Navigation Links
Autism changes molecular structure of the brain, UCLA study finds
Date:5/25/2011

For decades, autism researchers have faced a baffling riddle: how to unravel a disorder that leaves no known physical trace as it develops in the brain.

Now a UCLA study is the first to reveal how the disorder makes its mark at the molecular level, resulting in an autistic brain that differs dramatically in structure from a healthy one. Published May 25 in the advance online edition of Nature, the findings provide new insight into how genes and proteins go awry in autism to alter the mind.

The discovery also identifies a new line of attack for researchers, who currently face a vast array of potential fronts for tackling the neurological disease and identifying its diverse causes.

"If you randomly pick 20 people with autism, the cause of each person's disease will be unique," said principal investigator Dr. Daniel Geschwind, the Gordon and Virginia MacDonald Distinguished Chair in Human Genetics and a professor of neurology and psychiatry at the David Geffen School of Medicine at UCLA. "Yet when we examined how genes and proteins interact in autistic people's brains, we saw well-defined shared patterns. This common thread could hold the key to pinpointing the disorder's origins."

The research team, led by Geschwind, included scientists from the University of Toronto and King's College London. They compared brain tissue samples obtained after death from 19 autism patients and 17 healthy volunteers. After profiling three brain areas previously linked to autism, the group zeroed in on the cerebral cortex, the most evolved part of the human brain.

The researchers focused on gene expression how a gene's DNA sequence is copied into RNA, which directs the synthesis of cellular molecules called proteins. Each protein is assigned a specific task by the gene to perform in the cell.

By measuring gene-expression levels in the cerebral cortex, the team uncovered consistent differences in how genes in a
'/>"/>

Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. U.S. Rates of Autism, ADHD Continue to Rise: Report
2. Validating preschool programs for children with autism
3. Massachusetts Study Shows Sharp Rise in Early Autism Diagnoses
4. Sporadic mutations identified in children with autism spectrum disorders
5. Fever During Pregnancy, Diabetes and Obesity May Raise Autism Risk
6. Autism Takes an Economic Toll on Moms Job, Income: Study
7. Teen Boys With Autism at Risk of Being Bullied: Study
8. S. Korean Study Suggests Autism Rate May Be Much Higher
9. Winter Conception Tied to Raised Risk for Autism
10. Prevalence of autism in South Korea estimated at 1 in 38 children
11. New study reveals autism prevalence in South Korea estimated to be 2.6 percent or 1 in 38 children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... Early surgery may not be the ... joint injuries, according to new research from Tripler Army ... Orthopaedic Society for Sports Medicine’s ( AOSSM ) Specialty ... surgery was not performed. , The final study group ... and 17 receiving non-surgical therapy. Of the non-surgery group, ...
(Date:3/28/2015)... La Mirada, CA (PRWEB) March 28, 2015 ... with ear, nose and throat disorders, are ... Tinnitus is a common issue which is characterized by ... ears. Affecting 1 in 5 people, tinnitus is a ... or disorder and while it is non-fatal, tinnitus can ...
(Date:3/28/2015)... 2015 Servpro of Paso Robles ... released a report about the link between mold and ... and according to recent medical research, may even cause ... the Environmental Protection Agency, people with sensitivity to mold ... mold may trigger asthma attacks for asthma sufferers. The ...
(Date:3/27/2015)... Florida Hospital is excited to continue its partnership with the ... for the 2015 and 2016 season. As the Storm’s exclusive ... athletic trainer for the team throughout each season. Tonight, the ... Cleveland Gladiators at Amalie Arena; the game starts at 7:30pm. ... as it gives us the opportunity, to provide health and ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 Healthpointe is ... G. Katz, M.D., is now treating knee and hip ... Anaheim , Long Beach, and La Mirada. Dr. ... acute knee and hip joint disorders as well as ... is passionate in returning his patients back to their ...
Breaking Medicine News(10 mins):Health News:For Type V AC Joint Injuries, Early Surgery May Not Be the Best Approach 2Health News:Healthpointe now Offering Tinnitus Treatments in Clinics throughout Southern California 2Health News:Water Damage Restoration Specialists Servpro of Paso Robles Release Report on Mold and Asthma 2Health News:Water Damage Restoration Specialists Servpro of Paso Robles Release Report on Mold and Asthma 3Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:Fellowship-Trained and Board-Certified Orthopedic Surgeon is Now Treating Knee and Hip Joint Disorders in Anaheim, California 2Health News:Fellowship-Trained and Board-Certified Orthopedic Surgeon is Now Treating Knee and Hip Joint Disorders in Anaheim, California 3
... , ... ... ... ...
... Farmers, markets are not created equal. Some sell only ... of vendors. And each market,s unique personality attracts some people ... based on what they offer, farmers, markets self-select people who ... stores isn,t one of them. "Not one of the ...
... ... ... ... ...
... ... ... ... ...
... ... ... , , ... ...
... ... ... , ... , , , ...
Cached Medicine News:Health News:Health Groups Ask Supreme Court to Authorize Financial Penalties on Tobacco Companies for Decades of Wrongdoing 2Health News:Health Groups Ask Supreme Court to Authorize Financial Penalties on Tobacco Companies for Decades of Wrongdoing 3Health News:Farmers' markets offer different strokes for different folks 2Health News:Farmers' markets offer different strokes for different folks 3Health News:Census Bureau News -- 2007 Economic Census: Health Care and Social Assistance Geographic Area Series (NAICS 62) 2Health News:Abbott Announces 10 Percent Increase in Quarterly Dividend 2Health News:Abbott Announces 10 Percent Increase in Quarterly Dividend 3Health News:Massachusetts Hospital Agrees to Pay U.S. $2.79 Million to Resolve False Claims Act Allegations 2Health News:With Record Registration of 13,000 Runners to Date, the 2010 Dick's Sporting Goods Pittsburgh Marathon Announces a Cap of 16,000 2Health News:With Record Registration of 13,000 Runners to Date, the 2010 Dick's Sporting Goods Pittsburgh Marathon Announces a Cap of 16,000 3
(Date:3/27/2015)... HILL, N.C. , March 27, 2015 ... is essential to meeting challenges in clinical development, market ... face tighter regulations, the Medical Affairs function is expected ... by mature markets. According to research ... study participants have a group dedicated to Medical Affairs. ...
(Date:3/27/2015)... March 27, 2015 /PRNewswire/ - Medicure Inc. (the "Company") ... has approved the grant of an aggregate of 236,070 ... and consultants of the Company pursuant to the Company,s ... to expire on the tenth anniversary of the date ... third anniversary of the date of grant and 50,000 ...
(Date:3/27/2015)... 27, 2015  Victoria Vein & Surgery Clinic is the ... Duality laser in Victoria, Texas . The ... as advanced laser treatments for a variety of medical and ... to provide more services for their patients. Since adding laser ... Victoria residents get rid of their unwanted ...
Breaking Medicine Technology:Medical Affairs Capabilities Expanding in Emerging Marketplaces 2Victoria Vein And Surgery Clinic Uses Advanced Astanza Duality Tattoo Removal Technology 2
... forward Juwan Howard and Basketball Hall of Famer Bob Lanier ... Health and Medicine (SAHM) today to bring Vaccines for ... is a national awareness campaign designed to educate teens ... and potentially life-threatening diseases. To tip off ...
... NEW YORK, Feb. 9, 2011 Reportlinker.com ... is available in its catalogue: ... Pharmaceutical applications by geography, technology trends and ... Report Description ...
Cached Medicine Technology:Miami HEAT Forward Juwan Howard and NBA Legend Bob Lanier Join Vaccines for Teens Educational Campaign to Urge Local Teens to Take Their Best Shot at Health 2Miami HEAT Forward Juwan Howard and NBA Legend Bob Lanier Join Vaccines for Teens Educational Campaign to Urge Local Teens to Take Their Best Shot at Health 3Miami HEAT Forward Juwan Howard and NBA Legend Bob Lanier Join Vaccines for Teens Educational Campaign to Urge Local Teens to Take Their Best Shot at Health 4Miami HEAT Forward Juwan Howard and NBA Legend Bob Lanier Join Vaccines for Teens Educational Campaign to Urge Local Teens to Take Their Best Shot at Health 5Reportlinker Adds Global Anti-counterfeit Markets in Food & Pharmaceutical Applications by Geography, Technology Trends and Forecasts (2010-2015) 2Reportlinker Adds Global Anti-counterfeit Markets in Food & Pharmaceutical Applications by Geography, Technology Trends and Forecasts (2010-2015) 3Reportlinker Adds Global Anti-counterfeit Markets in Food & Pharmaceutical Applications by Geography, Technology Trends and Forecasts (2010-2015) 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: