Navigation Links
Attacking bowel cancer on 2 fronts
Date:3/30/2011

Stem cells in the intestine, which when they mutate can lead to bowel cancers, might also be grown into transplant tissues to combat the effects of those same cancers, the UK National Stem Cell Network (UKNSCN) annual science meeting will hear today.

Professor Nick Barker of the Institute of Medical Biology in Singapore will explain how he and his team identified that the stem cells which are crucial to maintaining a healthy intestine are also the site at which bowel cancers first begin, and how he also hopes to use healthy stem cells to regenerate tissues to help patients with Crohn's disease and some cancers.

Having discovered a gene that is only turned on in these particular stem cells Professor Barker and his team have been able to isolate the cells in mice and grow small pieces of intestine in the lab. The researchers hope that if they are able to grow larger pieces, they will be able to produce transplant tissues to replace damaged intestines.

Professor Barker explains: "Processing our dinner every day is a tough job so the lining of our intestines quickly get worn out. To keep the intestine working stem cells in little pockets along the surface replace the lining, cell by cell, about once a week.

"We already knew these stem cells existed for a while we didn't know much about them because it was difficult to distinguish them from all of the other types of cells in our intestines. Our team was able to single them out and study them because we discovered a gene that is only turned on in these particular stem cells."

Once the researchers had found this gene they were able to track where the stem cells occur throughout the body finding that, as well as the intestine, the stomach lining and in hair follicles, the cells were also present in bowel tumours.

Professor Barker continues: "We hope that studying these stem cells will be doubly useful: One day we hope to grow large enough pieces in the lab to form replacement tissues for transplant; and by studying the cells we will be able to find new ways to prevent them from mutating and hence leading to cancer.

"Bowel cancer is the third most common type of cancer in England and an estimated 38,000 new cases are diagnosed each year. We know these stem cells are both implicated in causing the cancer but that they also could be useful for treating disease so we hope that studying them will help us to understand how to attack the disease on two fronts.


'/>"/>

Contact: Mike Davies
mike.davies@bbsrc.ac.uk
01-793-414-694
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related medicine news :

1. Attacking cancer cells with hydrogel nanoparticles
2. APHA 2010: Attacking the drinking culture on college campuses from different directions
3. Inflammatory Bowel Ups Risk for Blood Clots
4. Bowel disease link to blood clots
5. NIH grant will create behavioral health registry for pediatric inflammatory bowel disease
6. Colonoscopy Not Needed for Most With Irritable Bowel Syndrome
7. Shift workers at more risk for irritable bowel syndrome, U-M study says
8. Shift Work Linked to Irritable Bowel Syndrome
9. LetsTalkIBS.com Helps Patients Start the Conversation about Irritable Bowel Syndrome
10. Quick new screening exam could save thousands of people from bowel cancer
11. First Annual Observance of World IBD Day Draws Awareness to Growing Global Incidence of Inflammatory Bowel Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... United ... In Praise of Prevention,” an animated video designed to prevent the ... translations of the video are being distributed throughout Togo, Liberia, Sierra Leone, Nigeria, ...
(Date:2/9/2016)... ... February 09, 2016 , ... The Brain Preservation Foundation’s (BPF) ... from 21st Century Medicine (21CM) ( http://www.21cm.com/ ), spearheaded by recent MIT ... of an intact rabbit brain for extremely long-term storage using a combination of ...
(Date:2/8/2016)... ... 08, 2016 , ... Coast Dental has a new way to help parents ... and family dentist Yvonne Dorrian, DMD, is hosting a free seminar on Friday, February ... to Target at 1207 North Peachtree Parkway in Peachtree City. Dr. Dorrian will have ...
(Date:2/8/2016)... ... February 08, 2016 , ... Brenton Engineering , ... bags, and flow wrapped products at WestPack 2015, February 9-11, in Anaheim, California. ... up to semi-automatic or fully-automatic case packing with a small footprint, rugged, highly ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... IN metro area, has selected the latest beneficiary of their ongoing community enrichment ... to preventing bullying in area schools. Donations are now being accepted at: ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , February 9, 2016 ... gab heute den Abschluss eines Kooperationsvertrags mit ... umfassender Lösungen in den Bereichen Next-Generation-Sequencing (NGS), ... QGEN ; Frankfurt Prime Standard: QIA) gab ... Genomics für die Entwicklung und Förderung umfassender ...
(Date:2/9/2016)... WORCESTER, Mass. , Feb. 9, 2016   ... earned The Joint Commission,s Gold Seal of Approval ® ... continuous compliance with its performance standards. The Gold Seal ... that reflects an organization,s commitment to providing safe and ... --> AllCare Plus Pharmacy underwent a rigorous on-site ...
(Date:2/9/2016)... The leader in accelerated orthodontics, OrthoAccel ® ... the recipient of the 2015 Townie Choice Award in ... medical device that speeds up orthodontic tooth movement by ... associated with treatment, AcceleDent was selected by orthodontists from ... Orthotown survey of the most reliable and reputable ...
Breaking Medicine Technology: