Navigation Links
Autism Speaks trailblazer study -- Blocking cell distress signals can ease autism symptoms
Date:3/14/2013

tochondria are best known for providing cells with energy. Dr. Naviaux looked beyond energy production to study the mitochondria's role in signaling when a cell is damaged or diseased. Under stress, cells release mitochondrial, or "purinergic," chemicals that normally remain inside the cell. When they leak outside a cell, these chemicals signal danger to surrounding cells.

"In essence, these signals warn other cells to harden their defenses," Dr. Naviaux explains. "This helps protect against cell-to-cell infection. However, it may also interfere with cell-to-cell communication."

Normally, healthy cells stop releasing these danger signals when an infection or other stress resolves. According to Dr. Naviaux's "cell danger response" theory, autism can result when a stress during early brain development triggers a chronic danger response. The stress that starts this chain of events can come from an environmental influence, a genetic problem or a combination of both, he proposes. The result is chronic brain inflammation and frayed connections between brain cells. "When the brain cells stop talking, so do children," he says.

Dr. Naviaux's team produced litters of mice that exhibited autism symptoms by mimicking a viral infection in their mothers during pregnancy. This "maternal immune activation mouse model" is well-known for producing mouse offspring with symptoms of autism and schizophrenia.

The researchers measured social behavior by giving the mice opportunities to spend time with either another mouse or a Lego block in adjacent wire chambers. They also tested motor coordination as the mice walked along a rotating rod. While female pups showed only mild impairments, the male pups showed a 50 percent reduction in socializing and a 28 percent reduction in motor coordination. The researchers then tested the male pups' response to treatment. When the mice were 6 weeks old (roughly adolescents), 84 received an injection of suramin, a ch
'/>"/>

Contact: Jane E. Rubinstein
jrubinstein@rubenstein.com
212-843-8287
Autism Speaks
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Bradley Hospital researchers find age-related changes in how autism affects the brain
2. Trump Steps Up to Support Els for Autism
3. Most Kids With Autism Overcome Language Delays, Study Finds
4. Shared Genes May Link ADHD, Autism and Depression
5. Animals May Boost Social Interaction in Kids With Autism
6. Network analysis of the brain may explain features of autism
7. Brain Connections Differ in Children With Autism
8. Can Therapy Dogs Help Kids With Autism?
9. Higher levels of several toxic metals found in children with autism
10. Cleveland Clinic researcher receives grant to fund autism research
11. Researchers Detect an Anti-Autism Advantage in Females
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Autism Speaks trailblazer study -- Blocking cell distress signals can ease autism symptoms
(Date:6/2/2015)... (PRWEB) June 02, 2015 Highly qualified dental ... a plan to drive prolific change in the dental tourism ... TDC Team Dental Clinic offers a full range of ... management structure for dental tourism. , Partnered with a ... is committed to advancing dentistry and has earned a reputation ...
(Date:6/2/2015)... UCLA Health and Exer have completed ... and expand urgent care services in Los Angeles County. ... University of California Board of Regents and the Exer ... Health to purchase a minority share of four existing ... Park and Northridge and creates opportunity to grow and ...
(Date:6/2/2015)... Gujarat, India (PRWEB) June 02, 2015 ... finalist in the 2015 Microsoft Worldwide Small and Midsized ... global field of top Microsoft partners for demonstrating excellence ... Microsoft technology. , “This comes as no surprise ... are recognized third year consecutively at worldwide level by ...
(Date:6/2/2015)... TX, USA (PRWEB) June 02, 2015 ... microsystems, is deploying its growth strategy to benefit from ... BioMEMS: “In Yole Développement’s May 2015 Status of the ... will grow sharply and reach $6.6B in 2020,” says ... Yole Développement . , The analyst adds that ...
(Date:6/2/2015)... MI (PRWEB) June 02, 2015 Erbelli’s ... new website to promote its handmade gourmet pizzas and ... even though the website is new, the recipes are ... since 1995. The main feature of the site is ... appetizing pictures and descriptions of all the items. You ...
Breaking Medicine News(10 mins):Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 2Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 3Health News:UCLA Health Partners With Exer - More Than Urgent Care 2Health News:Bitscape Infotech recognized as finalist for 2015 Microsoft Worldwide small & midsized cloud solutions award. 2Health News:Bitscape Infotech recognized as finalist for 2015 Microsoft Worldwide small & midsized cloud solutions award. 3Health News:Tronics Aims to Benefit from Major Growth of Sensors and Related Technologies for Healthcare Applications 2Health News:Erbelli’s of Bradenton Launches New Mobile-Friendly Website 2
... 4 million men in the United States have low ... include erectile dysfunction, reduced muscle mass, reduced bone density, ... to increase testosterone levels for men with the condition. ... gel, or tablet. New research shows testosterone replacement therapy ...
... of osteoporosis. Such a break can lead to acute and ... to a recent study , it was found that the ... effective in reducing the risk for a vertebral fracture, according ... can reduce the risk of breaking a bone in the ...
... migraine headaches may be at risk for brain // lesions ... tissue has died. ,Researchers studied nearly 400 randomly ... into categories of having migraines with visual difficulties and having ... included in the study. Participants had a brain magnetic resonance ...
... shows only 7 percent of diabetics take the ... blood vessel problems. Researchers stressed continued negligence by ... retinopathy, neuropathy, nephropathy, coronary heart disease, stroke, and ... adults, ages 20 years or older, who had ...
... risk factors for melanoma skin cancer.// Previous research also shows ... detected early. ,New research shows patients who use photographs ... keep better track of new or changed moles. Researchers in ... atypical nevi, or pigmented moles that may change shape or ...
... age a person develops asthma may help explain their disease ... with asthma as children // have a different disease than ... patients suffered different symptoms and disease progression based on the ... that could not be controlled by steroids participated in the ...
Cached Medicine News:Health News:Onset Linked To Severity of Asthma 2
(Date:6/2/2015)... 2015 Stoltenberg Consulting , a ... announced the celebration of its 20-year anniversary and ... since its inception in 1995. ... the healthcare technology industry continues, we strive to ... to facilitating clients, organizational goals, understanding that today,s ...
(Date:6/2/2015)... their reach nationally by providing customers with on-site 17025 accredited pipette calibrations. ... ... ... ... Photo - http://photos.prnewswire.com/prnh/20150601/219758 As an industry-leading ...
(Date:6/2/2015)...  Ashion™ Advanced Individual Medicine™ (AIM), a ... industry, announced today the launch of its ... Medicine Platform. AIM develops and manages comprehensive ... healthcare systems, providing these centers with clinical ... operational support. AIM will use Syapse,s precision ...
Breaking Medicine Technology:Stoltenberg Consulting celebrates 20 years of healthcare IT consulting service 2Stoltenberg Consulting celebrates 20 years of healthcare IT consulting service 3Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 2Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 3Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 4Ashion Advanced Individual Medicine Chooses Syapse to Enable Genomics-Based Cancer Care in the Community 2Ashion Advanced Individual Medicine Chooses Syapse to Enable Genomics-Based Cancer Care in the Community 3
... Services Holdings Limited (the "Company" or "Concord Medical") (NYSE: ... of radiotherapy and diagnostic imaging centers in China, today ... of shareholders held in Beijing on November 26, 2011. ... "THAT Article 82(a) of the Articles of Association of ...
... -- Global Information, Inc. presents " Polycystic Ovarian ... to 2018 "  by GlobalData. (Photo:  ... a common chronic disorder of the endocrine system in ... years old) and is thought to be one of ...
Cached Medicine Technology:Concord Medical Announces Shareholder Resolutions Adopted at 2011 Annual General Meeting, Board and Management Changes 2Concord Medical Announces Shareholder Resolutions Adopted at 2011 Annual General Meeting, Board and Management Changes 3Concord Medical Announces Shareholder Resolutions Adopted at 2011 Annual General Meeting, Board and Management Changes 4Concord Medical Announces Shareholder Resolutions Adopted at 2011 Annual General Meeting, Board and Management Changes 5Concord Medical Announces Shareholder Resolutions Adopted at 2011 Annual General Meeting, Board and Management Changes 6GiiResearch.com: Polycystic Ovarian Syndrome (PCOS) Therapeutics - Market to Witness Static Growth Until 2018 2GiiResearch.com: Polycystic Ovarian Syndrome (PCOS) Therapeutics - Market to Witness Static Growth Until 2018 3
Standard 20x long working distance objectives for greater magnifications of your microtools....
... An economical laboratory tissue culture microscope, the ... expand their applications. Olympus has taken the ... CKX41. Fluorescence can be used with an ... can be carried out on the CKX41 ...
... Eclipse TE2000S is an advanced ... research. It's exclusive CFI60 optical ... high numerical aperatures and longer ... inverted microscope to take full ...
... new Eclipse TS-100 is an innovative ... high quality tool complements any research ... CFI60 optics offer brilliant, sharp ... superb optical performance with high resolution ...
Medicine Products: