Navigation Links
Autoimmune Disease Treatment May Not Dampen Immune System
Date:6/19/2008

Targeting a key protein might reap rewards for people with asthma, MS, scientists say

THURSDAY, June 19 (HealthDay News) -- Researchers have uncovered cellular proteins that may be key to certain autoimmune and inflammatory diseases, according to a new study.

The findings, performed so far only in mice, point to potential new treatments for a range of human diseases that are mediated by immune system T-cells. These include many inflammatory and autoimmune disorders, illnesses that involve an immune system run amok.

More important, such a treatment might provide patients with all the benefits of existing drugs, without the general immune suppression that often accompanies them.

"It has an effect on an autoimmune disease -- a mouse model of multiple sclerosis -- and an inflammatory disease -- a mouse model of asthma -- but does not seem to interfere with protective immunity against toxoplasma, a parasite," said one expert, Dr. Noel Rose, director of the Johns Hopkins Center for Autoimmune Disease Research in Baltimore.

"This is what everyone is driving for, to selectively block pathological [immune] responses but not normal responses," added the study's lead author, Dr. Richard Siegel of the U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases.

The findings were published in the July issue of Immunity.

At the center of this effort are a pair of proteins, DR3 and TL1A. Expressed on the surface of white blood cells called T lymphocytes, DR3 induces T-cells to proliferate and release inflammatory cytokines (signaling proteins) when it binds TL1A, which is like the "key" to DR3's "lock."

TL1A and DR3 are also related to tumor necrosis factor (TNF), and its receptor, respectively. TNF has been implicated in inflammatory and autoimmune disease, and drugs that target TNF and its receptor are used to treat rheumatoid arthritis and inflammatory bowel
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Specific location of the TRAF1/C5 gene associated with multiple autoimmune diseases
2. FDA Starts Safety Review of Autoimmune Disorder Drugs
3. Weizmann Institute scientists develop a new approach to treating autoimmune disease
4. AutoImmune Inc. Reports 2008 First Quarter Financial Results
5. Mergent, Inc. Announces Changes to the HealthShares(TM) Composite, Enabling Technologies, Autoimmune-Inflammation, Cancer, Cardiology and Neuroscience Indexes
6. Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk
7. New protein discovery helps researchers understand autoimmune diseases
8. AutoImmune Inc. Reports 2007 Third Quarter Financial Results
9. Occupational exposures may be linked to death from autoimmune disease
10. M.D. Anderson-led team reports possible key to autoimmune disease
11. New research on mutation in yeast can enhance understanding of human diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Autoimmune Disease Treatment May Not Dampen Immune System
(Date:8/1/2015)... (PRWEB) , ... August 02, 2015 , ... AlignLife ... which will help the continuity of care for patients at this natural health care ... the unknown," Clinic Director Mary Heal said. "Heather's role is vital to our approach ...
(Date:8/1/2015)... ... 2015 , ... Calvary Hospital today announced that it is embarking on a ... is to bring this Torah – dating from 1880 – back to kosher status, ... , Scroll No. 515, from the town of Taus-Domazlice, is on permanent loan ...
(Date:8/1/2015)... Atlanta, GA (PRWEB) , ... August 01, 2015 , ... ... iPhone app that is free to download on the Apple AppStore. , The ... energy levels, even mood, thus acting as a tool to view personal health and ...
(Date:7/31/2015)... ... ... a reputable source of authentic tickets for the 2015 iHeart Radio Music Festival ... music will have an act they are excited to see at this two-day festival. ... perform: Sam Smith, Coldplay, Kenny Chesney, The Who, Jason Derulo, Demi Lovato, Duran Duran, ...
(Date:7/31/2015)... ... ... Precision Aesthetics is New York’s only Thermage skin tightening pinnacle and black diamond award ... fat reduction in New York. Due to its unparalleled level of experience for ... patients travel to New York to get their non-surgical skin tightening and body shaping ...
Breaking Medicine News(10 mins):Health News:New Patient Advocate Enhances Natural Health Care 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 3Health News:Lume Wellness Launches Health and Fitness Tracker iPhone App 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3
... , , NEW YORK, Sept. 1 Empire ... status of "Excellent" for its HMO Commercial HMO/POS Combined and Medicare ... accreditation status - the highest possible level - is based on ... members receive access to high quality care. , , ...
... aggressive tumors if pounds mount up in 20s, 30s, study ... pack on excess pounds as young adults are at heightened ... ethnic group, researchers from the University of Hawaii report. , ... colorectal cancer and breast cancer in postmenopausal women. However, whether ...
... and Washington DC (1 September 2009) SAGE, the ... to announce a new agreement with the International Headache ... . Now in its 29th volume, Cephalalgia ... review articles and short communications on all aspects of ...
... 1, 2009 A recent study published in the ... correlation between being overweight, smoking and breast cancer. What ... not diagnosed for BRCA1 and BRCA2 gene mutations, which ... with such gene mutations were excluded to allow researchers ...
... , , Program Helps Teachers ... , WASHINGTON, Sept. 1 With worries about the ... Education Association Health Information Network (NEA HIN) and The Clorox Company are ... 2 through September 5, 2009, teachers nationwide can visit www.CloroxClassrooms.com ...
... , HARRISBURG, Pa., Sept. 1 ... interested in receiving pandemic H1N1 influenza vaccines and supplies when ... today. , , The Department of ... schools and community vaccinators. , , ...
Cached Medicine News:Health News:Empire Blue Cross Blue Shield Awarded NCQA's Accreditation Status of 'Excellent' 2Health News:Adult Weight Gain Tied to Prostate Cancer Risk 2Health News:SAGE to publish leading international headache journal Cephalalgia 2Health News:Breast cancer: Risk increases for smokers and overweight women 2Health News:National Education Association Health Information Network (NEA HIN) and The Clorox Company Offer Free Disinfecting Wipes to Teachers Nationwide 2Health News:National Education Association Health Information Network (NEA HIN) and The Clorox Company Offer Free Disinfecting Wipes to Teachers Nationwide 3Health News:Pennsylvania Department of Health Launches Online H1N1 Vaccine Registry 2
(Date:7/30/2015)...  Tandem Diabetes Care®, Inc. (NASDAQ: TNDM ... the t:slim® and t:flex™ Insulin Pumps, today announced ... with Dexcom, Inc. to allow the integration of ... G5 and G6 continuous glucose monitoring ("CGM") systems. ... with Dexcom,s future CGM systems is an important ...
(Date:7/30/2015)... VANCOUVER , July 30, 2015  OncoGenex Pharmaceuticals, ... will report its second quarter 2015 financial results on ... conference call and live webcast at 4:30 p.m. Eastern ... development programs and a general corporate update. ... Investor Relations page of the OncoGenex website at ...
(Date:7/30/2015)... July 30, 2015 Tianyin Pharmaceutical Inc. (NYSE ... that specializes in the patented biopharmaceutical, modernized traditional Chinese ... provided updates regarding the notice it received on May ... indicating that the Company was below certain of the ... 134 and 1101 of the NYSE MKT Company Guide, ...
Breaking Medicine Technology:Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3TPI Provides Update Regarding Non-Compliance with NYSE MKT Continued Listing Requirements 2
... CITY, Calif. and TORTONA, Italy, July 28, 2011 ... a global technology and engineering Company wholly-owned by Italy,s ... broad collaboration to develop and produce sustainable detergent alcohols ... includes development of second generation detergent alcohols from cellulosic ...
... Pa., July 28, 2011 McNeil Consumer ... for new dosing instructions lowering the maximum daily dose ... U.S. from 8 pills per day (4,000 mg) to ... designed to help encourage appropriate acetaminophen use and reduce ...
Cached Medicine Technology:Codexis and Chemtex to Collaborate on Sustainable Detergent Alcohols for the Household Products Market 2Codexis and Chemtex to Collaborate on Sustainable Detergent Alcohols for the Household Products Market 3Codexis and Chemtex to Collaborate on Sustainable Detergent Alcohols for the Household Products Market 4McNeil Consumer Healthcare Announces Plans for New Dosing Instructions for TYLENOL® Products 2McNeil Consumer Healthcare Announces Plans for New Dosing Instructions for TYLENOL® Products 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: