Navigation Links
Autoimmune Disease Treatment May Not Dampen Immune System
Date:6/19/2008

disease and are generally quite effective, said Rose.

Still, they are not perfect.

"The problem with that treatment is it is not effective against all autoimmune diseases," he said. "But more importantly, it may predispose to infection, because you downgrade the entire inflammatory response."

Siegel, with colleagues at the U.S. National Institute of Allergy and Infectious Diseases and at Cardiff University in Wales, U.K., asked what would happen to mouse models of asthma and multiple sclerosis that were genetically engineered to lack DR3. (Asthma is an inflammatory condition largely attributed to a subset of T-cells called Th2; multiple sclerosis is an autoimmune disorder caused by two different T-cell populations, Th1 and Th17.)

The answer: Both disease pathologies were "reduced" in the DR3-deficient mice, said Siegel, and fewer T-cells were found in the tissues that should have been affected. Yet, the DR3-deficient animals did not suffer from a generalized immunodeficiency and thus were able to mount immune responses to both a chicken egg protein and the parasite that causes toxoplasmosis.

"The essence of the paper is that not only are DR3-deficient mice not horribly immunodeficient," said Siegel, "if you look at their immune system in general, it is normal."

Indeed, the animals appeared to have no shortage of T-cells capable of responding to the inflammation-inducing antigens. Instead, for whatever reason, they were not being activated and dividing in the tissues normally affected by disease (such as the lung in the asthma model).

"It looks as if, for reasons this article does not make clear, the cells do not proliferate in the target organ," said Rose. "They can proliferate elsewhere, but they do not elicit an inflammatory response in the target organ."

Siegel said the combination of anti-inflammatory activity in DR3-deficient mice with sustained immune system function is u
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Specific location of the TRAF1/C5 gene associated with multiple autoimmune diseases
2. FDA Starts Safety Review of Autoimmune Disorder Drugs
3. Weizmann Institute scientists develop a new approach to treating autoimmune disease
4. AutoImmune Inc. Reports 2008 First Quarter Financial Results
5. Mergent, Inc. Announces Changes to the HealthShares(TM) Composite, Enabling Technologies, Autoimmune-Inflammation, Cancer, Cardiology and Neuroscience Indexes
6. Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk
7. New protein discovery helps researchers understand autoimmune diseases
8. AutoImmune Inc. Reports 2007 Third Quarter Financial Results
9. Occupational exposures may be linked to death from autoimmune disease
10. M.D. Anderson-led team reports possible key to autoimmune disease
11. New research on mutation in yeast can enhance understanding of human diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Autoimmune Disease Treatment May Not Dampen Immune System
(Date:4/22/2014)... The risk of pregnancy among women using a newer ... than 10 times greater over a 10-year period than ... by researchers at Yale University and UC Davis has ... journal Contraception , the study found the higher ... under the brand name Essure. , "This study ...
(Date:4/22/2014)... The International Communication Association will hold its 64th ... theme of the 2014 conference will explore what ... digital society. , Featuring over 2,300 academic papers ... scholars representing over 40 countries, the ICA conference ... the world. This year,s conference features sessions that ...
(Date:4/22/2014)... the standard measurement for assessing glycemic control over time ... typically measured every few months in a laboratory, but ... estimates A1c using self-monitored blood glucose (SMBG) readings, as ... DTT ), a peer-reviewed journal from Mary Ann Liebert, ... DTT website at http://www.liebertpub.com/dtt . , ...
(Date:4/22/2014)... Sophia Antipolis, 22 April 2014. The latest scientific advances ... at Heart Failure 2014, the main annual meeting of ... of Cardiology (ESC). Journalists will also hear breaking news ... on Acute Heart Failure, which is part of the ... May in Athens, Greece, at the Megaron Athens International ...
(Date:4/22/2014)... developed at the University of Utah (U of U) ... three separate cases, U of U researchers and their ... American Journal of Human Genetics . The software, Phevor ... and unknown gene mutations by analyzing the exomes, or ... are made, in individual patients and small families. ...
Breaking Medicine News(10 mins):Health News:Risk of pregnancy greater with newer method of female sterilization 2Health News:Risk of pregnancy greater with newer method of female sterilization 3Health News:International Communication Association to hold Annual Conference in Seattle, Washington 2Health News:The world's largest heart failure congress 2Health News:The world's largest heart failure congress 3Health News:Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses 2Health News:Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses 3
... heart attack and stroke, increases with high blood glucose, ... these values to ideal levels. According to researchers at ... be as simple as seeing your doctor. They found ... of blood glucose, blood pressure and cholesterol treatment goals. ...
... People may be learning while they,re sleeping ... well understood, according to a study by Michigan State ... Journal of Experimental Psychology: General. "We speculate that ... distinct from traditional memory systems," said Kimberly Fenn, assistant ...
... research shows liver transplantation candidates without hepatocellular carcinoma (HCC) ... liver transplant (LDLT) than waiting for a deceased donor ... October issue of Hepatology, a journal published by Wiley-Blackwell ... of Liver Diseases, reports that survival benefit from LDLT ...
... By Amanda Gardner HealthDay Reporter , MONDAY, Sept. 26 ... or more cups of caffeinated coffee daily seem to have a ... stop at one cup a day, a new study suggests. ... as a way to prevent depression, the findings may comfort those ...
... livestock farms cause asthma and COPD patients living nearby ... at the European Respiratory Society,s Annual Congress in Amsterdam. ... and goat farms increased with the number of animals ... found, hinting at higher health risks from ,mega farms,. ...
... Media have less than three weeks to register ... Multidisciplinary Cancer Congress in Stockholm, 23-27 September 2011. ... European Multidisciplinary Cancer Congress will take place at ... www.stofair.se ) from Friday 23 September to Tuesday ...
Cached Medicine News:Health News:Frequent doctor visits benefits patients with diabetes 2Health News:Living donor liver transplantation improves survival over deceased donor transplants 2Health News: Lots of Coffee Might Lower Depression Risk: Study 2Health News: Lots of Coffee Might Lower Depression Risk: Study 3Health News:Environmental health risks of livestock farming 2Health News:Media have less than 3 weeks to register for the European Multidisciplinary Cancer Congress 2011 2Health News:Media have less than 3 weeks to register for the European Multidisciplinary Cancer Congress 2011 3
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... market research report is available in ... Global Markets and Technologies for Advanced ... Routes of Administration ...
(Date:1/14/2014)... Jan. 14, 2014 HeartWare International, Inc . ... less invasive, miniaturized circulatory support technologies that are revolutionizing ... it expects revenues for the fourth quarter of 2013 ... revenues to approximately $208 million. "Our full-year ...
(Date:1/14/2014)... The Brandeis Medical Center, led by Dr. Emmanuel Brandeis ... affordable laser tattoo removal experience with the advanced Astanza Duality laser ... high quality cosmetic services with cutting edge medical technology and offering ... California has seen a dramatic increase in the presence ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2
... Aug. 17 In response to unprecedented devastation and human ... Foundations today announced it would give an additional $5 million ... "We need everyone to pitch in to the ... Open Society Foundation in Pakistan – FOSI-Pakistan. "While the government ...
... FEICHENG, China, Aug. 17 /PRNewswire-Asia-FirstCall/ -- ... ... var shortURL ... by longUrl, so we need to grab the first one. for (var r in data.results) { ...
Cached Medicine Technology:George Soros to Boost Civil Society Response in Flood Affected Areas of Pakistan 2China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 2China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 3China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 4China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 5China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 6China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 7China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 8China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 9China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 10China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 11China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 12China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 13China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 14China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 15
... Available in small and large sizes, ... popular, easy-to-place, silver/silver chloride disposable tabs. For ... 17). Dimensions (contact surface): large tabs-2.2 x ... tabs-1.5 cm (0.5 in) square. Each 100-count ...
... Symphony orchestrates images and patient information ... information sources in one central system. ... and improves cost-effectiveness so that healthcare ... do best, helping people., ,Many Sources, ...
... Maxenon Xi300 is so bright many surgeons turn ... gears to shift into when the going gets ... as a true Hot Start and the technologically ... system that prevent failed start ups and overheating. ...
Mounted on a sturdy, molded headband,the Classic has a fully adjustable crown,strap and cushioning that adds to,your comfort....
Medicine Products: