Navigation Links
Attacking bowel cancer on 2 fronts
Date:3/30/2011

Stem cells in the intestine, which when they mutate can lead to bowel cancers, might also be grown into transplant tissues to combat the effects of those same cancers, the UK National Stem Cell Network (UKNSCN) annual science meeting will hear today.

Professor Nick Barker of the Institute of Medical Biology in Singapore will explain how he and his team identified that the stem cells which are crucial to maintaining a healthy intestine are also the site at which bowel cancers first begin, and how he also hopes to use healthy stem cells to regenerate tissues to help patients with Crohn's disease and some cancers.

Having discovered a gene that is only turned on in these particular stem cells Professor Barker and his team have been able to isolate the cells in mice and grow small pieces of intestine in the lab. The researchers hope that if they are able to grow larger pieces, they will be able to produce transplant tissues to replace damaged intestines.

Professor Barker explains: "Processing our dinner every day is a tough job so the lining of our intestines quickly get worn out. To keep the intestine working stem cells in little pockets along the surface replace the lining, cell by cell, about once a week.

"We already knew these stem cells existed for a while we didn't know much about them because it was difficult to distinguish them from all of the other types of cells in our intestines. Our team was able to single them out and study them because we discovered a gene that is only turned on in these particular stem cells."

Once the researchers had found this gene they were able to track where the stem cells occur throughout the body finding that, as well as the intestine, the stomach lining and in hair follicles, the cells were also present in bowel tumours.

Professor Barker continues: "We hope that studying these stem cells will be doubly useful: One day we hope to grow large enough pieces in the lab to form replacement tissues for transplant; and by studying the cells we will be able to find new ways to prevent them from mutating and hence leading to cancer.

"Bowel cancer is the third most common type of cancer in England and an estimated 38,000 new cases are diagnosed each year. We know these stem cells are both implicated in causing the cancer but that they also could be useful for treating disease so we hope that studying them will help us to understand how to attack the disease on two fronts.


'/>"/>

Contact: Mike Davies
mike.davies@bbsrc.ac.uk
01-793-414-694
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related medicine news :

1. Attacking cancer cells with hydrogel nanoparticles
2. APHA 2010: Attacking the drinking culture on college campuses from different directions
3. Inflammatory Bowel Ups Risk for Blood Clots
4. Bowel disease link to blood clots
5. NIH grant will create behavioral health registry for pediatric inflammatory bowel disease
6. Colonoscopy Not Needed for Most With Irritable Bowel Syndrome
7. Shift workers at more risk for irritable bowel syndrome, U-M study says
8. Shift Work Linked to Irritable Bowel Syndrome
9. LetsTalkIBS.com Helps Patients Start the Conversation about Irritable Bowel Syndrome
10. Quick new screening exam could save thousands of people from bowel cancer
11. First Annual Observance of World IBD Day Draws Awareness to Growing Global Incidence of Inflammatory Bowel Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... 23, 2017 , ... Military Connection friend and veteran advocate Micaela ... Virgin Atlantic lounge. , Bensko is no stranger to the plight of the ... her life to supporting our wounded veterans. A world-class photographer, her riveting photos “The ...
(Date:6/23/2017)... ... 23, 2017 , ... The Aesthetic Channel has recently highlighted Dr. Ben Talei’s ... with a proprietary technique that he calls the AuraLyft Facelift. The AuraLyft ... ages, patients can expect to look refreshed, rejuvenated, and revitalized. , Dr. Talei’s ...
(Date:6/23/2017)... ... ... 21 Middle East and South Asia Leaders Selected as Eisenhower Fellows , ... in 11 countries across the Middle East and South Asia to embark on a ... and ideas with the leading minds in their fields. , For the first ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ross Insurance Agency ( http://www.rossinsuranceagency.com ... Emergency Management Agency’s (FEMA) recent update of flood zones, more people than ever ... Act was enacted to reflect the actual risk in flood zone areas during ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Katyl ... services to families and business owners in and around Lackawanna County, is joining ... citizens in the area. , Meals on Wheels of NEPA provides hand-delivered and ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... June 16, 2017  Exactly 50 years ago today, the ... later became known as the San Francisco "Summer of Love."  ... unveiling two radical innovations in strategic market research portals that ... marks the beginning of Northern Light,s "Summer of Love (For ... ...
(Date:6/14/2017)... June 14, 2017  In 2016, Embodied Labs ... pitch competition and came away with $25,000 in ... described by Forbes as "entering the life of another" ... as teaching "empathy to medical professionals in an entirely ... recently named a finalist for the Department of Education,s ...
(Date:6/11/2017)... INDIANAPOLIS , June 10, 2017  Eli Lilly and ... results from three Phase 3 studies of galcanezumab, an ... migraine, including late-breaking data on several key secondary endpoints ... Detailed results from these studies (EVOLVE-1, EVOLVE-2 and REGAIN) ... (AHS) annual scientific meeting in Boston ...
Breaking Medicine Technology: