Navigation Links
Atomic structure discovered for a sodium channel that generates electrical signals in living cells
Date:7/13/2011

pain, epilepsy and cardiac arrhythmias as well as for local and regional anesthesia -- act on sodium channels.

"When you get a spinal block or your dentist gives you a numbing injection, the local anesthetic drugs temporarily shut down sodium channels in the area of the procedure and prevent your brain from receiving the bad news from your nerves," Catterall said.

Over more than three decades, Catterall's lab and others at the UW have made many major discoveries about these tiny pores.

"But we had only a fuzzy, partial view of what the channels looked like," he said. "Now we have a much more detailed picture."

The ability to visualize the atomic structural details of the sodium channel was made possible by use of advanced methods of X-ray crystallography and data analysis in the laboratory of Ning Zheng, associate professor of pharmacology.

"A major problem in studying sodium channels is that they want to be in a cell membrane," Catterall said. New biochemical techniques allowed the research team to extract and purify bacterial sodium channels that they had expressed in the cell membranes of insect cells, and keep them in a stable, functional form for determination of their structure.

"Because of the importance of knowing the atomic structure of sodium channels, many labs have tried to work on it with no success," Zheng said. "We succeeded thanks to the collaborative approach we took and the right combination of talent, expertise, and resources." Payandeh, the first author of the paper, integrated expertise from both the Zheng and Catterall labs and his own past experience to tackle the challenge.

The structure emerged gradually over several months of laborious study.

"We all thought 'Eureka!' but nobody said it," Catterall said, recalling when he and his colleagues realized what they had accomplished.

Examining kinetic models of its intricate molecular structure will tell scie
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Researchers find anatomic differences after robotic-assisted radical prostatectomy
2. Radiation exposure poses similar risk of first and second cancers in atomic bomb survivors
3. Leonardos anatomical sketches fascinate modern-day anatomist
4. Autism changes molecular structure of the brain, UCLA study finds
5. Structured Exercise Programs Help Lower Blood Sugar, Study Finds
6. Facial structure of men and women has become more similar over time
7. Biomarker-driven science at the heart of new ACRIN-ECOG structure
8. Finding of long-sought drug target structure may expedite drug discovery
9. Scientists develop method to identify fleetingly ordered protein structures
10. Mindfulness meditation training changes brain structure in 8 weeks
11. Scientists Map Key Structure HIV Uses to Infect Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... ... 2015 , ... Egg freezing is becoming an increasingly popular option ... As Dr. Michael Kettel explained in an article from the San ... for previous generations who had to make choices between their fertility and their career ...
(Date:7/28/2015)... San Antonio, TX (PRWEB) , ... July 28, 2015 , ... ... in Texas, is now offering the duodenal switch weight loss surgery procedure. ... weight management and bariatric surgery procedures, BMI of Texas is one of ...
(Date:7/28/2015)... , ... July 28, 2015 , ... Bipolar disorder is ... a day to a few times a year. The World Health Organization (WHO) has ... the National Institute of Mental Health reveals that the United States has the highest ...
(Date:7/28/2015)... ... July 28, 2015 , ... ... biologic-device combination products for the treatment of bone disorders and conditions of hair ... 9,062,300 entitled "Fusion Proteins of Collagen Binding-Domain and Parathyroid Hormone". The issued patent ...
(Date:7/28/2015)... York, NY (PRWEB) , ... July 28, 2015 ... ... benefit management services to include a proprietary, web based clinical knowledge system, called ... that are evidence based. It provides physicians who are anticipating making a ...
Breaking Medicine News(10 mins):Health News:Dr. Michael Kettel of San Diego Fertilty Center Interviewed by the San Diego Union-Tribune on Egg Freezing 2Health News:Dr. Michael Kettel of San Diego Fertilty Center Interviewed by the San Diego Union-Tribune on Egg Freezing 3Health News:BMI of Texas Now Offering Duodenal Switch Surgery – Weight Loss Procedure Helps Obese Patients Lose Weight Quickly 2Health News:BMI of Texas Now Offering Duodenal Switch Surgery – Weight Loss Procedure Helps Obese Patients Lose Weight Quickly 3Health News:"I Am Not I" Music Video Raises Bipolar Disorder Awareness 2Health News:BiologicsMD, Inc. Announces Additional US Patent Issuance Covering Company’s Pipeline of Targeted Therapies 2Health News:Introducing Care to Care’s New Web Based “Referral Guidance” Program 2
... Calif., July 2 SuperGen, Inc.,(Nasdaq: SUPG ... rapid,development and commercialization of therapies for solid tumors ... Ph.D.,President and Chief Executive Officer, is scheduled to ... July 9, 2008 at the,Mandarin Oriental Hotel in ...
... Display Paintings at Grumpy,s Cafe; Works on Sale ... Shore Hospital,s Festival of the Arts, CLEVELAND, July 2 ... Home Art Program is now on display at Grumpy,s,Cafe, 2621 ... The exhibition includes several paintings from residents of Joseph,s,Home, a ...
... SXC Health Solutions Corp.,("SXC" or the "Company") ... leading provider of,technology and pharmacy benefits management ... informedRx suite of services with The University,of ... renewal include: RxCLAIM(R),for on-line adjudication services of ...
... supporting Lactation, Consultants, Midwives, Doulas, and Childbirth Educators, giving them ... and expand their, practices by connecting with the 2 million ... ... BOULDER, Colo., July 2 Breastfeeding.com, a premier,online resource with ...
... most powerful anti-inflammatory system, controlling digestion, detoxification, glucose metabolism as well ... nourish the cell membranes of neurons for unprecedented results in fighting ... improving energy, immune and brain function*. , ... Los ...
... should understand and consider the economic impact of new ... report appearing in the July/August issue of CA: ... of the American Cancer Society. The report says health ... to be aware of the relative costs and benefits ...
Cached Medicine News:Health News:SuperGen to Present at the Collins Stewart Growth Conference on July 9, 2008 2Health News:Artwork by Homeless Men on Display in Tremont Cafe 2Health News:Artwork by Homeless Men on Display in Tremont Cafe 3Health News:SXC Health Solutions announces informedRx renewal contract with The University of Michigan 2Health News:Breastfeeding.com Launches First Ever Social Network for Birth-Related Medical Professionals 2Health News:Breakthrough "Neuro Nutrition" Targets the Brain and Vagus Nerve To Boost the Body's Immune, Hormone and Neurological Systems 2Health News:Breakthrough "Neuro Nutrition" Targets the Brain and Vagus Nerve To Boost the Body's Immune, Hormone and Neurological Systems 3Health News:Breakthrough "Neuro Nutrition" Targets the Brain and Vagus Nerve To Boost the Body's Immune, Hormone and Neurological Systems 4Health News:Breakthrough "Neuro Nutrition" Targets the Brain and Vagus Nerve To Boost the Body's Immune, Hormone and Neurological Systems 5Health News:Report says clinicians should consider economic impact of new interventions 2
(Date:7/28/2015)... 2015 Baebies, Inc. today announced the completion ... The oversubscribed round of financing included key investors Rex ... Cunning Capital, Triad, LLC, the Duke Angel Network and ... of Advanced Liquid Logic,s (ALL) former investors including Charleston ... "Rex is pleased to support this promising ...
(Date:7/28/2015)... -- Xencor, Inc. (NASDAQ: XNCR ), a clinical-stage biopharmaceutical ... autoimmune diseases, asthma and allergic diseases, and cancer, announced ... after the market closes on Tuesday, August 4, 2015. ... the same day at 4:30 p.m. ET (1:30 p.m. ... corporate update. The live call may be ...
(Date:7/28/2015)... Oncology, Inc. (OTC: CSBR), engaged in the development of ... and use of oncology drugs, today announced its financial ... Fourth Quarter and Recent Business Highlights: , ... period result , Procured a quarterly record high ... Champions Oncology CEO, stated, "The end of fiscal 2015 ...
Breaking Medicine Technology:Baebies, Inc. Raises $13 Million in Oversubscribed Round of Financing 2Xencor to Host Second Quarter 2015 Financial Results Webcast and Conference Call on August 4, 2015 2Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 2Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 3Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 4Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 5Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 6Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 7Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 8Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 9Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 10Champions Oncology Reports Results for Quarter and Full Year Ended April 30, 2015 11
... MISSISSAUGA, Ontario, Aug. 23, 2011 Valeant Pharmaceuticals International, ... has filed a Notice of Intention to make a ... (the "TSX") and that the TSX has accepted the ... have the right to purchase for cancellation, commencing August ...
... BOSTON, Aug. 23, 2011 Solos Endoscopy, Inc. (OTCPK: SNDY) ... will result in the reduction of more than $620,000 in ... settlement agreement and new consulting agreement will result in a ... Solos Endoscopy posted its financial statements for period ended June ...
Cached Medicine Technology:Valeant Pharmaceuticals Files a Notice of Intention to Make a Normal Course Issuer Bid 2Valeant Pharmaceuticals Files a Notice of Intention to Make a Normal Course Issuer Bid 3Solos Endoscopy to Reduce Debt by Over $620,000 2