Navigation Links
Award-winning study says back pain may be in your genes
Date:4/8/2008

What do you learn by looking at the spines of hundreds of Finnish twins? If you are the international team of researchers behind the Twin Spine Study, you find compelling proof that back pain problems may be more a matter of genetics than physical strain.

The findings of the Twin Spine Study, an ongoing research program started in 1991, have led to a dramatic paradigm shift in the way disc degeneration is understood. Last month a paper presenting an overview of the Twin Spine Studys multidisciplinary investigation into the root causes of disc degeneration received a Kappa Delta Award from the American Academy of Orthopaedic Surgeons, arguably the most prestigious annual award in musculoskeletal research.

In the past, the factors most commonly suspected of accelerating degenerative changes in the discs were various occupational physical loading conditions, such as handling of heavy materials, postural loading and vehicular vibration, said lead researcher Michele Crites-Batti of the University of Albertas Faculty of Rehabilitation Medicine.

Drawing on information from 600 participants in the population-based Finnish Twin Cohort147 pairs of identical and 153 pairs of fraternal male twinsthe Twin Spine Study has turned the dominant injury model approach to disc degeneration on its head. Researchers from Canada, Finland, the United States and the United Kingdom compared identical twin siblings who differed greatly in their exposure to a suspected risk factor for back problems; for example, one of the twins had a sedentary job while the other had heavy occupational physical demands, or one routinely engaged in occupational driving while the other did not. The studies yielded startling results, suggesting that genetics play a much larger role in disc degeneration than previously thought.

Despite extraordinary differences between identical twin siblings in occupational and leisure-time physical loading conditions throughout adulthood, surprisingly little effect on disc degeneration was observed. The findings indicated that while physical loadinghandling heavy loads, bending, twisting and static work in awkward posturesappears to influence disc degeneration, the effects are very modest. During the course of the exposure-discordant twin studies, said Crites-Batti, the observation that struck anyone who viewed the twin sibling images side-by-side was the strong resemblance in disc degeneration, not only in the degree of degeneration, but also in the types of findings and spinal levels involved.

The Twin Spine Study is far from over: having found evidence that genetics may play an overlooked role in disc degeneration, the team of North American and European is now working to identify the specific genes and biological mechanisms influencing disc degeneration and back pain problems; understanding how degeneration progresses over time; and differentiating normal, inconsequential changes from degenerative changes that lead to pain.

This advance in the understanding of disc degeneration provides a foundation from which to develop new hypotheses and more fruitful research that may help shed light on one of the most common and costly musculoskeletal conditions facing the developed countries of the world, said Crites-Batti.


'/>"/>

Contact: Isabela C. Varela
isabela.varela@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Related medicine news :

1. Sharing Miracles Television Program to Feature Emmy Award-Winning Actor Joey Pantoliano
2. Asthma Foundation Appoints Award-Winning Scholar to Top Policy Position
3. Dr. Oliver Sacks, NYT Bestselling Author, to Inspire and Marc Black, Award-winning Musician, to Perform at National Aphasia Association Benefit on April 1, NYC
4. Blind Tibetan Teenagers Featured in Award-Winning Film, Blindsight, Unite with Students from Junior Blind of America to Share Life Experiences
5. Companys Award-Winning Sound Enhancement Technology Proven to Provide Superior Performance Over Other Technologies; Patent Will Enhance Able Planet, LINX AUDIO Brands
6. BET Rolls Out a Weekend of Award-Winning, HIV-Themed Programming Commemorating World AIDS Day
7. Thinnovation at RSNA 2007: Visage Imaging to Showcase Award-Winning Thin Client PACS Solutions
8. BET Networks Award-Winning Rap-It-Up HIV/AIDS Campaign Returns to New York City for The Youth Empowerment Tour on November 13-16
9. New St. Lukes Medical Clinic Selects Award-Winning globalcentara Provider(SM) by Houstons Global Healthcare Alliance
10. Video: Grin Big With an Award-Winning Smile
11. MetLife Foundation Begins New Phase of Award-Winning Parenting Skills Campaign in Collaboration with the Partnership for a Drug-Free America(R)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Rock, AR (PRWEB) , ... October 13, 2017 ... ... firm with locations throughout Arkansas that offers insurance and financial preparation services, is ... benefit the Rock City Rescue organization. , Rock City Rescue is a locally ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The American Board ... become its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon ... beginning July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical ... the primary prevention of cardiovascular diseases during the 15th Annual Women’s Health ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... The Rebound mobile app is poised to become ... tide of prescription drug addiction. The app empowers users to ... stepping down their dosage in a safe, controlled manner while ... the first 100,000 people to sign up will enjoy 3 ... ...
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans ... advance the use of wearable and home sensors for ... disorders. Early Signal Foundation, a nonprofit organization focused on ... will provide an affordable analytical system to record and ... ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), ... solutions, today announced that its MyDario product is expected to appear on ... for when The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. ... ...
Breaking Medicine Technology: