Navigation Links
Atomic structure of essential circadian clock protein complex determined
Date:5/30/2014

Structural biologists have made important progress towards better understanding the functioning of the circadian clock. The circadian or inner clock coordinates the sleep-wake rhythm and many other body processes that regulate, for example, metabolism, blood pressure, and the immune system. A research team led by Professor Eva Wolf, recently appointed Professor of Structural Biology at the Institute of General Botany of Johannes Gutenberg University Mainz (JGU) and Adjunct Director at the Institute of Molecular Biology (IMB), has for the first time identified the molecular structure of a protein complex that plays an important role in regulating the circadian rhythm. At the same time, they also made a surprising discovery: The protein complex contains a zinc ion, which apparently stabilizes it. These results could form the basis for new strategies for treating illnesses that are the result of circadian clock dysfunction.

"Our circadian clock controls many important physiological functions," explained Professor Eva Wolf. If the natural rhythm is disrupted, as for example in the case of people on shift work, the likelihood of developing metabolic disorders, diabetes, or cancer is significantly increased. The fundamental research conducted in the Wolf group is focused on obtaining insight into the molecular mechanisms of the circadian clock. Among the currently investigated topics are the cryptochromes, a class of proteins associated with the circadian clock in mammals. In addition to regulating circadian rhythm, these also control glucose homeostasis and blood sugar levels. Together with another clock protein called period they form a complex, the structure of which has just been determined by Wolf's team.

By x-ray analysis of the cryptochrome-period complex structure, the researchers were able to observe atomic details of the interaction between the cryptochrome and period proteins and also discovered that the zinc ion mediates this interaction. "The metal ion stabilizes the complex and also appears to influence an adjacent disulfide bond," clarified Wolf. Cell biological studies conducted in the collaborating group of Prof. Dr. Achim Kramer at the Charite Berlin showed that this also is the case in human cells.

The researchers had not expected to detect a disulfide bond in the presence of the redox state that prevails in the cytoplasm and the cell nucleus. Its existence is probably regulated by the zinc ion and the disulfide bond itself is perhaps a sensor that indicates the metabolic status of the cell.

"We assume that the formation of this cryptochrome-period protein complex provides a mechanism by which the circadian clock interacts with the metabolism, while the zinc ion and the disulfide bond play an important role in regulating the stability of the complex," summarized Wolf. The now Mainz-based biologist hopes that further findings about the basic functioning of the cryptochrome-period complex and her aim of determining the interaction patterns of further clock proteins may help in the development of future medical treatments.


'/>"/>
Contact: Professor Dr. Eva Wolf
evawolf1@uni-mainz.de
49-613-139-21701
Johannes Gutenberg Universitaet Mainz
Source:Eurekalert

Related medicine news :

1. Global Spectrometry Market (Atomic, Molecular and Mass Spectrometry) – Scenario, Trends, Industry Analysis, Size, Share & Forecast 2011 – 2017
2. Despite missing primary efficacy endpoint, ATOMIC-AHF identifies positive trends
3. Scientists scan the human heart to create digital anatomical library
4. Researchers develop new anatomically based classification for diagnosing cervical spinal stenosis
5. Creatures of habit: Disorders of compulsivity share common pattern and brain structure
6. Being born 4-6 weeks premature can affect brain structure, function
7. Kinesin-5 structure opens cancer drug targets
8. Males and females differ in specific brain structures
9. DNA-built nanostructures safely target, image cancer tumors
10. Brain structure shows who is most sensitive to pain
11. Bacterial Skin and Skin Structure Infections Market: SSSI Pipeline Review, H2 2013 at ReportsnReports.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its first-ever ... Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding work ... Practice and Pediatric Emergency Medicine Practice. , “With this award, we recognize ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 The vast majority of ... dialysis facility.  Treatments are usually 3 times a week, ... visit, including travel time, equipment preparation and wait time. ... especially grueling for patients who are elderly and frail.  ... nursing and rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... , June 23, 2016  Experian Health, ... and transforming the patient payment and care ... innovative new products and services that will ... revenue cycle offerings. These award-winning solutions will ... workflows, remain compliant in an ever-changing environment ...
(Date:6/23/2016)... WASHINGTON , June 23, 2016  The ... Pharmaceuticals has joined the health policy research organization ... Steven Romano , MD, senior vice president and ... his company,s representative on the NPC Board of ... are pleased that Mallinckrodt has joined us in ...
Breaking Medicine Technology: