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Autoantibodies and neuropsychiatric events in lupus
Date:2/27/2008

Medicine at Dalhousie University in Halifax, Nova Scotia, and supported in part by grants from the Canadian Institutes of Health Research and the Lupus Foundation of America, the study focused on 412 SLE patients recruited from 18 treatment centers. Over 87 percent of the subjects were women, ranging in age from 34 to 58 and representing diverse ethnic backgrounds -- Hispanic, Asian, black, and white. At the time of enrollment, the mean disease duration was only 5 months. Patients were evaluated to identify features of 19 NP syndromes, based on the American College of Rheumatology case definitions, within a 21-month window around the time of SLE diagnosis. Grouped into central and peripheral nervous system syndromes for analysis, the NP events included headaches, mood disorders, anxiety disorder, cerebrovascular disease, cognitive dysfunction, seizure disorder, acute confusional state, aseptic meningitis, movement disorder, Guillian-Barr syndrome, and psychosis. To determine the presence of telltale lupus autoantibodies, blood and plasma samples from each subject were analyzed in the research laboratory of Dr. Joan Merrill, a Rheumatologist and Chief of the Department of Clinical Pharmacology at the Oklahoma Medical Research Foundation and a co-investigator in the study.

Within the study window, 133 of the 412 patients (32.3 percent) had at least one NP event and 47 (11.4 percent) had two or more events. In total, the events encompassed 14 of the 19 recognized NP syndromes. The proportion of NP events directly attributed to SLE varied from 15 percent (32 of 214) to 36 percent (77 of 214), depending on the attribution model used. Testing for autoantibodies uncovered an association between anti-ribosomal P antibodies and psychosis. Seven patients had psychosis that was attributed to SLE and nearly half of these patients had anti-P antibodies. In addition, the presence of another lupus antibody called lupus anticoagulant was linked to cerebrovascul
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Contact: Amy Molnar
amolnar@wiley.com
Wiley-Blackwell
Source:Eurekalert

Page: 1 2 3

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