Navigation Links
Atherosclerotic plaques formed during a late and limited time period in life
Date:4/8/2011

In a new study performed in humans, researchers from Sweden's Karolinska Institutet have determined the age of atherosclerotic plaques by taking advantage of Carbon-14 (14C) residues in the atmosphere, prevailing after the extensive atomic bomb tests in the 50ties and 60ties. The findings, published in the scientific online journal PLoS ONE, suggest that in most people plaque formation occurs during a relatively short and late time period in life of 3-5 years.

The investigators collected carotid plaques during carotid stenosis surgery at the Stockholm South General Hospital (Sdersjukhuset). The patients were admitted for surgery since their carotid lesions partly obstructed the blood flow to the brain, causing symptoms of insufficient oxygen called Trans Ischemic Attacks (TIA) that in some cases also had lead to strokes.

The plaques were carbon dated at Uppsala University, by using Accelerator Mass Spectrometry (AMS). As a result of the extensive atomic bomb test in the 50-ties and 60-ties, the atmospheric concentration of 14C rapidly increased. Since then the concentration of 14C is declining, which now can be used to determine the time of synthesis of any biological sample.

"We suspected that the plaque would be substantially younger than the patients, who were on average were 68 years old at surgery, but we were surprised when we found that the average age of these plaques was less than 10 years," says Associate Professor Johan Bjrkegren, who lead the study at the Department of Medical Biochemistry and Biophysics.

Another striking finding was that the variation of plaque age was low, suggesting that in most people plaque formation occurs during a relative short and late time span in life (3-5 years). If proven true, the growth of atherosclerotic lesions may be interrupted to prevent clinical manifestation, like TIA and stroke, even in late stages of life, at 60 years of age or possibly later.

During the last years, a number of 14C dating studies have been performed at Karolinska Institutet, revealing new perspectives on common diseases involving, fat cells, neurons and cardiomyopathies. However, unlike previous studies, the current study did not date DNA reflecting cell turn over, but instead the entire atherosclerotic lesion.

The age of plaques was also found to be associated to blood levels of insulin, and plaques with lower age (formed more recently) were found to be more unstable than older plaques and therefore more likely to cause clinical complications.

"The correlation between low plaque age, higher insulin levels and instability is also consistent with our findings of gene activity where younger plaques were characterized with higher activity of genes related to immune responses and oxidative phosphorylation", says Dr Bjrkegren. "However, our study is small and need to be replicated in future, larger clinical studies before we can determine the exact roles of biological age for plaque stability and associated clinical events."


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. MEMS thermal sensor detects pre-atherosclerotic lesions
2. Alzheimers-like brain changes found in cognitively normal elders with amyloid plaques
3. Scripps Research study points to liver, not brain, as origin of Alzheimers plaques
4. Coronary imaging enhances ability to identify plaques likely to cause future heart disease
5. Alzheimers memory problems originate with protein clumps floating in the brain, not amyloid plaques
6. First for Emory -- Rare hand transplant surgery successfully performed at Emory University Hospital
7. Human stem cells transformed into key neurons lost in Alzheimers
8. Study Finds Too Many Surgical Breast Biopsies Performed
9. Most hysterectomies should be performed vaginally or laparoscopically
10. Many U.S. Travelers Uninformed About Health Risks Abroad
11. NOSCAR announces first NOTES transoral and transvaginal gallbladder removals performed as part of US multicenter human trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 19, 2017 , ... “Congratulations! It's A Boy! God’s Gift: A ... their parents and God. “Congratulations! It's A Boy! God’s Gift: A Story of Love” ... Long Island, New York. , Published by Christian Faith Publishing, Dale Anthony and Rachael ...
(Date:8/18/2017)... Lynchburg, VA (PRWEB) , ... August 18, 2017 , ... ... to the Democratic Republic of Congo (DRC) thanks to an ambitious venture that conjoined ... as well as the generous support of the Liberty community. These shoes will save ...
(Date:8/18/2017)... York (PRWEB) , ... August ... ... LLC, d/b/a Quick International, LLC (“Quick”), a highly specialized asset-light logistics provider ... has entered into a definitive agreement to purchase Unitrans International Corporation, a ...
(Date:8/18/2017)... New York, NY (PRWEB) , ... August 18, ... ... the launch of this summer’s edition of “Vision & Hearing,” advocating for active, ... The campaign focuses on resources available for individuals with hearing impairments and shares ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... liquid handling handheld devices. Through an educational webinar, they will present the line ... a chance to learn how easy you can automate everyday pipetting tasks. , ...
Breaking Medicine News(10 mins):
(Date:8/3/2017)... 2017  Opioid addiction and other drugs of abuse, ... and threatening outcomes, were problems taken on directly as ... that support them, met this week. This according to ... drugs of abuse, procalcitonin and acute kidney injury were ... 69th meeting in San Diego, CA. ...
(Date:8/2/2017)... -- Life Flight Network and PeaceHealth Oregon Network announced they renewed ... operational efficiency for patients at hospitals in Eugene ... Grove , and Florence, Oregon , ... Network work collaboratively to move patients who require the highest ... sensitive emergency exists. ...
(Date:7/31/2017)... Pharmacy, Inc. (NYSE: DPLO), has been named one of the ... Crain,s Detroit Business . The annual Crain,s Fast ... growth. This year,s edition measures growth from 2013 to 2016. ... list, visit crainsdetroit.com/awards/fast_50/2017 .  "Being named ... Phil Hagerman , CEO and chairman of Diplomat. "We,ve made ...
Breaking Medicine Technology: