Navigation Links
Avoiding specific region of brain during whole-brain radiotherapy prevents memory loss
Date:9/23/2013

Atlanta, September 23, 2013Limiting the amount of radiation absorbed in the hippocampal portion of the brain during whole-brain radiotherapy (WBRT) for brain metastases preserves memory function in patients for up to six months after treatment, according to research presented today at the American Society for Radiation Oncology's (ASTRO's) 55th Annual Meeting.

The single-arm, phase II study was a multi-institutional, international clinical trial in the U.S. and Canada, conducted through the Radiation Therapy Oncology Group (RTOG). Researchers compared the study group to a historical control group of patients who had received WBRT without hippocampal avoidance in the PCI-P-120-9801 phase III trial (Li 2007).

This study enrolled 113 adult patients from 2011 through 2013 who had a measurable brain metastasis outside a 5-mm margin around the hippocampus. Of those patients, 100 were analyzable and 76 percent were categorized as recursive partitioning analysis (RPA) class II. All patients received hippocampal avoidance whole-brain radiotherapy (HA-WBRT) to 30 Gy in 10 fractions. In all analyzable patients, the dose received by the entirety of the hippocampus did not exceed 10 Gy, and the maximum dose did not exceed 17 Gy. Patients were assessed using the Hopkins Verbal Learning Test - Delayed Recall (HVLT-DR), the HVLT - Recall (HVLT-R) and the HVLT - Immediate Recognition (HVLT-IR) at baseline and post-treatment at two-, four- and six-month intervals. The primary endpoint of the trial was the HVLT-DR at four months.

Results showed that the 42 patients who were analyzable at four months post-RT had a seven percent decline in HVLT-DR from baseline to four months (95 percent confidence interval (CI): -4.7 percent to 18.7 percent). This is statistically significant when compared to the historical control group (p=0.0003), which demonstrated a 30 percent decline in HVLT-DR at four months. Six months after treatment, the 29 analyzable patient
'/>"/>

Contact: Michelle Kirkwood
michellek@astro.org
703-286-1600
American Society for Radiation Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Download Merrill DataSites Report - Avoiding the Common Pitfalls in M&A Transactions
2. New Survey of Aging Experts Gives Top 5 Tips for Avoiding Family Feud when Caring for Aging Parents
3. 10 Tips to Avoiding Injuries During Exercise from Medicine in Motion
4. Avoiding Scary Situations May Leave Kids More Anxious: Study
5. Avoiding Hospital Readmissions Boot Camp and Survive and Thrive in the Changing Health Care Environment - ABQAURP's 36th Annual Health Care Quality Conference
6. Michigan Criminal Attorney, Loren Dickstein, Successfully Assists Client with Avoiding Serving Time in Federal Prison
7. 101 Medical Weight Loss’s Top Tips for Avoiding Weight Gain this Holiday Season
8. Avoiding Alcohol May Cut Risk for Esophageal Cancer
9. Potential treatment for a specific kind of pancreatic cancer
10. LDM and gMed Partner to Bring Clinically Relevant Healthcare Messages to Patients and Specialty Specific EHR Providers
11. Researchers develop specific tests to identify cancer biomarkers in dermatomyositis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... New York (PRWEB) October 25, 2014 ... mesh lawsuits ( http://www.vaginalmeshlawsuit2015.com/ ) filed against ... underway in U.S. District Court, Southern District of ... Summary Judgment on Punitive Damages in a group ... In a ruling issued on October 21st, U.S. ...
(Date:10/25/2014)... Oct. 24, 2014 (HealthDay News) -- Interrupting blood supply to ... reduce the risks associated with the surgery, according to a ... stop the blood supply to the heart to be able ... the heart will reduce its ability to produce energy because ... flow to another large muscle, such as an arm or ...
(Date:10/25/2014)... (HealthDay News) -- Researchers who discovered antibiotics in ... cause for concern. The use of antibiotics ... human consumption contribute to the development of antibiotic-resistant ... information from the study. Each year in ... million people and kill about 23,000, according to ...
(Date:10/25/2014)... By Randy Dotinga ... -- As more genetic tests are developed that spot increased ... would be more proactive about getting screened. But a ... does not change behavior: People who found out their genes ... than people with average risk to get screened. "It ...
(Date:10/22/2014)... On Saturday, October 25, 2014, the Brownsville Community Health Center ... fair ¡Vive tu vida! Get Up! Get Moving!®. The event ... health and wellness for people of all ages and all ... public, will be held at Dean Porter Park, 501 E. ... , “¡Vive tu Vida! Get Up! Get Moving!® helps ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 4Health News:Brief Interruption of Blood Supply to Limb Might Aid Heart Surgery: Study 2Health News:Researchers Say Antibiotics in Fish a Health Concern 2Health News:Knowing Genetic Risk for Cancer May Not Change Behavior 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 4
... ... ... -- At a private reception held last Thursday evening, the Minneapolis-St. Paul Business Journal unveiled ... Marketing , a full-service marketing firm based in St. Paul, earned the No. 35 spot ...
... Safe Tables Our Priority survey demonstrates need for better ... Oct. 30 A survey of state health departments ... that the response and investigation of outbreaks varies greatly ... The survey was commissioned by the Produce Safety Project ...
... around right after procedure cuts conception rate, study found ... lie flat for 15 minutes after being artificially inseminated ... suggests. , "Allowing women treated for subfertility with IUI ... a 50 percent higher chance at conceiving," said Inge ...
... for those thrown off schedule by Daylight Saving Time ... of sleep you,ll get in most parts of the country ... Daylight Saving Time could spell trouble for your body clock, ... director of the sleep disorders research program in the division ...
... (NYSE: AGP ) today announced that net income for the ... share, versus $37.9 million, or $0.71 per diluted share, for the ... with the preliminary earnings range that the Company issued on ... associated with the onset of what appears to be a severe ...
... 30 First Choice Health Services, Inc. today announced that ... a compilation of the top-performing home health agencies in the ... of agencies and further highlights the top 100 and top ... performance measures in quality outcomes, quality improvement, and financial performance. ...
Cached Medicine News:Health News:Imagewrks Marketing Named Among Top 50 Fastest Growing Private Companies in Minnesota 2Health News:Survey of State Health Departments Underscores Gaps in Foodborne Illness Response 2Health News:Survey of State Health Departments Underscores Gaps in Foodborne Illness Response 3Health News:Lying Still Raises Artificial Insemination Success 2Health News:Lying Still Raises Artificial Insemination Success 3Health News:When Clocks Change, Body May Need Time to Adjust 2Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 2Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 3Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 4Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 5Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 6Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 7Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 8Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 9Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 10Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 11Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 12Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 13Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 14Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 15Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 16Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 17Health News:AMERIGROUP Reports Q3 Net Income of $22.5 Million or $0.43 per Diluted Share 18Health News:First Choice Health Services, Inc. Named to 2009 HomeCare Elite as a Top Home Health Care Provider 2Health News:First Choice Health Services, Inc. Named to 2009 HomeCare Elite as a Top Home Health Care Provider 3
(Date:10/22/2014)... Oct. 22, 2014   Surefire Medical , Inc., ... designed to maximize targeted delivery of embolization agents in ... that oncologist John R. Daniels , MD of ... and surgical oncologist Steven C. Katz , MD ... Company,s Scientific Advisory Board (SAB).    "The ...
(Date:10/22/2014)... -- Sanomedics International Holdings, Inc. (OTCQB: SIMH) – According ... Data Services, demand for thermometers is expected to grow ... demand for more accurate digital thermometers continues.  ... market for thermometers, and one of the companies serving ... Inc. Sanomedics International Holdings designs, develops, markets, ...
(Date:10/22/2014)... AUSTIN, Texas , Oct. 22, 2014 ... announced they have entered into a license and ... to target cancers. PhosImmune possesses technology ... the surfaces of tumor cells in association with ... from proteins that play a role in malignancy, ...
Breaking Medicine Technology:Surefire Medical's Scientific Advisory Board Expands, Broadens Clinical Trial Expertise 2Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2Biotech Companies To Co-Discover And Co-Develop Antibodies Targeting Novel Phosphopeptide Tumor Targets 2
The Optronics MicroFire is an easy to use versatile 2-Megapixel color microscope camera with Firewire connectivity. The camera mounts easily on your microscope with a C-mount adapter and is the perfe...
Rubella IgM ELISA....
H. pylori IgG ELISA....
Mumps IgG ELISA....
Medicine Products: