Navigation Links
Australian researchers identify genes that cause melanoma
Date:7/6/2009

Scientists from the Queensland Institute of Medical Research (QIMR) have found two new genes that together double a person's risk of developing melanoma.

As part of an international study, a team at QIMR, led by Professors Nick Hayward and Grant Montgomery, studied the genes of almost 6,000 people together with their mole count. Specific changes in two genes were found to make people more susceptible to developing moles. The researchers went on to show, in another 4,000 people, the same two genes increased the risk of developing melanoma the most deadly form of skin cancer.

"These are the first genes found to increase melanoma risk by influencing the number of moles a person has," explained Professor Hayward. "This finding improves our understanding of the genetics of melanoma and therefore the molecular pathways that lead to its development."

"It has long been known that having a large number of moles is the biggest risk factor. Therefore we predicted we would find genes linking moles and melanoma. We now have conclusive genetic evidence that having a large number of moles increases an individual's risk of developing melanoma."

The study found that people who carry one of these two gene variants have a 25% increased chance of developing melanoma, while for individuals carrying both variants their risk is doubled.

"In the long term, this research will be useful in developing screening techniques, and will also allow us to identify potential new drug targets and ultimately develop new therapies to treat melanoma," said Professor Hayward.

Moles are normal but people should seek advice from their doctor if they observe any changes in size, colour or shape. People with lots of moles are at a higher risk of developing melanoma and should therefore take extra care to avoid overexposure to ultraviolet radiation.

Australia has the highest incidence of melanoma in the world with more than 10,000 new cases and 1000 people dying from the disease every year. Queensland has the highest incidence of any state with seven Queenslanders diagnosed with melanoma every day. More than one in 20 Queenslanders is expected to develop melanoma during their lifetime.


'/>"/>

Contact: Sarah Tennant
Sarah.Tennant@qimr.edu.au
61-733-620-291
Research Australia
Source:Eurekalert

Related medicine news :

1. Australian team reveals world-first discovery in a floppy baby syndrome
2. Australian clinical trials threatened: Jobs and patient access to new treatments at stake
3. MTF, Largest Tissue Bank, Provides Skin for Victims of Australian Wildfires
4. Cephalon Launches Takeover Offer for Australian Biotechnology Company, Arana Therapeutics
5. Frost & Sullivan: Australian Pharmaceuticals and Life Sciences IT Market Is Still Growing
6. ATS Medical Announces Australian Regulatory Approval for ATS 3f Aortic Bioprosthesis
7. Australian technology in global health toolkit
8. Mottram Honours His End of the HBA Great Australian Run challenge
9. HBA People Walk the Talk for Better Health in the HBA Great Australian Run
10. Indigenous Australian patients confused and frustrated by kidney disease
11. New Cosmetic Trends Change the Face of the Australian Botox Market
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... , ... May 05, 2016 , ... ... Drago presented a talk highlighting the organization’s successful Care Transitions program ... , The talk was titled “Minimizing Costs in the Post-Acute Environment Through Effective ...
(Date:5/5/2016)... CA (PRWEB) , ... May 05, 2016 , ... The ... the Year, Derek Pittman, along with his university coaching staff. Together they bring their ... with separate sessions run for youth players ages 5-13, and high school players. Session ...
(Date:5/5/2016)... (NEW YORK, New York) , ... (PRWEB) May 05, 2016 , ... ... partnership with healthcare talent acquisition startup, HireNurses, on the eve of National Nurses ... for job seeking nurses and healthcare employers. With their enrollment into the Talent Tech ...
(Date:5/5/2016)... ... 05, 2016 , ... United Collection Bureau, Inc. (UCB) announces Sarah Clark as ... years of experience within the healthcare revenue cycle industry. With a primary focus of ... Patient Financial Services at Spectrum Health. While at Spectrum Health, Clark helped Spectrum achieve ...
(Date:5/5/2016)... ... ... Institute will celebrate its three-year anniversary on May 14 by giving away a free ... May. To date, the Lung Institute has treated over 2,000 people at their five clinics ... the success of this treatment and to the patients who refuse to give up,” says ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Yissum Research Development Company ... that it had signed an exclusive world-wide licensing and ... novel protein degradation and immunomodulatory drugs for cancer and ... candidates representing first-in-class therapy for hematologic and solid malignancies. ... The novel technology was developed by Yinon ...
(Date:5/4/2016)... , May 4, 2016 ... of the  "Global Acute Ischemic Stroke Market ... to their offering.       (Logo: ... Global Acute Ischemic Stroke Market and Competitive ... Acute Ischemic Stroke pipeline products, Acute Ischemic ...
(Date:5/3/2016)... Global Insulin Needles Industry ... key companies and supported with 272 tables and ... on the current state of the Insulin Needles ... including definitions, classifications, applications and industry chain structure. ... the international market including development history, competitive landscape ...
Breaking Medicine Technology: