Navigation Links
B Cells Can Act Alone in Autoimmune Diseases
Date:8/7/2008

Finding points to new interventions to control body's attack on its own healthy tissue

THURSDAY, Aug. 7 (HealthDay News) -- B cells may be more responsible for causing autoimmune diseases like lupus or rheumatoid arthritis than initially thought, according to a new study.

The finding, published in the Aug. 7 online issue of the journal Immunity, may give scientists a new path to pursue in finding ways to stop the immune system's chronic attacks on the body's own tissue during these diseases.

B cells, the source of damaging auto-antibodies, have long been thought to remain quiet in autoimmune diseases unless they are given a kick-start by T-cells. Researchers from Yale and Boston universities had found that toll-like receptors recognize and react to "self" molecules, in particular mammalian DNA and RNA. When this occurs, these receptors help activate B cells that make the classical auto-antibodies of lupus.

These signals, like those from T-cells, start the autoimmune process in B cells. In the new study, the researchers theorize that once activated in this way, the B cells can subsequently recruit T-cells. This creates a "vicious cycle" of chronic autoimmune disease in which the two types of cell prod each other into action.

The findings could explain why autoimmune-disease treatments aimed at T-cells have not done as well as those targeting B cells, the researchers said.

More information

The U.S. National Library of Medicine has more about autoimmune diseases.



-- Kevin McKeever



SOURCE: Yale University, news release, Aug. 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
2. Brain cells work differently than previously thought
3. Embryonic Stem Cells Repair Human Heart
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Circulating fats kill transplanted pancreas cells, study shows
6. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
7. Melanoma drug revs immune cells but cancer cells ignore it
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Embryonic stem cells used to grow cartilage
10. Molecular probe paints cancer cells in living animals, Stanford researchers find
11. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... , ... A new partnership between Goodwill® and Roadie, Inc. aims to make ... clothes to couches to dressers and bicycles. Roadie — the national on-the-way delivery network ... donation center through February 28th. , “January is an exciting time when resolutions ...
(Date:1/20/2017)... ... January 20, 2017 , ... Bionic Sports Nutrition LLC, an American company devoted ... had a successful January ECRM Trade Show in Hilton Head, SC. , Bionic ... it to provide its products to all clients at reasonable prices. At the ECRM ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... Michael and ... Dana Farber Cancer Institute. For Betsy, the clinical trial has been life-saving as ... has not worsened. , Betsy Brauser was diagnosed with ovarian cancer in 2009. ...
(Date:1/20/2017)... ... ... “The Angel”: a heartwarming and earnest tale of faith and believing in ... Angel” is the creation of published author, Marjorie Lund-Fontaine, a former professional violinist, alumnus ... When asked of her new book, Marjorie says, “‘The Angel’ was written as a ...
(Date:1/20/2017)... ... , ... “Christmas in Suffolk”: a story of love, secrets, and mystery. ... Lafayette, Indiana where she works in a daycare and looks for inspiration in the ... Christian Faith Publishing, Sara Seymour’s new book is an adventure of love and secrets. ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Jan. 19, 2017 Many patients don,t realize ... medication when a pharmacy just a few blocks away ... alleviate this problem Medicationdiscountcard.com has created a ... exactly how much their medication will cost at most ... Medicationdiscountcard.com takes all ...
(Date:1/19/2017)... Accuray Incorporated (Nasdaq: ARAY ) ... to set the bar for excellence in customer satisfaction. ... satisfaction rating among radiation treatment delivery systems in the ... Intelligence Briefing™. The most recent ratings trend also shows ... peers for 11 of the past 12 quarters. ...
(Date:1/19/2017)... CLEVELAND , Jan. 19, 2017 ViewRay, ... (DFG), a federal institution supporting research in ... installation and patient treatments at the University Clinic Heidelberg ... The MRIdian Linac program will be headed ... who also heads radiation oncology at the German Cancer ...
Breaking Medicine Technology: