Navigation Links
Atypical form of Alzheimer's disease may be present in a more widespread number of patients
Date:5/1/2014

in hippocampal sparing AD, although patients do not have vocal or hearing deficits.

"What is tragic is that these patients are commonly misdiagnosed and we have new evidence that suggests drugs now on the market for AD could work best in these hippocampal sparing patients possibly better than they work in the common form of the disease," Dr. Murray says.

The researchers benefit greatly from one of the largest brain banks in the country more than 6,500 brain donations as well as a collaborative environment between neuroscience research and neurology at Mayo Clinic, she says.

Both hallmark proteins of AD amyloid beta (Aβ), which forms Aβ plaques, and tau, which produces tangles are found across all subtypes of AD, including hippocampal sparing AD. The researchers developed a mathematical algorithm to classify AD subtypes using tangle counts. "What is fascinating is that all the AD patient subtypes had the same amount of amyloid, but for some reason tau tangles were found in strategic cortical regions disproportionate to the hippocampus."

In these patients, tau preferentially damages and eventually destroys neurons in parts of the brain involved in behavior, motor awareness and recognition, as well as use of speech and vision, Dr. Murray says.

She says she hopes this research, the second high-profile Mayo study to highlight hippocampal sparing AD, will "open the minds" of clinicians who are trying to diagnose dementia, helping them understand that loss of memory is not present in every AD patient.

"Our studies support the notion that dementia related to AD does not necessarily equate to a loss of memory, and points to the need for more research in amyloid and tau imaging biomarkers to help clinicians accurately diagnose AD regardless of subtype," Dr. Murray says.


'/>"/>

Contact: Kevin Punsky
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. TrueWholesaleJewelry.com Launches Atypical Consumer Direct Wholesale Jewelry Site
2. Immunoglobulins Market to 2019 - Demand in Primary Immunodeficiency And CIDP Potentially Supplemented by Approval for Alzheimers Disease Available at ResearchMoz.us
3. Indoor Memory Maker Triathlon Raises Funds for Alzheimers
4. Witnessing, Experiencing Traumatic Events May Worsen Heart Disease
5. Pulse pressure elevation could presage cerebrovascular disease in Alzheimers patients
6. Mayo Clinic offers newly approved treatment for acid reflux disease
7. Spouses of Cancer Patients May Have Raised Risk of Heart Disease, Stroke
8. Huntingtons Disease Linked to Reduced Cancer Risk in Study
9. AstraZeneca and DNDi to collaborate on drug screening for neglected tropical diseases
10. Role of Screening, Monitoring in Early Kidney Disease Unclear
11. No Proof That Gum Disease Causes Heart Disease, Experts Say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 30, 2014 Dynamic health trends, ... growth in the Bread Production industry over the ... to moderate their consumption of a variety of ... varieties shrunk the market for white loaf bread ... responded by introducing more nutritious products to attract ...
(Date:9/30/2014)... 30, 2014(BRONX, NY)Medications are the leading cause of allergy-related ... of death certificates from 1999 to 2010, conducted by ... Albert Einstein College of Medicine of Yeshiva University ... Journal of Allergy and Clinical Immunology , also found ... particularly high among older people and African-Americans and that ...
(Date:9/30/2014)... Fat Burning Kitchen , the latest diet ... Geary that is helping people learn the truth about so-called ... machine in less than 24 hours has caught the attention ... our culture that is becoming so obsessed with diets and ... really fact and fiction when it comes to health foods, ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 For most ... the apple orchard, pumpkin patch or annual festival. For ... fast-spreading viruses – like the respiratory infection Enterovirus D68. ... most children, a small percentage – especially children with ... Increased concern about the Enterovirus is prompting hospitals across ...
(Date:9/30/2014)... September 30, 2014 A group of Americans ... combat an epidemic that, left unchecked, could create a catastrophic, ... not headed to Africa. John Rogers, the Executive Director the ... Korea to fight a disease most think mankind conquered long ... 80 years ago is on the comeback in several countries ...
Breaking Medicine News(10 mins):Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Bread Production in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Comprehensive Study of allergic deaths in US finds medications are main culprit 2Health News:Fat Burning Kitchen: Review Exposes Mike Geary’s 24-Hour Diet Transformation for Helping the Body Burn Fat Through a Natural Diet 2Health News:Fat Burning Kitchen: Review Exposes Mike Geary’s 24-Hour Diet Transformation for Helping the Body Burn Fat Through a Natural Diet 3Health News:As Hospitals Combat Enterovirus Outbreaks, Patients and Families Turn to “Virtual Visits” with CaringBridge 2Health News:US Delegation Heads to North Korea to Combat Tuberculosis Epidemic 2
... ... biopsy techniques away from more invasive approaches toward imaging-guided percutaneous—or through the skin—techniques, according ... journal Radiology . , ... Oak Brook, IL (Vocus) June 29, 2010 -- Advanced imaging technologies ...
... By Amanda Gardner HealthDay Reporter , MONDAY, ... from several large clinical trials, the diabetes drug Avandia does ... argument that the drug,s risks might outweigh its benefits in ... however, show an increased risk for death from cardiovascular disease, ...
... HealthDay Reporter , MONDAY, June 28 (HealthDay News) -- ... drugs known as statins are a third less likely to ... that your doctor prescribe a statin -- drugs such ... The findings aren,t firm enough for doctors to make ...
... BROOK, Ill. Arthroscopic surgical repair of torn anterior cruciate ... not decrease the chances of developing osteoarthritis, according to a ... issue of the journal Radiology . A ... knee osteoarthritis was evident in patients, regardless of whether or ...
... children and teenagers for watching too much TV. It turns ... their time watching TV, and it is not good for ... Research on Aging and Rady School of Management at the ... a study published online in advance of publication in the ...
... review, led by Dr. Joseph Lee, published in the June 2010 ... Orthopaedic Surgeons ( JAAOS ) suggests that a herniated disk ... leg pain in adults, but surgery is not for everyone. ... pain at some point in their lives Disks, which are ...
Cached Medicine News:Health News:Use of Less Invasive, Imaging-Guided Biopsies on the Rise 2Health News:Use of Less Invasive, Imaging-Guided Biopsies on the Rise 3Health News:Diabetes Drug Avandia Ups Heart Risk, Reviews Conclude 2Health News:Diabetes Drug Avandia Ups Heart Risk, Reviews Conclude 3Health News:Diabetes Drug Avandia Ups Heart Risk, Reviews Conclude 4Health News:Statins May Lower Rates of Prostate Cancer Recurrence 2Health News:Surgical repair of knee injuries does not decrease risk of osteoarthritis 2Health News:Older adults watch more TV than younger people, enjoy it less 2Health News:Lower back pain and surgery 2
(Date:9/30/2014)... Sept. 30, 2014  Alimera Sciences, Inc. (NASDAQ: ... in the research, development and commercialization of prescription ophthalmic ... million advance from Hercules Technology Growth Capital, Inc. (NYSE: ... second and final advance under the Loan and Security ... Kingdom , Alimera Sciences Limited, entered into with ...
(Date:9/30/2014)... 2014 Valeant Pharmaceuticals International, Inc. (NYSE: ... the company,s Bridgewater, New Jersey ... and Drug Administration (FDA) relating to an inspection in ... Sculptra Aesthetic injectable, which was divested to Galderma S.A. ... of Valeant,s contract manufacturers (rather than Valeant,s own internal ...
(Date:9/30/2014)... Sept. 30, 2014  Based on its recent ... & Sullivan recognizes Ventana Medical Systems, Inc. (Ventana), ... 2014 North American Frost & Sullivan Award for ... along with a focus on innovation and improving ... in tissue-based cancer diagnostic solutions for patients worldwide. ...
Breaking Medicine Technology:Alimera Sciences Receives $25 Million Advance from Hercules Technology Growth Capital 2Valeant Pharmaceuticals' Bridgewater Location Receives Warning Letter From FDA 2Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 2Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 3Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 4
... launches integrated, multi-channel offerings for three fast-growing export sectors -- HONG KONG, Oct. 26 /PRNewswire-Asia/ -- ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; ... var shortURL = ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; ...
... Oct. 25 Stereotaxis, Inc. (Nasdaq: STXS ) announced ... quarter ended September 30, 2010, on Monday, November 1, ... will host a conference call and webcast on Monday, ... discuss the Company,s third quarter results and corporate developments. ...
Cached Medicine Technology:Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 2Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 3Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 4Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 5Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 6Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 7Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 8Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 9Stereotaxis Announces Third Quarter 2010 Earnings Release Date and Conference Call 2Stereotaxis Announces Third Quarter 2010 Earnings Release Date and Conference Call 3
... Two Large Working Channels; 33 cm Working ... is the smallest ureteroscope with two large ... The ACMI MICRO-6 Ureteroscope reduces patient trauma ... or no dilation or general anesthesia. It ...
Smooth, contoured visual obturator provides less traumatic insertion through the urethra and into the bladder....
Semi-Rigid Ureteroscope...
... features a tip diameter of only ... up/down angulation range of 180 for ... areas.,For improved observation, a new optical ... reusable 11.7Fr (3.9mm) sheath dilator, 0.035" ...
Medicine Products: