Navigation Links
Avastin No Benefit to Older Lung Cancer Patients: Study
Date:4/17/2012

By Steven Reinberg
HealthDay Reporter

TUESDAY, April 17 (HealthDay News) -- Medicare patients who have advanced non-small cell lung cancer appear to get no survival benefit from adding the drug Avastin to standard chemotherapy, researchers from the Dana-Farber Cancer Institute report.

An earlier trial had found that Avastin (bevacizumab) did improve survival, but not in patients aged 65 and older. Even so, the researchers noted, most patients diagnosed with non-small cell lung cancer are 65 and older and Medicare still covers the cost of the drug.

"A drug that we were just ecstatic about in 2006, we have to be more circumspect about," said lead researcher Dr. Deborah Schrag, an oncologist at Dana Farber, in Boston.

Avastin should be used judiciously, she added, noting that "older patients should discuss it with their doctors, but we cannot say it provides a survival advantage based on these data."

However, Schrag does not think Medicare needs to reconsider funding Avastin. "It may be that it helps some patients," she said. "But we should not assume that Avastin needs to be part of the treatment package."

Genentech, the maker of Avastin, said in a statement Tuesday that while the study "is well-conducted, retrospective analyses that use administrative information to determine clinical outcomes have limitations."

"Genentech agrees that certain people, such as those older than 65, are typically underrepresented in randomized, controlled clinical trials used for regulatory submissions. To address this, we collect and present data on the 'real world' use of medicines through large phase 4 prospective observational studies, which even when well-designed, also have limitations, including non-randomization of study participants."

The cost of the medication is also a factor in considering the use of Avastin, experts have said.

In 2011, published reports pegged the cost of the drug at somewhere between $4,000 and $9,000 a month, depending on co-pay assistance that's available from Genentech, Avastin's manufacturer.

This latest report was published in the April 18 issue of the Journal of the American Medical Association. The U.S. National Cancer Institute funded the study.

For the study, Schrag's team randomly assigned more than 4,000 Medicare patients with advanced non-small cell lung cancer to one of two groups.

One group received Avastin plus chemotherapy, while the other group was treated with chemotherapy alone. The researchers compared survival between the groups.

They found average survival for patients receiving Avastin plus chemotherapy was 9.7 months, compared with as much as 8.9 months for patients on chemotherapy alone.

In terms of one-year survival, it was 39.6 percent for those getting Avastin and chemotherapy and 40.1 percent for chemotherapy alone.

When they took into account demographic and clinical characteristics in adjusted models, the researchers did not find a significant difference in overall survival between patients treated with Avastin and chemotherapy and those treated only with chemotherapy.

Dr. Norman Edelman, chief medical officer of the American Lung Association, said, "As I pointed out in the past, it is important to study ways to extend quality of life in advanced lung cancer."

This study shows that a drug that was useful in a general age group is not effective in an older age group, he added. "Thus, it may save older patients exposure to an ineffective drug with side effects," he said.

"It is critical that, to the extent possible, we study treatments separately in groups known to differ in responses, rather than subject all to average responses," he said.

More information

For more information on lung cancer, visit the U.S. National Cancer Institute.

SOURCES: Deborah Schrag, M.D., M.P.H., Adult Oncology, Dana-Farber Cancer Institute, Boston; Norman Edelman, M.D., chief medical officer, American Lung Association; April 17, 2012, news release, Genentech; April 18, 2012, Journal of the American Medical Association


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. More Fake Avastin Found in U.S., FDA Says
2. Avastin May Be Helpful Before Breast Cancer Surgery
3. Avastin, Sutent increase breast cancer stem cells, U-M study shows
4. Avastin May Help Some With Ovarian Cancer: Studies
5. Avastin Boosted Survival for Type of Aggressive Breast Cancer: Study
6. FDA Revokes Approval of Avastin for Breast Cancer
7. Clinical trial shows benefit to adding avastin to neoadjuvant chemotherapy in breast cancer patients
8. Avastin Rejection Supported by Cancer Experts
9. FDA Panel Rejects Avastin for Breast Cancer
10. Cancer Drug Avastin Makes Inroads Against Ovarian Tumors
11. NIH study finds Avastin and Lucentis are equally effective in treating AMD
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Avastin No Benefit to Older Lung Cancer Patients: Study
(Date:5/26/2016)... ... May 26, 2016 , ... On May 23rd during the National ... Science® and international water advocate, was honored by Ashram, Inc. as the world’s foremost ... who knelt on the banks of the Nile to fill their red clay pots ...
(Date:5/26/2016)... ... May 26, 2016 , ... The introduction of our ... PROTECTION TO YOUR HEAD ™”. , “We are proud to introduce Meghan ... football front we have Brian Quick, wide receiver for Los Angeles who was a ...
(Date:5/26/2016)... ... 26, 2016 , ... Metcalf & Associates’ Maureen Metcalf ... experience in leading technology and human resources operations for health care, education, banking, ... be featured on Metcalf’s VoiceAmerica radio show , Innovative Leaders Driving Thriving ...
(Date:5/26/2016)... , ... May 26, 2016 , ... May 2016 – ... so central to popular cosmetic improvement efforts. Record numbers of clients now ask about ... prominent or pouty, says Kally Papantoniou, MD, of Advanced Dermatology P.C. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... is happy to announce the launch of its brand equity product, Brandvantage. ... to reflect the dynamic landscape of modern consumer decision-making. The proprietary framework ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... New Zealand , May 24, 2016 ... and informatics solutions for the healthcare sector, has been named ... New Zealand Hi-Tech Awards 2016. Dr Bruce ... fantastic acknowledgement for our team.  It,s really good to be ... burden healthcare internationally. Our products are used in 35 countries ...
(Date:5/24/2016)... Los innovadores de COMBO[TM], ... introduce catéteres para la intervención de extremidades inferiores ... global especializada en el suministro de soluciones vasculares ... incluyendo productos para tratar la enfermedad arterial periférica. ... los dispositivos de primera entrada de la compañía ...
(Date:5/23/2016)... , May 23, 2016 ... Handling Equipment Market by Product (Wheelchair, Scooters, Medical ... (Bariatric Care, Critical Care, Wound), Accessories (Lifting, Transfer) ... to 2021", published by MarketsandMarkets, the patient handling ... Billion by 2021 at a CAGR of 10.5% ...
Breaking Medicine Technology: