Navigation Links
Autism breakthrough: Researchers identify possible treatment for impaired sociability
Date:12/8/2010

NORFOLK, Va. Eastern Virginia Medical School researchers have identified a potential novel treatment strategy for the social impairment of people with Autism Spectrum Disorders (ASD), an aspect of the condition that has a profound impact on quality of life.

"Persons with Autism Spectrum Disorders are either disinterested in social interactions or find them unpleasant. They often don't understand what other people are thinking or feeling and misinterpret social cues," said Stephen I. Deutsch, MD, PhD, the Ann Robinson Chair and professor of psychiatry and behavioral sciences. "Sadly, persons with autism spectrum disorders are often painfully aware of their limited sociability, which can lead to profound feelings of sadness and frustration."

As part of their research, EVMS scientists verified that a specific mouse strain, known as the BALB/c mouse, is a valid animal model of the limited sociability seen in persons with ASD. In the presence of another mouse, BALB/c mice move as far away as possible and do not interact as normal mice do just like people with autism often avoid making social contact with other people.

This finding gave researchers a way to test whether an existing medication can alter the function of certain receptors in the brain known to affect sociability and help the animals be more at ease around others. The medication used, D-Cycloserine, originally was developed to treat tuberculosis, but previous studies showed, by chance, that it might change social behavior. In preliminary studies at EVMS, the medication appeared to resolve the Balb/c mouse's deficits of sociability; it behaved as a normal mouse would when placed near another.

Dr. Deutsch will discuss the research at EVMS' Quarterly Autism Education Series at noon, Dec. 14, in the school's Hofheimer Hall auditorium.

EVMS' laboratory studies with the Balb/c mouse led its investigators to hypothesize that D-Cycloserine could ease the impaired sociability of persons with autism, such as avoiding eye contact and personal interaction. Those traits can severely limit the possibility of employment and independent living for someone with autism.

"What makes this important is you might have someone with a 125 or 130 IQ who's unemployable" because of their social impairments, said Maria R. Urbano, MD, associate professor of psychiatry and behavioral sciences.

Dr. Urbano is moving this promising research from the laboratory directly to patient care by starting a pilot clinical trial of D-Cycloserine in adolescent and young adult patients with autism spectrum disorders. The trial will show whether the medication, which is already known to be safe for use in humans, has similar effects on the sociability deficits of persons with autism as it did in the mice. Her research is supported by a grant from the Hampton Roads Community Foundation.


'/>"/>

Contact: Dan Shuman
shumandl@evms.edu
757-446-7070
Eastern Virginia Medical School
Source:Eurekalert

Related medicine news :

1. Toys"R"Us, Inc. Expands its Support of Autism Speaks Throughout North America
2. Local Carrollton Center Hosting More than 50 Autism Experts from Coast-to-Coast
3. Autism-Related Hypersensitivity Better Understood
4. Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders
5. Another Study Refutes Vaccination-Autism Link
6. Bonding Hormone Might Help Some With Autism
7. Autisms earliest symptoms not evident in children under 6 months
8. True Signs of Autism May Not Appear Until 1st Birthday
9. Court Orders Reinstatement of Vital, Cost-Saving Treatment for Children With Autism
10. Sumner Redstone Donates $1 Million to Autism Speaks to Support Autism Research and Programs
11. A mothers sensitivity may help language growth in children with autism spectrum disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... CA & CARMEL, IN (PRWEB) , ... August 18, 2017 , ... ... on its 36th annual list, the most prestigious ranking of the nation's fastest-growing private ... been included in the exclusive Inc. 5000 ranking . This year’s ranking reflects ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Three Narrow Roads”: a vivid and ... of published author, Rev. Dr. Burnett King Sr., is currently the pastor-teacher-visionary at Simply ... the Faith Track Club, Inc., a track-and-field program geared towards youth. , King shares, ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Kingdom Mandate for Kingdom Builders”: ... “Kingdom Mandate for Kingdom Builders” is the creation of published author, John F. ... Eastern Europe as a missionary in 1983. He spent three decades training pastors ...
(Date:8/17/2017)... ... August 17, 2017 , ... Riccobene Associates ... location in Goldsboro, NC to its family of practices. Residents of Goldsboro will ... starting August 15, 2017. , Riccobene Associates Family Dentistry, founded by Dr. ...
(Date:8/17/2017)... MA (PRWEB) , ... August 17, 2017 , ... ... will come together on September 19, 2017 for Anti-Infectives Rx. This off-the-record networking ... B. Martin Conference Center at Harvard Medical School. , Industry leaders and decision ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 7, 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... that its Board of Directors has approved the payment of ... of 2017. The cash ... about October 27, 2017 to stockholders of record as of ... of dividends are subject to approval of the Board of ...
(Date:8/4/2017)... -- Agragen, LLC, a Cincinnati -based ... and aquacultural feed sectors, announces a significant step ... AGR131.  This drug is designed to trap and ... patients suffering from inflammatory conditions such as rheumatoid ... Biological pharmaceuticals currently used ...
(Date:8/2/2017)... , Aug. 2, 2017 CaryRx, a next-generation full-service ... delivery service for patients in the Washington D.C. ... retail pharmacy by providing delivery of medications through the convenience ... future delivery or delivered within one hour to any location ... excited to bring this invaluable service to Washington ...
Breaking Medicine Technology: