Navigation Links
Aurora-A hinders tumor-suppressor to allow chemotherapy resistance
Date:2/27/2012

oses its ability to bind to DNA and to transactivate its target genes
  • p73 gets locked outside the nucleus in the cell's cytoplasm.

    The researchers found lung cancer cells overexpressing Aurora-A have p73 evenly distributed in the nucleus and cytoplasm, but when treated with an Aurora-A inhibitor, p73 is found mainly in the nucleus. They repeated this experiment with similar results in breast and pancreatic cancer cell lines in which Aurora-A is overexpressed.

    Mortalin ties phosphorylated p73 in cytoplasm

    Sen and colleagues found that the protein mortalin binds to p73 that's been phosphorylated by Aurora-A, and plays a role moving p73 out to the cytoplasm and keeping it there. Mortalin has been implicated in tumor formation and immortalization.

    In addition to DNA damage, p73 also regulates the mitotic spindle assembly checkpoint, which regulates a specific mechanism involved in the normal separation of chromosomes during cell division. The team found that Aurora-A phosphorylation of p73 also inactivates this checkpoint function.

    They also found Aurora-A expressed at normal levels has a regular role to play in phosphorylating p73 in normal spindle assembly checkpoint function during cell division.

    Aurora-A effect on p73 found in human pancreatic cancer

    When they treated lung cancer cells with cisplatin, cells with phosphorylated p73 were least sensitive to cell death caused by the chemotherapy. In the absence of Aurora-A overexpression, cells were more sensitive to cisplatin treatment.

    The team analyzed p73 and Aurora-A in 114 samples of human pancreatic ductal adenocarcinoma at MD Anderson and found 51 (44.7 percent) had high Aurora-A expression and 37 of those had high levels of p73 in the cytoplasm. Of the 63 low-Aurora-A tumors, only 18 (28.6 percent) had high levels of p73 in the cytoplasm.

    Inactivation of the DNA and spindle damage-induced cell death pathways ma
    '/>"/>


  • Contact: Scott Merville
    smerville@mdanderson.org
    713-792-0661
    University of Texas M. D. Anderson Cancer Center
    Source:Eurekalert

    Page: 1 2 3

    Related medicine news :

    1. More Evidence That Alcohol Hinders Good Sleep
    2. Patient personality hinders detection of depression
    3. First analysis of tumor-suppressor interactions with whole genome in normal human cells
    4. Researchers discover second protective role for tumor-suppressor
    5. Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapy
    6. NOAA scientists: spilled oil unexpectedly lethal to fish embryos in shallow, sunlit waters
    7. Study explores mens ability to manage fear in ways that allow them to exhibit confidence
    8. Are doing harm and allowing harm equivalent? Ask fMRI
    9. Experts Offer Lucky 13 Tips for Safe and Healthy Halloween
    10. Halloween Doesnt Have to be Scary for Your Diet
    11. Healthy Halloween Advice for Children With Diabetes
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:5/28/2015)... Scotch Plains, NJ (PRWEB) May 28, 2015 ... Dr. Farhad Rafizadeh, specializes in delivering world-class results. ... of Plastic Surgery and a background in art, Dr. ... look. His unique approach to Plastic Surgery involves ... addition, his practice delivers a superior level of comfort ...
    (Date:5/28/2015)... As the summer approaches, many people will head ... to make safety a top priority, however, and that’s why ... According to the Centers for Disease Control, 10 people die ... boating incidents. Additionally, the National Safety Council says drowning is ... 4. , Amica is sharing the following tips from ...
    (Date:5/28/2015)... Trends Investing ” was featured on NewsWatch as part of ... medium, and large businesses making an impact in their industry. ... the business review and shared with viewers how this website ... money. , The idea, “let your money work for you” ... how to succeed are two different things. So if ...
    (Date:5/28/2015)... More than 300 locations of the ... to help the Muscular Dystrophy Association save and improve ... life-threatening diseases that limit muscle strength and mobility by ... From June 1 to June 30, sweetFrog associates will ... to help send local children affected by neuromuscular diseases ...
    (Date:5/28/2015)... BC (PRWEB) May 28, 2015 ... Research ( http://www.idataresearch.com ), the shoulder reconstruction device ... orthopedic small bone & joint market in 2014. ... shoulder arthroplasty procedures in the U.S. due to ... improved device technology resulting in greater patient outcomes. ...
    Breaking Medicine News(10 mins):Health News:"NJ Top Doc", Dr. Farhad Rafizadeh is Excited to Offer New Services at his Plastic Surgery Practice 2Health News:"NJ Top Doc", Dr. Farhad Rafizadeh is Excited to Offer New Services at his Plastic Surgery Practice 3Health News:Splash! Amica Shares 6 Swimming Safety Tips 2Health News:An Application to Learn Where to Invest Money was Featured on NewsWatch Television 2Health News:sweetFrog and MDA Join Forces to Send Kids with Muscle Disease to Summer Camp 2Health News:sweetFrog and MDA Join Forces to Send Kids with Muscle Disease to Summer Camp 3Health News:DePuy Synthes and Biomet Lead Fastest Growing U.S. Shoulder Reconstruction Device Market 2Health News:DePuy Synthes and Biomet Lead Fastest Growing U.S. Shoulder Reconstruction Device Market 3
    ... 21 (HealthDay News) -- No new patients will be ... controversial diabetes drug Avandia until further notice, the U.S. ... the partial clinical trial hold, those patients already enrolled ... trial will be allowed to continue to participate, the ...
    ... Hospitals Case Medical Center Center for AIDS Research ... renewal grant from the National Institutes of Health ... and technological support to researchers working on HIV-related ... Medical Center, MetroHealth Medical Center, Cleveland Clinic, and ...
    ... (HealthDay News) -- The cancer drug Avastin should no longer ... Food and Drug Administration advisory panel voted Tuesday, saying the ... represented a setback for Avastin, which is the world,s best-selling ... Avastin is sold by drug maker Roche,s Genentech unit, ...
    ... ,The Lancet Series on HIV in people ... at the International AIDS conference in Vienna, reports that ... injecting drug users (IDUs), health providers must focus less ... and more on conditions of health delivery that create ...
    ... Gay and bisexual men enrolled in a long-term study of ... experience psychosocial health problems later in life that could put ... Pittsburgh Graduate School of Public Health researchers at the ... more than 1,000 HIV-positive and negative gay and bisexual men ...
    ... By Kathleen Doheny HealthDay Reporter , TUESDAY, July ... older adults, meant to be humorous, shows a vulture on a ... might find the humor unsettling, the blunt message is right on ... is better than none, exercise experts say. Yet they also ...
    Cached Medicine News:Health News:FDA Puts Partial Hold on Avandia Safety Study 2Health News:$9M NIH grant renewal awarded to Case Western Reserve/UHCMC Center for AIDS Research 2Health News:$9M NIH grant renewal awarded to Case Western Reserve/UHCMC Center for AIDS Research 3Health News:FDA Advisers Say Avastin Shouldn't Be Used for Breast Cancer 2Health News:Improved treatment access requires end to portrayal of drug abusers as already dead 2Health News:Improved treatment access requires end to portrayal of drug abusers as already dead 3Health News:'Get Moving' Can Be Vital Advice for Seniors 2Health News:'Get Moving' Can Be Vital Advice for Seniors 3
    (Date:5/28/2015)... May 28, 2015 ... the addition of the  "North America Ultrasound ... (2014 - 2019)"  report to their offering.  ... Ultrasound is a type of imaging. It ... body parts and structures inside the body. ...
    (Date:5/28/2015)... SAN DIEGO , May 28, 2015 /PRNewswire/ ... a clinical-stage biopharmaceutical company leveraging its molecular adhesion ... therapies for sickle cell disease, heart failure, and ... be resigning from the Company,s Board of Directors. ... potential conflict of interest given his role as ...
    (Date:5/28/2015)... and CAMBRIDGE, Mass., May 28, 2015  Shareholder rights ... whether certain officers and directors of Eleven ... shareholders.  Eleven Biotherapeutics is a clinical-stage biopharmaceutical company ... protein therapeutics to treat eye diseases, primarily in ... View this press release on the ...
    Breaking Medicine Technology:North America Ultrasound Devices Market Report 2014-2019 - Technology and Applications 2Mast Therapeutics Announces Change In Board Of Directors 2Mast Therapeutics Announces Change In Board Of Directors 3Mast Therapeutics Announces Change In Board Of Directors 4Robbins Arroyo LLP Is Investigating the Officers and Directors of Eleven Biotherapeutics, Inc. (EBIO) on Behalf of Shareholders 2
    ... N.Y., Jan. 26, 2011 Crestwood Technology Group ... 2010 Boeing Performance Excellence Award. The Boeing Company ... have achieved superior performance. CTG maintained a Silver ... 12-month performance period, from Oct. 1, 2009, to ...
    ... flu can be very serious for everybody. So serious, in ... recently recommended that nearly everyone get a flu vaccine. This ... As people age, it becomes more difficult for them ... greater risk of serious flu-related complications, including pneumonia, hospitalization and ...
    Cached Medicine Technology:Crestwood Technology Group Receives Silver Boeing Performance Excellence Award 2Crestwood Technology Group Receives Silver Boeing Performance Excellence Award 3Blue Cross and Blue Shield of Georgia Urges Seniors to Get Flu and Pneumonia Vaccines 2Blue Cross and Blue Shield of Georgia Urges Seniors to Get Flu and Pneumonia Vaccines 3Blue Cross and Blue Shield of Georgia Urges Seniors to Get Flu and Pneumonia Vaccines 4
    Instrument for transphenoidal hypophysectomy, bayonet-shaped, dissector, sharp inner edge, left....
    Papavero-caspar specula for trans-sphenoidal hypophysectomy....
    ... Triad Facet Screws ... a posterior tension band ... construct. Through utility of ... percutaneous placement of Triad ...
    Cushing pituitary scoop, malleable, silver-plated....
    Medicine Products: