Navigation Links
Automated MRI technique assists in earlier Alzheimer's diagnosis
Date:6/23/2008

OAK BROOK, Ill. An automated system for measuring brain tissue with magnetic resonance imaging (MRI) can help physicians more accurately diagnose Alzheimer's disease at an earlier stage according to a new study published in the July issue of the journal Radiology.

In Alzheimer's disease, nerve cell death and tissue loss cause all areas of the brain, especially the hippocampus region, to shrink. MRI with high spatial resolution allows radiologists to visualize subtle anatomic changes in the brain that signal atrophy, or shrinkage. But the standard practice for measuring brain tissue volume with MRI, called segmentation, is a complicated, lengthy process.

"Visually evaluating the atrophy of the hippocampus is not only difficult and prone to subjectivity, it is time-consuming," explained the study's lead author, Olivier Colliot, Ph.D, from the Cognitive Neuroscience and Brain Imaging Laboratory in Paris, France. "As a result, it hasn't become part of clinical routine."

In the study, the researchers used an automated segmentation process with computer software developed in their laboratory by Marie Chupin, Ph.D., to measure the volume of the hippocampus in 25 patients with Alzheimer's disease, 24 patients with mild cognitive impairment and 25 healthy older adults. The MRI volume measurements were then compared with those reported in studies of similar patient groups using the visual, or manual, segmentation method.

The researchers found a significant reduction in hippocampal volume in both the Alzheimer's and cognitively impaired patients when compared to the healthy adults. Alzheimer's patients and those with mild cognitive impairment had an average volume loss in the hippocampus of 32 percent and 19 percent, respectively. Studies using manual segmentation methods have reported similar results.

"The performance of automated segmentation is not only similar to that of the manual method, it is much faster," Dr. Colliot said. "It can be performed within a few minutes versus an hour."

According to the Alzheimer's Association, more than five million Americans currently have Alzheimer's disease. One of the goals of modern neuroimaging is to help in the early and accurate diagnosis of Alzheimer's disease, which can be challenging. When the disease is diagnosed early, drug treatment can help improve or stabilize patient symptoms.

"Combined with other clinical and neurospychological evaluations, automated segmentation of the hippocampus on MR images can contribute to a more accurate diagnosis of Alzheimer's disease," Dr. Colliot said.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Paragon Technologies SI Systems Brand Awarded A $1.0 Million System Expansion Contract for an Automated Light-Picking System
2. Vocantas CallAssure provides hospitals with automated solution for post-discharge patient follow-up
3. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
4. Medco to Build Worlds Largest, Most Advanced Automated Pharmacy in Central Indiana
5. New Automated System IDs Victims of Mass Disasters in Minutes
6. New Automated System Can ID Disaster Victims in Minutes
7. Omnicell Debuts Industrys First Total Automated Patient-Specific Management Solution
8. Procedure to detect fetal heart defects is first automated use of 3-D ultrasound
9. Medco Breaks Ground For Worlds Largest Automated Pharmacy
10. World first: researchers develop completely automated anesthesia system
11. Quest Diagnostics Chooses Roches Fully Automated, Real-Time HIV-1 Viral Load Monitoring Test For Its Customers in Laboratories Nationwide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... ... time when tampons and pads were the only options for women for period protection. But ... Lunette . To make that time of the month less of a pain and more ... , It’s easy to see why Lunette is so popular. Lunette cups are eco-friendly, ...
(Date:5/25/2016)... ... May 25, 2016 , ... Today ... Herbert Wertheim College of Medicine announced the AUA-FIU Global MD Program. Students ... Health Certificate from AUA and a Certificate of Completion from the FIU Herbert ...
(Date:5/25/2016)... ... 2016 , ... CloudLIMS, joins an elite number of companies that have earned ... of 2016 by CIOReview. , In a deliberate session with the honorary industrial experts, ... has been concluded with. The positioning is based on evaluation of CloudLIMS’ specialties in ...
(Date:5/25/2016)... , ... May 25, 2016 , ... Cheryl Bowker of ... to bestow: the Dick McKenna Good Hands Legacy Award. McKenna ran one of Allstate’s ... which continues to inspire all those who knew him. The award named for him ...
(Date:5/25/2016)... ... May 25, 2016 , ... Afrimesure specializes in ... and pharmaceutical, to food and HVAC facilities. Their knowledgeable staff also takes care ... For medical applications, Afrimesure offers a variety of MadgeTech systems available for sterilization ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... -- Niederländische Chirurgen haben eine innovative ... erlaubt, ihre Expertise weltweit zu teilen und so ... mit einer Instant-Messaging-Funktion und der Möglichkeit, in einem ... Afrika, Asien und den USA ... Information und Weiterbildung   "MDLinking ...
(Date:5/24/2016)...   , Study met both ... in , Excellent plus Good ... of the ascending colon   ,      ... announced new positive data from the phase III MORA study for ... litre PEG with ascorbate. The study met both primary endpoints showing ...
(Date:5/24/2016)... May 24, 2016  NxStage Medical, Inc. (Nasdaq: ... on advancing renal care, today announced that Jeffrey ... in the following schedule of investor conferences. Where applicable, ... at http://ir.nxstage.com/ .   ... Conference NY, NY           Friday, June 10, 2016 1:30 ...
Breaking Medicine Technology: