Navigation Links
Automated screening process may eventually reduce additional breast cancer surgeries
Date:1/30/2009

A team of researchers at the University of California, San Diego (UCSD) and the Moores UCSD Cancer Center have developed a rapid, automated image screening process to distinguish breast cancer cells from normal cells. The technique, which is based on the density of cells seen on a microscope slide, may eventually lead to better ways for surgeons to determine if they have removed all of the cancer during breast-conserving cancer surgery and cut down on the number of needed second operations.

One of the biggest dilemmas in breast-conserving "lumpectomies" is whether or not all of the cancer has been removed. To find out, pathologists examine the tissue, looking for cancer cells from the outer margins. But this process is slow, taking up to a week. All too often between 20 and 50 percent of the time some disease remains, meaning more surgery.

"The majority of women are good candidates for breast conservation surgery," said breast surgeon Sarah Blair, MD, associate clinical professor of surgery at the UC San Diego School of Medicine, who led the work. "The problem is getting negative margins meaning the edge of what we remove has no cancer the first time we operate because we are dealing sometimes with small tumors that can be difficult to see or feel. Right now there is no good way during the operation to make sure that we have removed every cancer cell. We'd like to reduce the need for second operations, which will spare the patient the trauma of surgery again and reduce costs."

Reporting in the Annals of Surgical Oncology, Blair and her co-workers examined samples of normal breast tissue from 10 women and tumor samples from 24 women with cancer. They showed that a technique called automated microscopy, with the help of specially designed computer software, could correctly identify invasive breast cancer cells in 83 percent of the tumor specimens, whereas a normal microscope only identified cancer in 65 percent of the cancer specimens.

The researchers used a method called "touch prep" to collect the cancer cells for evaluation, which entails gathering cells to be stained and then examined and which normally requires a specialized pathologist to subjectively interpret. But in this case, the scientists used the center of the tumor, rather than the outer tissue edges, where it is more difficult to identify cancer cells, to confirm that the technique actually worked.

"We compared manual microscopy, looking at the tissue cells on a slide under the microscope, with automated programs, in which we taught a computer how to look at the slides with a microscope, and they correlated pretty well," Blair said. A camera connected to the microscope takes photos of the slide, which are then analyzed for cancer. "We thought that if we automated it, we could teach the computer what to look for and have the pathologist quickly correlate the computer findings with their findings. We're hoping that the method makes the process more objective."

According to Blair, the automated technique is still too slow to be used in real time during breast surgery. Each slide of breast tissue cells takes about two hours to be analyzed, she said, and six slides are typically examined during breast conservation surgery. They would like to reduce the analysis time to as little as five minutes per slide, and based on the results, know whether or not the patient needs further surgery while she is still in the operating room.

As the researchers continue to refine the technique, they will be able to eventually test its use in examining breast tissue margins. Because it is difficult to identify preinvasive cancer cells, she said, they also want to look at cell surface markers and cell nucleus characteristics to better identify cancer cells and help speed up the identification process. The findings are still preliminary, and Blair and her co-workers are planning to conduct a larger, multicenter trial of the automated technique.


'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Paragon Technologies SI Systems Brand Awarded A $1.0 Million System Expansion Contract for an Automated Light-Picking System
2. Vocantas CallAssure provides hospitals with automated solution for post-discharge patient follow-up
3. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
4. Medco to Build Worlds Largest, Most Advanced Automated Pharmacy in Central Indiana
5. New Automated System IDs Victims of Mass Disasters in Minutes
6. New Automated System Can ID Disaster Victims in Minutes
7. Omnicell Debuts Industrys First Total Automated Patient-Specific Management Solution
8. Procedure to detect fetal heart defects is first automated use of 3-D ultrasound
9. Medco Breaks Ground For Worlds Largest Automated Pharmacy
10. World first: researchers develop completely automated anesthesia system
11. Quest Diagnostics Chooses Roches Fully Automated, Real-Time HIV-1 Viral Load Monitoring Test For Its Customers in Laboratories Nationwide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... NASHVILLE, Tenn. (PRWEB) , ... February 10, 2016 ... ... by the American Academy of Emergency Medicine , an emergency medicine ... of practice management services . , The American Academy of Emergency Medicine, ...
(Date:2/10/2016)... ... 2016 , ... 10 Best Water is excited to announce a ... owners that topped the list as a result of their commitment to offering clients ... was Tibet 5100, a top notch water company that specializes in providing the public ...
(Date:2/10/2016)... ... February 10, 2016 , ... Intalere’s 2016 Executive Forum, ... 200 of the country’s top healthcare executives to share insights on transformational strategies ... the Forum is the provider-centric perspective, experience, expertise and strategy shared by the ...
(Date:2/10/2016)... KALAMAZOO, MI (PRWEB) , ... February 10, 2016 , ... ... offer Apifiny® across their network of laboratory service centers across the country. ... designed to aid clinicians in the detection of prostate cancer. Apifiny order volume exceeded ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... will attend the Ohio Safety Congress and Expo event March 9-11, 2016. Hosted ... Greater Columbus Convention Center. , As the longest running and largest worker's ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... -- Antibacterial Drugs Market - Global Industry Analysis, ... reveals that the global antibacterial drugs market is forecast to ... to patent expiries of blockbuster drugs. Even though the market ... period, the value is anticipated to decline from US$43.9 bn ... Antibacterial Drugs Market - Global Industry Analysis, Size, Share, Growth, ...
(Date:2/10/2016)... KANSAS CITY, Mo. , Feb. 10, 2016 ... the pharmaceutical industry, recently identified an industry-wide trend ... a tool that allows organizations to efficiently deliver ... surveys, one in 2011 and another in 2015, ... are armed with tablet devices and DSAs, many ...
(Date:2/10/2016)... Feb. 9, 2016 On Tuesday, ... (FDA) met with its Arthritis Advisory Committee ... of Johnson & Johnson,s Remicade and most ... in the U.S. The Biologics Prescribers Collaborative ... - Alliance for Patient Access, American Association ...
Breaking Medicine Technology: