Navigation Links
Australian researchers identify a new disease
Date:5/17/2010

Researchers at the Queensland Institute of Medical Research (QIMR) and the Royal Brisbane Women's Hospital have identified a previously undiagnosed condition and successfully treated it by performing an experimental stem cell transplant.

Having spent her late teenage years in and out of hospital Katie Pulling had almost given up hope. "It was very confusing and very daunting. I kept hearing the doctors say, 'We don't know what is wrong', 'We don't know why you are so sick'," said Katie, who lives in north-eastern NSW.

With no options left Katie agreed to an experimental stem cell transplant a transplant which ultimately saved her life.

"Katie presented with a range of symptoms when she was eleven. No one could identify her condition and no treatment had been successful. She did not respond to regular treatments and she continued to get sick, often complicated by life-threatening infections," said Dr Maher Gandhi head of QIMR's Clinical Immunohaemotology Laboratory.

The key to unlocking the reason for Katie's reoccurring symptoms came when she contracted the common teenage virus that causes glandular fever. Usually most people come down with only a mild infection. However, Katie developed a full-blown version known as fulminant infectious mononucleosis (FIM).

"This is an incredibly rare, life threatening disorder characterised by fever, a massive spleen and destruction of the patient's blood cells. We realised the FIM was linked to her other reoccurring medical problems. The signals in Katie's immune system were not functioning normally. This meant her immune cells could not communicate with each other properly," said Dr Gandhi.

The only treatment was to replace her immune system.

"We contacted Dr Glen Kennedy, an expert in bone marrow stem cell transplantation at the Royal Brisbane Hospital, to see if this might offer a cure."

"The transplant was dangerous, but the results were amazing. The defect in Katie's immune cells has been fixed. To our knowledge this is the first time this disorder has been reported. We hope this will help anyone who has presented with the same symptoms and had no success with treatments," said Dr Maher Gandhi.

"Now I don't get sick. I am really not used to it and keep waiting to get sick. I am now back to full time study and loving it," said Katie, now 23 and completing a Bachelor of Business.

"I would like to thank the researchers for letting me know I was not completely alone in this fight and for shedding light on the reason for my illness. They devoted so much time and energy so I can live a normal life."

QIMR's Clinical Immunohaematology Laboratory is funded by the NHMRC, the Leukaemia Foundation of Queensland, Cancer Council of Queensland and the Queensland Smart State initiative.

The results were published in March in Clinical Infectious Diseases.


'/>"/>

Contact: Sarah Tennant
Sarah.Tennant@qimr.edu.au
61-733-620-291
Research Australia
Source:Eurekalert

Related medicine news :

1. Global Financial Innovations Conference Chooses Australian Start Up, Controlabill
2. Australian Open Winner Serena Williams Trains With Power Plate(R) Equipment
3. 2/3 of Australians unlikely to get vaccinated against swine flu
4. Researchers define traits associated with prescription drug disorders in a primary care setting
5. Researchers demonstrate that safe cigarettes are as hazardous as tobacco
6. Level of frailty predicts surgical outcomes in older patients, Johns Hopkins researchers find
7. Researchers discover new way to rescue treatment sensitivity of breast cancer cells
8. Mild-mannered metabolic helper rushes to fight invading viruses, researchers report
9. UT Southwestern researchers uncover Fragile X syndrome genes role in shaping brain
10. U of T researchers crack splicing code, solve a mystery underlying biological complexity
11. PMH cancer researchers link ovarian hormone to breast stem cells growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2017)... ... September 20, 2017 , ... In just a short time ... already been receiving positive feedback from customers trying the product for the first time, ... Brain Booster was developed by neurosurgeon Shawn Moore, MD, for everyone from athletes at ...
(Date:9/20/2017)... ... September 20, 2017 , ... The Centers for Medicare and ... that it will transition to using only Worksheet S-10 to distribute Disproportionate Share Hospital ... three live 60-minute complimentary webinars on October 17, 2017 at 2 P.M. ...
(Date:9/20/2017)... ... September 20, 2017 , ... Recognising that in today’s busy ... Greeny delivers positive results in just three weeks. Setting the groundwork for a ... Fitting seamlessly into hectic work and family schedules, participants can lose up to ...
(Date:9/20/2017)... ... , ... “Finn Mouseson”: follows the exciting story of a mouse as the ... out on a journey that will show that friends are to be gathered but ... author and illustrator, Melody Gersonde-Mickelson, who has earned a bachelor’s degree in Fine Arts ...
(Date:9/20/2017)... , ... September 20, 2017 , ... “Psalms of Humidity”: ... peace of mind and move the readers one step closer to God. “Psalms of ... realized that his mistakes that have been made within his life are the very ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... 18, 2017 EpiVax, Inc. ("EpiVax") ... and immune engineering, today announced a new ... (H7N9) vaccine. ... influenza and presents a challenge for traditional ... to be effective. Using state-of-the-art bioinformatics and molecular ...
(Date:9/12/2017)... YORK , Sept. 12, 2017   EcoVadis , the leading ... has published the first annual edition of its Global CSR Risk and ... companies evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 ... ... Index ...
(Date:9/12/2017)... 12, 2017  ValGenesis Inc., the global leader ... pleased to announce the appointment of Dr. ... Board of Directors and Chairman of Advisory Board ... science companies to manage their entire validation lifecycle ... in this process. Furthermore, ValGenesis VLMS enables rigorous ...
Breaking Medicine Technology: