Navigation Links
B cell receptor inhibitor causes chronic lymphocytic leukemia remission
Date:12/11/2011

SAN DIEGO - A new, targeted approach to treating chronic lymphocytic leukemia has produced durable remissions in a Phase I/II clinical trial for patients with relapsed or resistant disease, investigators report at the 53rd Annual Meeting of the American Society of Hematology.

"PCI-32765, one of a new class of experimental drugs called B cell receptor inhibitors, has shown impressive potential in this clinical trial for its effectiveness and particularly for its relatively minimal toxicity," said lead investigator Susan O'Brien, M.D., professor in the Department of Leukemia at The University of Texas MD Anderson Cancer Center.

According to the National Cancer Institute's Surveillance Epidemiology and End Results database, an estimated 14,570 people will receive a diagnosis of CLL in 2011 and about 4,380 patients will die of the disease.

Six-month progression free survival of 90-92 percent

Of 27 CLL patients treated at a dose of 420 milligrams daily, 70 percent had complete or partial remission at 10.2 months of median follow-up. Six-month progression-free survival was 92 percent. Patients received a median three prior treatments before entering the clinical trial.

At a higher dose of 840 mg, 44 percent of 34 patients achieved complete or partial remission at 6.5 months median follow-up, similar to the response rate of the lower-dose cohort at 6.2 months. Progression free survival at 6 months was 90 percent. Study participants had received a median of five prior treatments.

Overall, five patients (8 percent) of the 61 from both arms had progressive disease and 50 (82 percent) remained on the therapy.

Drug does not suppress blood cell production

CLL presently is treated with combination chemotherapies that can cause myelosuppression - inhibited bone marrow function leading to decreased production of blood cells. The resulting susceptibility to infection can be a problem for patien
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Toll-like receptors play role in brain damage in newborns
2. Folate receptors may serve as a front door to ovarian cancer treatment
3. Nuclear receptors battle it out during metamorphosis in new fruit fly model
4. Cell receptor could allow measles virus to target tumors
5. CSHL structural biologists reveal novel drug binding site in NMDA receptor subunit
6. Historic first images of rod photoreceptors in the living human eye
7. Older age memory loss tied to stress hormone receptor in brain
8. Entire T-cell receptor repertoire sequenced revealing extensive and unshared diversity
9. Researchers get a grip on nervous systems receptors
10. Feast or famine: Researchers identify leptin receptors sidekick as a target for appetite regulation
11. Targeting nicotine receptors to treat cognitive impairments in schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... 19, 2013 The benefits, NASS ... sauna but the overall experience for the majority of ... health-wise. , Mr Mouw, whose Virgina-based company enjoys an ... statement by saying that the type of sauna is ... number of counterfeit imitations which frankly, can be extremely ...
(Date:6/19/2013)... 2013 Across the globe billions of ... access to the medical advances that benefit developed western ... health care and the necessary aid to help curb ... , Outlook with Ben Kingsley is partnering ... in which these people live and highlight the invaluable ...
(Date:6/19/2013)... Denver, Colorado (PRWEB) June 19, 2013 Daily ... vertical jump training method will be published on ... a preview of the article to inform readers about the ... the declaration made by reporters working at Daily Gossip, the ... Manual Guide . , Hiller has understood during the ...
(Date:6/19/2013)... Are you using Twitter in your marketing campaigns? ... , Social media marketing is a proven and affordable ... Included in your social media campaigns should be Twitter messaging, ... and revenue for your business. , According to Statistic ... Many of these individuals are not just using the service ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 Researchers from ... demonstrated several new studies at ENDO 2013, ... from June 15-18 in San Francisco.     , Mount Sinai ... as the role of prostastic acid phosphatase (PAP) in ... can stimulate the thyroid gland; revealed the prevalence of ...
Breaking Medicine News(10 mins):Health News:Health Benefits of Saunas Only Viable with Properly Constructed Models, Warns Manufacturer 2Health News:The Jump Manual Review: Reveals Hiller’s Method of Vertical Jump Training 2Health News:If Your Massage Practice Isn’t Tweeting, It Isn’t Generating New Sales: 3 Ways Twitter Helps Grow Massage Practices from Appointment-Plus 2Health News:Diabetes Patients That Bring Glucose Meters to Doctor Visits Have Better Control Over Their Disease 2Health News:Diabetes Patients That Bring Glucose Meters to Doctor Visits Have Better Control Over Their Disease 3Health News:Diabetes Patients That Bring Glucose Meters to Doctor Visits Have Better Control Over Their Disease 4Health News:Diabetes Patients That Bring Glucose Meters to Doctor Visits Have Better Control Over Their Disease 5Health News:Diabetes Patients That Bring Glucose Meters to Doctor Visits Have Better Control Over Their Disease 6Health News:Diabetes Patients That Bring Glucose Meters to Doctor Visits Have Better Control Over Their Disease 7
... more stress can lead to the growth and spread of ... remarkable finding suggests that stress results in the release of ... released during stress stimulates cancer cells to produce two compounds ... the cells to move easily into the bloodstream and travel ...
... to treat seizures and migraine headaches, can increase the ... Southwestern Medical Center have found. ,A study – ... of topiramate affects kidney-stone formation – appears in the ... ,Several case reports have described an association ...
... from major depression can become symptom-free if they are ... treatments to determine which work best for them, which ... to the mix. ,The largest study on treatments ... that 67 percent of patients achieved a full remission ...
... bird flu virus has been detected in Asia, the British ... for any evidence of bird flu. ,The death ... and parks will be brought to the notice of the ... 1,200 sq Kms area will be brought under surveillance. ...
... world-wide survey which has sought to understand sexual behaviors ... pre-marital sex //in the present day are baseless and ... of this survey are published in The Lancet. ... which showed that many had just a single recent ...
... been grown from umbilical cord blood stem cells for the ... animal experiments for drug testing. ,According to the ... is just the initial phase of generating segments that can ... a mature functioning form. ,Scientists from Newcastle ...
Cached Medicine News:Health News:More Stress, More Cancer 2Health News:More Stress, More Cancer 3Health News:Drug Prescribed for Migraines and Seizures Increases Risk of Kidney Stones 2Health News:Drug Prescribed for Migraines and Seizures Increases Risk of Kidney Stones 3Health News:Carefully Monitored Treatment Can Help Those Who Suffer from Depression 2Health News:Carefully Monitored Treatment Can Help Those Who Suffer from Depression 3Health News:Artificial Liver from Cord Blood Stem cells 2
(Date:6/19/2013)... 19, 2013 Pharmacyclics, Inc. (the "Company") (Nasdaq: ... New England Journal of Medicine ( NEJM ) ... the investigational oral Bruton,s tyrosine kinase (BTK) inhibitor ibrutinib ... small lymphocytic lymphoma (SLL). Ibrutinib was shown to be ... SLL, even in patients who were at high-risk due ...
(Date:6/19/2013)... , June 19, 2013   NextDocs announced ... service clinical research organization, at DIA 2013 , ... companies will present case studies that explore best practices ... to electronic trial master file (eTMF) systems. ... will present alongside Krystyna Kowalczyk , executive vice ...
(Date:6/19/2013)... -- The Physician-Patient Alliance for Health & Safety recently released ... to urgently address this issue has been emphasized by ... "Medical device alarm safety in hospitals." According to The Joint ... 2012, there were 98 alarm related events reported, of which: ... 13 resulted in permanent loss of function (13%) , ...
Breaking Medicine Technology:Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 2Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 3Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 4Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 5Ibrutinib Study Results in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia Published in The New England Journal of Medicine 6NextDocs and Novella to Present on eTMF at DIA 2013 2Three Lessons Learned to Reduce Alarm Fatigue and Improve Alarm Management and Patient Safety in Hospitals 2Three Lessons Learned to Reduce Alarm Fatigue and Improve Alarm Management and Patient Safety in Hospitals 3
The Lineage acetabular system with ceramic liners uses sophisticated manufacturing methods and materials to minimize wear debris generation....
Hemisphere modular Cup....
Cer-Met series II system....
Derived from an extensive study into increasing the range of motion in hip replacement, the cemented SHP acetabular cup is a unique design and is manufactured from ArCom polyethylene....
Medicine Products: