Navigation Links
Autoantibodies damage blood vessels in the brain
Date:7/31/2012

The presence of specific autoantibodies of the immune system is associated with blood vessel damage in the brain. These findings were made by Marion Bimmler, a graduate engineer of medical laboratory diagnostics at the Max Delbrck Center for Molecular Medicine Berlin-Buch and Dr. Peter Karczewski of the biotech company E.R.D.E.-AAK-Diagnostik GmbH in studies on a rat model. The researchers' results suggest that autoimmune mechanisms play a significant role in the pathogenesis and progression of Alzheimer's and vascular dementia (PloS ONE, doi:10.1371/journal.pone.0041602)*.

Antibodies are the defense molecules of the body's immune system against foreign invaders. If the antibodies cease to distinguish between "foreign" and "self", they attack the cells of the own body, and are thus referred to as autoantibodies. These can trigger autoimmune diseases. Using MR angiography and other methods, Marion Bimmler and her colleagues have now shown that the autoantibodies bind to specific surface proteins (alpha1 andrenergic receptors) of vascular cells and thereby damage the blood vessels of the brain. The reason: The autoantibodies generate a continual stimulation of the receptor and at the same time trigger an increase in intracellular calcium ion levels. As a result, the blood vessel walls thicken, and blood flow to the brain is disturbed.

First Encouraging Results after Removal of Autoantibodies by Immunoadsorption

In earlier studies, Marion Bimmler and her research team examined blood samples of patients with Alzheimer's or vascular dementia and showed that half of them had comparable autoantibodies. A first clinical trial together with Charit Universittsmedizin Berlin is currently ongoing with a collective of patients with Alzheimer's or vascular dementia. The patients were divided into two groups a small group whose autoantibodies were removed from the blood via immunoadsorption and a control group that did not receive this treatment. Until now, over an observation period of 6 and subsequently 12 months, the patient group who had undergone immunoadsorption improved in their memory performance and in their ability to cope with their everyday lives. In contrast, the condition of the patients who did not receive immunoadsorption treatment and continued to have autoantibodies in their blood deteriorated dramatically. Now the researchers are planning further clinical trials with larger numbers of patients.


'/>"/>

Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert  

Related medicine news :

1. Study finds novel therapy that may prevent damage to the retina in diabetic eye diseases
2. DNA damage in roofers due to PAH exposure - possible cancer link
3. Scientists discover melanoma-driving genetic changes caused by sun damage
4. Platelet-rich plasma therapy a safe option for cartilage damage, new study finds
5. UGA study shows why hypertension increases damage to eyes of diabetic patients
6. Sunburn May Help Rid Body of Radiation-Damaged Cells
7. Study of Retired NFL Players Finds Evidence of Brain Damage
8. Kernicterus Brain Damage in Babies Linked to Medical Malpractice
9. Germ Culprits in Moldy, Water-Damaged Buildings Identified
10. Weight-Loss Surgery May Improve Diabetes-Related Kidney Damage
11. Sleep Apnea May Be Linked to Nerve Damage in Diabetics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Autoantibodies damage blood vessels in the brain
(Date:5/4/2016)... , ... May 04, 2016 , ... May kicked off ... people across the United States. Dermatologist Dr. Ellen Turner is encouraging her patients, as ... advice and focus on skin safety and health now and in the future. , ...
(Date:5/4/2016)... ... , ... Recognizing that lifestyle medicine is essential to health and healthcare, ... Katz, MD, MPH, president of the American College of Lifestyle Medicine, as their first ... gratifying,” said Katz. “There is so much opportunity to add years to lives, and ...
(Date:5/4/2016)... ... 2016 , ... Bayco Products has announced the introduction of ... in models NSP-9842XL and NSR-9844XL . , First previewed at SHOT Show ... included CR-123 batteries to produce up to 650 lumens in a variety of ...
(Date:5/4/2016)... ... May 03, 2016 – (PRWEB) May 04, 2016 ... products, today revealed the non-toxic benefits of its Tutti Frutti line ... teething pain is just part of the story. These food-grade, silicone ... PVC-, and phthalate-free. , “Many baby toys contain BPA, harmful ...
(Date:5/4/2016)... ... 2016 , ... Fertility Centers of New England announced today the opening of ... Center provides convenient access to care for patients seeking fertility treatment in Maine. “We ... Comprehensive Care in Portland,” said Fertility Centers of New England President and CEO, Joseph ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... May 4, 2016 Valeritas Holdings, ... an alternative public offering (APO). This was accomplished via ... Valeritas, Inc. and a private placement of approximately 5 ... per share. Under the terms of the ... Valeritas Holdings, Inc. will trade on the OTC Markets ...
(Date:5/4/2016)... 2016 Research and ... Acute lymphocytic Leukemia Market and Competitive Landscape ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Market and Competitive Landscape Highlights 2016, provides ... products, Acute Lymphocytic Leukemia epidemiology, Acute Lymphocytic ...
(Date:5/3/2016)... 2016  As a teenager, an active and athletic ... damaged his heart. He continued enjoying sports and recreation ... Shepherd,s heart was giving out and he was a ... 2013, the Mesa, Arizona resident ... a heart transplant, the SynCardia TAH-t is the only ...
Breaking Medicine Technology: