Navigation Links
Avandia Raises Risk of Heart Failure, Fractures
Date:6/5/2009

traindicated in heart failure and I doubt that this trial will lead the societies to change their recommendations that were based on many trials," he said.

And the findings are unlikely to quell an ongoing controversy about the safety of the drug, which was further fueled by a 2007 meta-analysis reporting a heightened risk of heart attacks with Avandia.

Although Home called that meta-analysis "weak," Dr. Steven Nissen, co-author of the 2007 paper and chairman of the department of cardiovascular medicine at the Cleveland Clinic, stated that the RECORD trial was "seriously flawed," citing the fact that more patients in the Avandia group were taking cholesterol-lowering statins and that group had what looked to be a high drop-out rate.

"Obviously, it is impossible to assess the safety of a drug when patients are not actually taking it," he said.

Avandia, one of a class of medications known as thiazolidinediones, is used to lower blood sugar in patients with type 2 diabetes in combination with two other drugs, metformin and sulfonylurea.

Several earlier studies had suggested that the risk for heart failure, death and heart attack was increased with Avandia, touching off a controversy that resulted in new U.S. Food and Drug Administration-mandated label warnings about the drug.

In 2008, the advocacy group Public Citizen called for a ban on the drug, just as an American Diabetes Association/European Association for the Study of Diabetes working group unanimously advised against the use of the drug.

Presented Friday at the ADA meeting were the final results of the RECORD trial, which involved 4,447 patients with type 2 diabetes, randomly selected to take Avandia plus metformin and sulfonylurea or just metformin and sulfonylurea.

"There was better persistence of glucose control over a course of five years, an approximate doubling in heart failure and a probability that it increased death from he
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Avandia Attorney Says Study Based on Useless Trick Science
2. Halting Avandia Use Hikes Blood Sugar Levels
3. LegalView Updates Avandia Information Portal With New Articles Detailing Potentially Dangerous Side Effects
4. Avandias Heart Risk Higher Than Others in Its Class
5. Public Citizen Petitions FDA to Ban Diabetes Drug Avandia, According to Avandia Plaintiffs Attorney Group
6. Consumer Group Seeks FDA Ban on Avandia
7. LegalView Re-Launches its Avandia Information Portal with News of the Type 2 Diabetes Drug's Risks and Dangers
8. Concern From Doctors Regarding the Cardiovascular Safety of GlaxoSmithKlines Avandia Increases Nine-Fold Following Publication of Meta-Analysis
9. Avandia May Slow Atherosclerosis After Bypass Surgery
10. Older Diabetics Using Avandia Face Increased Death Risk
11. Safety Concerns Prompt Prime to Remove Avandia(R) from Formulary
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Avandia Raises Risk of Heart Failure, Fractures
(Date:12/26/2014)... (PRWEB) December 26, 2014 Pentec Health, ... in the state of Pennsylvania for 2014. The awards ... statewide programs of its kind in the country. The ... the Pennsylvania Department of Community and Economic Development, the ... Management and the Central Penn Business Journal. ...
(Date:12/25/2014)... 26, 2014 The click ... beauty, strength and durability. Today, the business announces ... is valid until Jan. 30, 2015. , Click ... traditional hardwood. BambooFlooringChina.com is a well-known brand in ... worldwide to find a reliable bamboo flooring supplier. ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 Recently, iFitDress.com, the ... for women, has announced its new selection of black ... are on sale now; they are available at discounted prices, ... says, “The promotion will last for three weeks only. You ... market. Those who are interested in our new items can ...
(Date:12/25/2014)... Helen Harris’ RP (Retinitis Pigmentosa) International ... after an 8 year battle with breast cancer. ... in her home in Woodland Hills California after an ... , As the founder and volunteer President ... and championed many of today's greatest breakthroughs in restoring ...
(Date:12/25/2014)... (HealthDay News) -- Overeating is common during the holidays, but ... an expert says. "Don,t arrive at a party hungry. ... know you,ll be attending a party, but deprivation leads to ... at Northern Westchester Hospital in Mount Kisco, N.Y., said in ... during the day and even to have a snack before ...
Breaking Medicine News(10 mins):Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4
... 24, 2011David Satcher, MD, PhD, former U.S. Surgeon General, describes ... and adult health that we are facing today," calling for ... in the June issue of Childhood Obesity , a ... is available online. A long-time advocate in the ...
... , FRIDAY, June 24 (HealthDay News) -- Drinking even ... concentrations enough to increase the chances of being seriously injured ... get behind the wheel, a new study suggests. Researchers ... a blood-alcohol concentration of just 0.01 percent -- much lower ...
... June 24, 2011 A new anti-inflammatory drug used by ... a year-long study involving researchers from UT Southwestern Medical Center. ... Journal of Medicine , mark the first time a drug ... type 2 diabetes and chronic kidney disease. Previous studies have ...
... Researchers from Boston University,s Slone Epidemiology Center have found ... (MHC) that confer a higher risk of systemic lupus ... currently appears on-line in Human Genetics , is ... association between genetic variants in the MHC region and ...
... , THURSDAY, June 23 (HealthDay News) -- After suffering a ... and fears about the future are less depressed and live ... In fact, 48 percent of the people who participated in ... were not depressed a year later, compared to 37.7 of ...
... (HealthDay News) -- New research suggests that the adverse effects ... latest findings, from a University of Rhode Island study that ... revealed that preemies grow up to be less healthy, struggle ... compared to those born full-term. One reason for this, ...
Cached Medicine News:Health News:Even One Glass of Beer, Wine Boosts Car Crash Risk: Study 2Health News:Drug shows improved kidney function for type 2 diabetics, UT Southwestern researchers report 2Health News:New genetic risk factors of lupus found in study of African-American women 2Health News:Early Talk Therapy May Help Stroke Patients Bounce Back 2Health News:Early Talk Therapy May Help Stroke Patients Bounce Back 3Health News:Effects of Premature Birth May Stretch Into Adulthood: Study 2
(Date:12/24/2014)... , Dec. 24, 2014  Novastem, a leader ... first patient in its study for ischemic stroke ... Stroke Association, ischemic strokes account for 87 percent ... qualified patients in the study, entitled "Internal Research ... Allogeneic Mesenchymal Stem Cells and Intrathecal Administration of ...
(Date:12/24/2014)... N.J. , Dec. 24, 2014 ... a late-stage biopharmaceutical company developing products that address ... oncology and biodefense, announced today that on December ... public offering. The Company raised approximately ... and intends to use the net proceeds from ...
(Date:12/24/2014)... and LONDON , December ... orthopedic industry are expected to grow at an average ... terms of value and volume. Hip, knee and spine ... world while in emerging economies they have a lower ... are challenging the use of composites. Non-metallic orthopedic devices ...
Breaking Medicine Technology:Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 3Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 4Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3
... 2011 Today, at the American Society for Microbiology ... Molecular presented data showing the unique power of the ... disease-causing pathogens to help aid in the bioforensic analysis ... at the conference, Tim Motley, principal scientist, Ibis Biosciences, ...
... WASHINGTON, Feb. 7, 2011 Abbott (NYSE: ... PLEX-ID™ Biothreat Assay, which is designed to detect and ... and accurate detection of potentially dangerous microorganisms that could ... other resources. "While public health officials concerned ...
Cached Medicine Technology:Abbott's Ibis Technology Identified Fatal Disease Organism in Afghanistan 2Abbott's Ibis Technology Identified Fatal Disease Organism in Afghanistan 3Abbott Introduces Biothreat Assay for PLEX-ID™ System 2Abbott Introduces Biothreat Assay for PLEX-ID™ System 3
... designed to address customer requests for another ... even wider range of clinical applications in ... flow imaging with super-high frame rates to ... a wealth of technological innovations that enhance ...
... In the Innova™ 4100, the ... X-ray system for angiographic imaging, ... piece, non tiled Digital Detector ... reliably provide high resolution imaging ...
... you perform exams from cardiac to angio. ... no compromises. An ideal 31 centimeters square, ... of cardiovascular and interventional imaging. With a ... variety of vascular and interventional procedures. The ...
... vasopressin (AVP), also known as Antidiurectic Hormone ... is transported via exonal flow to the ... AVP secretion is regulated by changes in ... respond to alterations in blood volume or ...
Medicine Products: