Navigation Links
Autism breakthrough: Researchers identify possible treatment for impaired sociability

NORFOLK, Va. Eastern Virginia Medical School researchers have identified a potential novel treatment strategy for the social impairment of people with Autism Spectrum Disorders (ASD), an aspect of the condition that has a profound impact on quality of life.

"Persons with Autism Spectrum Disorders are either disinterested in social interactions or find them unpleasant. They often don't understand what other people are thinking or feeling and misinterpret social cues," said Stephen I. Deutsch, MD, PhD, the Ann Robinson Chair and professor of psychiatry and behavioral sciences. "Sadly, persons with autism spectrum disorders are often painfully aware of their limited sociability, which can lead to profound feelings of sadness and frustration."

As part of their research, EVMS scientists verified that a specific mouse strain, known as the BALB/c mouse, is a valid animal model of the limited sociability seen in persons with ASD. In the presence of another mouse, BALB/c mice move as far away as possible and do not interact as normal mice do just like people with autism often avoid making social contact with other people.

This finding gave researchers a way to test whether an existing medication can alter the function of certain receptors in the brain known to affect sociability and help the animals be more at ease around others. The medication used, D-Cycloserine, originally was developed to treat tuberculosis, but previous studies showed, by chance, that it might change social behavior. In preliminary studies at EVMS, the medication appeared to resolve the Balb/c mouse's deficits of sociability; it behaved as a normal mouse would when placed near another.

Dr. Deutsch will discuss the research at EVMS' Quarterly Autism Education Series at noon, Dec. 14, in the school's Hofheimer Hall auditorium.

EVMS' laboratory studies with the Balb/c mouse led its investigators to hypothesize that D-Cycloserine could ease the impaired sociability of persons with autism, such as avoiding eye contact and personal interaction. Those traits can severely limit the possibility of employment and independent living for someone with autism.

"What makes this important is you might have someone with a 125 or 130 IQ who's unemployable" because of their social impairments, said Maria R. Urbano, MD, associate professor of psychiatry and behavioral sciences.

Dr. Urbano is moving this promising research from the laboratory directly to patient care by starting a pilot clinical trial of D-Cycloserine in adolescent and young adult patients with autism spectrum disorders. The trial will show whether the medication, which is already known to be safe for use in humans, has similar effects on the sociability deficits of persons with autism as it did in the mice. Her research is supported by a grant from the Hampton Roads Community Foundation.


Contact: Dan Shuman
Eastern Virginia Medical School

Related medicine news :

1. Toys"R"Us, Inc. Expands its Support of Autism Speaks Throughout North America
2. Local Carrollton Center Hosting More than 50 Autism Experts from Coast-to-Coast
3. Autism-Related Hypersensitivity Better Understood
4. Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders
5. Another Study Refutes Vaccination-Autism Link
6. Bonding Hormone Might Help Some With Autism
7. Autisms earliest symptoms not evident in children under 6 months
8. True Signs of Autism May Not Appear Until 1st Birthday
9. Court Orders Reinstatement of Vital, Cost-Saving Treatment for Children With Autism
10. Sumner Redstone Donates $1 Million to Autism Speaks to Support Autism Research and Programs
11. A mothers sensitivity may help language growth in children with autism spectrum disorder
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- VMS Rehab Systems, Inc. ( ) reported today ... to build a strong and stable market for trading ... the OTC Markets-pink current trading platform. Explains ... seeing an anomaly in market trading activities that may ... Company, but shareholders and market players as well. I ...
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
Breaking Medicine Technology: