Navigation Links
Automating laboratory-on-a-chip to cut healthcare costs

RIVERSIDE, Calif A research team at the University of California, Riverside has created a computer programming language that will automate "laboratory-on-a-chip" technologies used in DNA sequencing, drug discovery, virus detection and other biomedical applications.

A laboratory-on-a-chip is a device that integrates laboratory functions on a chip that is only millimeters or centimeters in size. The technology allows for the automation and miniaturization of biochemical reactions. It has the potential and to improve and reduce the cost of healthcare.

"If you think of the beginning of computers they were basically tools to automate mathematics," said Philip Brisk, an assistant professor in the Department of Computer Science and Engineering at UC Riverside's Bourns College of Engineering. "What are we are creating is devices that could automate chemistry in much the same way."

The most recent laboratory-on-a-chip devices are equipped with integrated electronic sensors, similar in principle to those used in today's smart phones and tablet PCs. These sensors enable scientists and health care professionals working with the devices to analyze the sensor data to make informed decisions about future analyses to perform.

Brisk and his research team are funneling the sensor data into a computer, facilitating automated decision making, rather than employing a human-in-the-loop.

"We are really trying to eliminate as much human interaction as possible," Brisk said. "Now, you have a chip, you use it and then you analyze it. Through automation and programmability, you eliminate human error, cuts costs and speed up the entire process."

Brisk's findings were recently published in a paper, "Interpreting Assays with Control Flow on Digital Microfluidic Biochips," in ACM Journal on Emerging Technologies in Computing Systems.

There were two co-authors: Daniel Grissom, one of Brisk's Ph.D. students; and Christopher Curtis, who worked with Brisk for three years as an undergraduate and plans to return as a Ph.D. student in the fall.

The team started with an existing biological programming language, BioCoder, developed by Microsoft's research office in India. It was originally created to improve the reproducibility and automation of biology experiments by using a programming language to express the series of steps taken.

The UC Riverside team modified BioCoder to process sensor feedback in real-time. Using a software simulator to mimic the behavior of a laboratory-on-a-chip, they proved it works. Now, in conjunction with William Grover, an assistant professor of bioengineering at UC Riverside, they plan to build a prototype chip that can be used for real world applications.

This research is supported by the National Science Foundation under grant CNS-1035603, an NSF Graduate Research Fellowship awarded to Grissom, and a UC Riverside Dissertation Year Fellowship, also awarded to Grissom, who completes his Ph.D. in June, 2014.

Brisk was also recently awarded a five-year, $493,645 National Science Foundation CAREER grant for related research to apply semiconductor design automation and layout principles to laboratory-on-a-chip technology.


Contact: Sean Nealon
University of California - Riverside

Related medicine news :

1. NetPlus to Give Highly Anticipated Session on Automating VoIP & UC Transitions at IAUG Converge2013 on Monday, June 3rd
2. Freeslate Launches New CM Protégé Bioformulation Assessment Systems, Automating Visible Particle Detection, pH, and Viscosity Measurements
3. Weill Cornell Medical College establishes Center for Healthcare Informatics and Policy
4. Coral Calcium Company Announces New Offer Amidst Supreme Court Healthcare Decisions
5. Healthcare researchers recognized at SingHealth Duke-NUS Scientific Congress 2012
6. Daily disinfection of isolation rooms reduces contamination of healthcare workers hands
7. Health inequalities could be reduced by more effective healthcare, says new study
8. Healthcare ethics consultants share lessons learned
9. Kessler Foundation stroke expert receives $145,000 grant from Healthcare Foundation of New Jersey
10. Social environmental factors affect rehospitalization risk in home healthcare patients
11. TGen, Scottsdale Healthcare lead worldwide study of new drug for patients with pancreatic cancer
Post Your Comments:
Related Image:
Automating laboratory-on-a-chip to cut healthcare costs
(Date:11/30/2015)... ... November 30, 2015 , ... An ... directory is specialized and only includes chiropractic clinics in the US. , The ... trustworthy alternative health practitioner when back pain sets in. When people are experiencing ...
(Date:11/30/2015)... ... November 30, 2015 , ... In ... Halloween festivities, the Word of Life Christian Church of Flint, MI, hosted a ... a giant 1.25 ton pile of candy dubbed “Candy Mountain”. , A Forever ...
(Date:11/30/2015)... ... November 30, 2015 , ... During ... fundraising campaign to raise funds for its research, education, support, and advocacy efforts. ... organization’s annual funding. , The Mesothelioma Applied Research Foundation, which also goes by ...
(Date:11/30/2015)... ... November 30, 2015 , ... The ... in Dallas, TX, on January 29 and 30, 2016. The course welcomes dental ... of their practices, to learn how to better succeed in the modern dental ...
(Date:11/30/2015)... ... November 30, 2015 , ... HemoTreat™ has announced that the ... ointment to its website. , “Our goal is simple:” says Michael Blasco, HemoTreat’s ... the comparison chart and ingredient list allows our customers to quickly see why, ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... Free Press as a Top Workplace , among the ... work for in 2015. ... annually, based on employee surveys rating company leadership, career opportunities, ... based solely on employee feedback. The survey is conducted by ...
(Date:11/30/2015)...  IBA Molecular North America, Inc. (IBAMNA), a U.S. ... that as of January 1, 2016, it will do ... to rebrand the company reflects a refined vision for ... close relationship with Zevacor Molecular.  Both IBAMNA and Zevacor ... Peter Burke , Vice President Sales ...
(Date:11/30/2015)... 30, 2015 Baxalta Incorporated (NYSE: ... dedicated to delivering transformative therapies to patients ... today announced the launch and first shipments ... extended circulating half-life recombinant factor VIII (rFVIII) ... ADVATE [Antihemophilic Factor (Recombinant)]. The treatment was ...
Breaking Medicine Technology: