, 2014 /CNW/ - Protecting the health and safety of ... Canada uses the appropriate powers and tools at its disposal to ... and quality standards. To that end, Health ... the import into Canada of all drug ... They are: , Apotex Pharmachem India Pvt Ltd ...
(Date:9/30/2014)... , Sept. 30, 2014  Hologic, Inc. (NASDAQ: ... , Hologic,s President and Chief Executive Officer, will preside ... October 1, the first day of Breast Cancer Awareness ... Company,s campaign focused on the important benefits of Hologic,s ... the FDA as clinically superior to traditional mammography. ...
(Date:9/30/2014)... -- This study provides an analysis of the ... nuclear imaging informatics, PET imaging informatics, and multimodality ... size of the market based on its historic ... growth based on the current drivers and restraints, ... the broader markets for imaging equipment, advanced visualization, ...
Breaking Medicine Technology:Statement by the Honourable Rona Ambrose on the import ban of drug products from three plants in India 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 3Analysis of the US Molecular Imaging Informatics Market 2Analysis of the US Molecular Imaging Informatics Market 3
Specially designed wider jaws to help split soft nucleus, cross action, round handle, maximum opening 2.8 mm....
Cross action, round handle, maximum opening 2.8 mm....
Irrigating nucleus chopper, wedge-shaped inferior edge with, blunt tip, 0.6 mm dual sideports, 20 gauge....
Nucleus chopper. For bimanual nucleus division....
Medicine Products: