Navigation Links
Atomic structure discovered for a sodium channel that generates electrical signals in living cells
Date:7/13/2011

pain, epilepsy and cardiac arrhythmias as well as for local and regional anesthesia -- act on sodium channels.

"When you get a spinal block or your dentist gives you a numbing injection, the local anesthetic drugs temporarily shut down sodium channels in the area of the procedure and prevent your brain from receiving the bad news from your nerves," Catterall said.

Over more than three decades, Catterall's lab and others at the UW have made many major discoveries about these tiny pores.

"But we had only a fuzzy, partial view of what the channels looked like," he said. "Now we have a much more detailed picture."

The ability to visualize the atomic structural details of the sodium channel was made possible by use of advanced methods of X-ray crystallography and data analysis in the laboratory of Ning Zheng, associate professor of pharmacology.

"A major problem in studying sodium channels is that they want to be in a cell membrane," Catterall said. New biochemical techniques allowed the research team to extract and purify bacterial sodium channels that they had expressed in the cell membranes of insect cells, and keep them in a stable, functional form for determination of their structure.

"Because of the importance of knowing the atomic structure of sodium channels, many labs have tried to work on it with no success," Zheng said. "We succeeded thanks to the collaborative approach we took and the right combination of talent, expertise, and resources." Payandeh, the first author of the paper, integrated expertise from both the Zheng and Catterall labs and his own past experience to tackle the challenge.

The structure emerged gradually over several months of laborious study.

"We all thought 'Eureka!' but nobody said it," Catterall said, recalling when he and his colleagues realized what they had accomplished.

Examining kinetic models of its intricate molecular structure will tell scie
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Researchers find anatomic differences after robotic-assisted radical prostatectomy
2. Radiation exposure poses similar risk of first and second cancers in atomic bomb survivors
3. Leonardos anatomical sketches fascinate modern-day anatomist
4. Autism changes molecular structure of the brain, UCLA study finds
5. Structured Exercise Programs Help Lower Blood Sugar, Study Finds
6. Facial structure of men and women has become more similar over time
7. Biomarker-driven science at the heart of new ACRIN-ECOG structure
8. Finding of long-sought drug target structure may expedite drug discovery
9. Scientists develop method to identify fleetingly ordered protein structures
10. Mindfulness meditation training changes brain structure in 8 weeks
11. Scientists Map Key Structure HIV Uses to Infect Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... The Walk a Mile Project, as part of their documentary ... their 3rd research sequence. The new sequence focuses on ... was and is a massive component of GMO regulation in ... World Films. “We started our research by going way ... food supply, just to get a bird's eye and big ...
(Date:3/31/2015)... Scotch Plains, NJ (PRWEB) March 31, 2015 ... breast care to all patients in a calm and caring ... specialists in the diagnosis and surgical treatment of breast cancer. ... the tri-state area but from all over the world. ... national and local publications. , The seeds for Summit Breast ...
(Date:3/31/2015)... TX (PRWEB) March 31, 2015 One of the ... be a visit to Mount Kilauea on the big island. ... few places where you can see molten lava slowly oozing at ... on earth. , One place you would never expect ... the flat, arid terrain of Mission, Texas -- until now. , ...
(Date:3/31/2015)... Virginia (PRWEB) March 31, 2015 ... with Care Investment Trust LLC ("Care") a seniors ... Tiptree Financial Inc. Care announces today, their acquisition ... party seller for $54.48 million. Concurrent with the ... affiliates of Greenfield Senior Living ("Greenfield"). Pursuant to ...
(Date:3/31/2015)... NJ (PRWEB) March 31, 2015 ... of Health Care Administrators (ACHCA) elected two administrators ... short- and long-term care in New Jersey, to ... election of new officers. Robert Reyes, administrator for ... was elected president, and Yael Herman, administrator of ...
Breaking Medicine News(10 mins):Health News:The Walk a Mile Project Launches New Research Sequence on Substantial Equivalence of GMOs 2Health News:Summit Breast Care is Celebrating Four Years as "NJ Top Docs" 2Health News:Rare Volcano Constructed inside Gold’s Gym in Mission, Texas 2Health News:Rare Volcano Constructed inside Gold’s Gym in Mission, Texas 3Health News:Greenfield Senior Living Inc. Enters Lease Transaction with Care Investment Trust LLC 2Health News:Greenfield Senior Living Inc. Enters Lease Transaction with Care Investment Trust LLC 3Health News:Abingdon Care & Rehabilitation Center’s Administrator Elected President of N.J. Chapter of the American College of Health Care Administrators 2
... May 19 Pennsylvania,Secretary of Health Dr. Calvin B. ... vaccination during an immunization clinic,at a shelter in Harrisburg., ... Hepatitis B and,Hepatitis A because they usually do not ... said Dr. Johnson. "While we must reach out to,vulnerable ...
... May 19 The Epilepsy,Foundation today released important information ... the wake of recent news about,Senator Edward Kennedy (D-Mass)., ... of the U. S.,Senate, reportedly experienced a seizure on ... in the brain. One in ten Americans,will have a ...
... such as bread, pasta, often goes unnoticed , , MONDAY, ... to improved diagnosis and treatment of celiac disease, according ... in San Diego. , Celiac disease, which affects ... autoimmune disorder in the small intestine triggered by a ...
... goal of developing reliable genetic tests to guide lung ... Columbia University recently evaluated the ability of five high-risk ... cancer would recur in patients whose non-small cell lung ... present their findings at the American Thoracic Societys 2008 ...
... today announced,that Quest Diagnostics (NYSE: DGX ), ... services, has signed a multi-year,agreement to use the ... viral load testing., Physicians use the test ... measuring changes in HIV-1 RNA levels. Roche,s,newest HIV-1 ...
... Report Outlines Retirement Risks and Identifies ... Approaches to Manage Those Risks, SCHAUMBURG, Ill., ... the unprecedented cost of gas, inflation is affecting every,American. Among the ... to retirement and current retirees who are experiencing,soaring costs in a ...
Cached Medicine News:Health News:PA Health Department Provides Hepatitis B Vaccinations, Discusses Risk Factors 2Health News:The Epilepsy Foundation Sheds Light on Seizures 2Health News:Advances Aid Treatment, Diagnosis of Celiac Disease 2Health News:Advances Aid Treatment, Diagnosis of Celiac Disease 3Health News:Will lung cancer recur? A genetic test may provide the answer 2Health News:Quest Diagnostics Chooses Roche's Fully Automated, Real-Time HIV-1 Viral Load Monitoring Test For Its Customers in Laboratories Nationwide 2Health News:Inflation Ranks as Today's Top Retirement Concern 2Health News:Inflation Ranks as Today's Top Retirement Concern 3Health News:Inflation Ranks as Today's Top Retirement Concern 4
(Date:3/31/2015)... , March 31, 2015 ... "Life Science and Chemical Instrumentation Market (Chromatography, Electrophoresis, DNA ... Flow Cytometer, Incubator, Fume Hood, Centrifuge) - Global ... Life Science and Chemical Instrumentation Market is expected ... of 6.9% from 2014 to 2019. ...
(Date:3/31/2015)... KENNEBUNK, Maine , March 31, 2015 /PRNewswire/ ... aggregated enrollment in Medicare Advantage (MA) plans in ... approximately 17.3 million people were enrolled in Medicare ... of more than 1.3 million members year-over-year.  54.3 ... the Centers for Medicare and Medicaid Services (CMS), ...
(Date:3/31/2015)... , March 31, 2015  On May 2, ... convene in Santa Monica, CA ... Lung-Sparing Therapies for Malignant Pleural Mesothelioma (MPM), a ... to asbestos and commonly affects the lining of ... by UCLA and the Pacific Mesothelioma Center ...
Breaking Medicine Technology:Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 2Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 3Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 4Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 5Medicare Advantage Enrollment Reaches 17 Million According to Mark Farrah Associates 2Cutting-Edge Research to Be Presented at 5th Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma in Santa Monica 2Cutting-Edge Research to Be Presented at 5th Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma in Santa Monica 3Cutting-Edge Research to Be Presented at 5th Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma in Santa Monica 4
... 4 shelves. Over-sized compressor. Triple ... interior lighting. Self-Contained System No plumbing required. ... Full One Year Warranty on Parts & Labor ... Also available as a chromatography unit ...
Inquire...
... Series refrigerators from Taylor-Wharton are uniquely designed ... convenient box-type storage racks and the lower ... storage. The RackSystems are available in four ... from 750 x 2ml vials to 4800 ...
... Basic ergonomic chairs with concave ... support • Select options like seats, ... • BTP/1Q-PAL chairs are recommended for ... clean room, static control, health care ...
Medicine Products: