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AuCoin gets $600,000 to refine new test for deadly bacterial infection melioidosis
Date:8/8/2012

unoassay diagnostic, which is a dipstick test that can accept many patient sample types."

AuCoin produced and has been working with the monoclonal antibody used in the test since 2009. The work is also funded by the Pacific Southwest Regional Center for Excellence in Biodefense and Emerging Infections.

The STTR is a Phase I grant. The team is working to secure Phase II funding following the two years of Phase I work, which will allow another three years of product development to generate the necessary preclinical studies to submit an application to the FDA for approval to distribute the assay.

In addition to diagnosing a melioidosis infection, the lab has shown that it may be possible to treat patients with antibodies that bind to B. pseudomallei to prevent severe disease.

B. pseudomallei has been classified as a biothreat by the CDC due to its high mortality rate, low infectious dose and ability to be aerosolized. Melioidosis is difficult to treat and diagnose because B. pseudomallei is resistant to common antibiotics and symptoms are non-specific. Mortality rates reach 45 percent and 20 percent in Thailand and Australia respectively, even with antibiotic treatment.

AuCoin is a principal investigator within the Diagnostics Discovery Laboratory, which is a research group within the University of Nevada School of Medicine's Department of Microbiology and Immunology. The lateral flow immunoassay (LFI) he is developing is a similar process as another developed in the lab on the Reno campus by professor of microbiology and immunology Tom Kozel.

Kozel's LFI is a new point-of-care test to detect a cryptococcal antigen, and diagnose cryptococcal meningitis, a leading cause of death among AIDS patients in developing countries. The new rapid diagnostic has the potential to save hundreds of thousands of lives a year. Kozel and AuCoin are also collaborating on a diagnostic product for the early dete
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Contact: Mike Wolterbeek
mwolterbeek@unr.edu
University of Nevada, Reno
Source:Eurekalert  

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AuCoin gets $600,000 to refine new test for deadly bacterial infection melioidosis
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