Navigation Links
Avoiding specific region of brain during whole-brain radiotherapy prevents memory loss
Date:9/23/2013

Atlanta, September 23, 2013Limiting the amount of radiation absorbed in the hippocampal portion of the brain during whole-brain radiotherapy (WBRT) for brain metastases preserves memory function in patients for up to six months after treatment, according to research presented today at the American Society for Radiation Oncology's (ASTRO's) 55th Annual Meeting.

The single-arm, phase II study was a multi-institutional, international clinical trial in the U.S. and Canada, conducted through the Radiation Therapy Oncology Group (RTOG). Researchers compared the study group to a historical control group of patients who had received WBRT without hippocampal avoidance in the PCI-P-120-9801 phase III trial (Li 2007).

This study enrolled 113 adult patients from 2011 through 2013 who had a measurable brain metastasis outside a 5-mm margin around the hippocampus. Of those patients, 100 were analyzable and 76 percent were categorized as recursive partitioning analysis (RPA) class II. All patients received hippocampal avoidance whole-brain radiotherapy (HA-WBRT) to 30 Gy in 10 fractions. In all analyzable patients, the dose received by the entirety of the hippocampus did not exceed 10 Gy, and the maximum dose did not exceed 17 Gy. Patients were assessed using the Hopkins Verbal Learning Test - Delayed Recall (HVLT-DR), the HVLT - Recall (HVLT-R) and the HVLT - Immediate Recognition (HVLT-IR) at baseline and post-treatment at two-, four- and six-month intervals. The primary endpoint of the trial was the HVLT-DR at four months.

Results showed that the 42 patients who were analyzable at four months post-RT had a seven percent decline in HVLT-DR from baseline to four months (95 percent confidence interval (CI): -4.7 percent to 18.7 percent). This is statistically significant when compared to the historical control group (p=0.0003), which demonstrated a 30 percent decline in HVLT-DR at four months. Six months after treatment, the 29 analyzable patients had a two percent decline in HVLT-DR from baseline (95 percent CI: -9.2 percent to 13.1 percent).

"Radiotherapy to the brain is known to impact the memory function of cancer survivors," said Vinai Gondi, MD, lead author of the study, Co-Director of the Cadence Brain Tumor Center and Associate Director of Research at the Cadence Proton Center in Warrenville, Ill, and Clinical Assistant Professor at the University of Wisconsin School of Medicine and Public Health in Madison, Wis. "A compartment of neural stem cells located in the hippocampus, sensitive to radiotherapy and important for memory function, is thought to be central to these effects. Our research group developed advanced radiotherapy techniques that spare this hippocampal neural stem cell compartment from significant radiation doses. The study results were statistically better than historical data of whole-brain radiotherapy without hippocampal sparing and present a number of opportunities to introduce hippocampal sparing in other contexts of radiotherapy to the brain. The RTOG is currently developing phase III trials to explore these other contexts and to validate these results."


'/>"/>

Contact: Michelle Kirkwood
michellek@astro.org
703-286-1600
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. Download Merrill DataSites Report - Avoiding the Common Pitfalls in M&A Transactions
2. New Survey of Aging Experts Gives Top 5 Tips for Avoiding Family Feud when Caring for Aging Parents
3. 10 Tips to Avoiding Injuries During Exercise from Medicine in Motion
4. Avoiding Scary Situations May Leave Kids More Anxious: Study
5. Avoiding Hospital Readmissions Boot Camp and Survive and Thrive in the Changing Health Care Environment - ABQAURP's 36th Annual Health Care Quality Conference
6. Michigan Criminal Attorney, Loren Dickstein, Successfully Assists Client with Avoiding Serving Time in Federal Prison
7. 101 Medical Weight Loss’s Top Tips for Avoiding Weight Gain this Holiday Season
8. Avoiding Alcohol May Cut Risk for Esophageal Cancer
9. Potential treatment for a specific kind of pancreatic cancer
10. LDM and gMed Partner to Bring Clinically Relevant Healthcare Messages to Patients and Specialty Specific EHR Providers
11. Researchers develop specific tests to identify cancer biomarkers in dermatomyositis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... Registration is now open for the 31st annual AIDS ... the Hatch Memorial Shell on the Esplanade. The event regularly draws thousands of participants, making ... a competitive, timed event fully sanctioned by the USA Track & Field Association. , ...
(Date:5/3/2016)... ... ... Elizabeth Murray has always loved walking one to two miles a day. ... and one on her arm. But she got to the point where she could ... , The valves of the heart wouldn’t close properly resulting in mitral regurgitation, where ...
(Date:5/3/2016)... ... May 03, 2016 , ... Empyrean ... launching a new client service center in La Vergne, Tennessee, near Nashville. The ... the full range of Empyrean client services. , “Our Nashville-area center allows us ...
(Date:5/3/2016)... ... May 03, 2016 , ... Ogawa World USA introduced ... user friendly Samsung tablet and exclusive Smart Application. The Smart 3D combines the best ... massage with a customized user profile and specialized massage program, each user has a ...
(Date:5/3/2016)... ... May 03, 2016 , ... Dr. Poneh Ghasri, ... dental treatments to both new and existing patients. Cosmetic dentistry allows patients to improve ... who have healthy smiles with some minor or more serious cosmetic flaws. These specials ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016  Marking its ... accessible breast and ovarian cancer risk test, ... analyzing 30 genes that highly impact the most ... Available today, the Color Test analyzes hereditary cancer ... stomach, and uterine cancers. The Color Test is ...
(Date:4/28/2016)... YORK , April 28, 2016 ... online consumer insights on healthcare, announced today that it ... their report Cool Vendor in Life Sciences, 2016, ... April 15, 2016.  The report focuses on life-science- oriented ... gain insight from patients and doctors, confirm medication ingestion, ...
(Date:4/28/2016)... , April 28, 2016 Oramed ... a clinical-stage pharmaceutical company focused on the development of oral ... in the upcoming PIONEERS 2016 conference, presented by Joseph ... 2016 in New York . Nadav ... at the conference. Presentation Details:   ...
Breaking Medicine Technology: