Navigation Links
Australian researchers identify genes that cause melanoma
Date:7/6/2009

Scientists from the Queensland Institute of Medical Research (QIMR) have found two new genes that together double a person's risk of developing melanoma.

As part of an international study, a team at QIMR, led by Professors Nick Hayward and Grant Montgomery, studied the genes of almost 6,000 people together with their mole count. Specific changes in two genes were found to make people more susceptible to developing moles. The researchers went on to show, in another 4,000 people, the same two genes increased the risk of developing melanoma the most deadly form of skin cancer.

"These are the first genes found to increase melanoma risk by influencing the number of moles a person has," explained Professor Hayward. "This finding improves our understanding of the genetics of melanoma and therefore the molecular pathways that lead to its development."

"It has long been known that having a large number of moles is the biggest risk factor. Therefore we predicted we would find genes linking moles and melanoma. We now have conclusive genetic evidence that having a large number of moles increases an individual's risk of developing melanoma."

The study found that people who carry one of these two gene variants have a 25% increased chance of developing melanoma, while for individuals carrying both variants their risk is doubled.

"In the long term, this research will be useful in developing screening techniques, and will also allow us to identify potential new drug targets and ultimately develop new therapies to treat melanoma," said Professor Hayward.

Moles are normal but people should seek advice from their doctor if they observe any changes in size, colour or shape. People with lots of moles are at a higher risk of developing melanoma and should therefore take extra care to avoid overexposure to ultraviolet radiation.

Australia has the highest incidence of melanoma in the world with more than 10,000 new cases and 1000 people dying from the disease every year. Queensland has the highest incidence of any state with seven Queenslanders diagnosed with melanoma every day. More than one in 20 Queenslanders is expected to develop melanoma during their lifetime.


'/>"/>

Contact: Sarah Tennant
Sarah.Tennant@qimr.edu.au
61-733-620-291
Research Australia
Source:Eurekalert

Related medicine news :

1. Australian team reveals world-first discovery in a floppy baby syndrome
2. Australian clinical trials threatened: Jobs and patient access to new treatments at stake
3. MTF, Largest Tissue Bank, Provides Skin for Victims of Australian Wildfires
4. Cephalon Launches Takeover Offer for Australian Biotechnology Company, Arana Therapeutics
5. Frost & Sullivan: Australian Pharmaceuticals and Life Sciences IT Market Is Still Growing
6. ATS Medical Announces Australian Regulatory Approval for ATS 3f Aortic Bioprosthesis
7. Australian technology in global health toolkit
8. Mottram Honours His End of the HBA Great Australian Run challenge
9. HBA People Walk the Talk for Better Health in the HBA Great Australian Run
10. Indigenous Australian patients confused and frustrated by kidney disease
11. New Cosmetic Trends Change the Face of the Australian Botox Market
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Becker’s Spine Review, the leading ... Michigan neurosurgeon Jay Jagannathan, M.D., as a “Spine Surgeon to Know.” http://www.beckersspine.com/spine-leaders/item/35348- ... in Michigan performing minimally invasive back surgery that often results in less post-operative ...
(Date:2/22/2017)... ... February 22, 2017 , ... Forty-five percent of ... report that family members or friends have also commented about their poor hearing. ... wear hearing aids. One reason, suggested by 89 percent of American respondents, is ...
(Date:2/22/2017)... ... ... Social media marketing is transitioning from a singular person activity to a collaborative ... this insight and more in its latest episode of its Brains Over Brawn podcast. ... social media strategist and partner of the digital firm Med|Ed Digital Jessica Columbo. Jessica ...
(Date:2/22/2017)... ... February 22, 2017 , ... In ... advocates stress that the patient context (age, illness and life choices) should be ... mitigate their occurrence. In addition, all too often, studies regarding health ...
(Date:2/21/2017)... Australia (PRWEB) , ... February 22, 2017 , ... Author ... it is valuable for every household and family to know all about it for ... publishing world with the release of “ Detox, Digestive and Wellness Solutions ” (published ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... and HAMBURG, Germany , February 22, 2017 ... precision oncology headquartered in Hamburg, Germany and ... research institution, announced today a collaboration to support the first Indian ... research. ... Indivumed signed an agreement with an initial three-year term. The collaboration ...
(Date:2/22/2017)... , Feb. 22, 2017  Soligenix, Inc. (Nasdaq: ... a late-stage biopharmaceutical company focused on developing and ... is an unmet medical need, announced today that ... granted a European patent for the treatment of ... methods of treatment of skin conditions, complements the ...
(Date:2/21/2017)... Feb. 21, 2017 Mass Spectrometer Market: ... http://www.reportlinker.com/p04711309-summary/view-report.html This report on mass ... future prospects of the market globally. The stakeholders ... in the manufacture and commercialization of various mass ... entrants planning to enter this market. This report ...
Breaking Medicine Technology: