Navigation Links
Atherosclerotic plaques formed during a late and limited time period in life
Date:4/8/2011

In a new study performed in humans, researchers from Sweden's Karolinska Institutet have determined the age of atherosclerotic plaques by taking advantage of Carbon-14 (14C) residues in the atmosphere, prevailing after the extensive atomic bomb tests in the 50ties and 60ties. The findings, published in the scientific online journal PLoS ONE, suggest that in most people plaque formation occurs during a relatively short and late time period in life of 3-5 years.

The investigators collected carotid plaques during carotid stenosis surgery at the Stockholm South General Hospital (Sdersjukhuset). The patients were admitted for surgery since their carotid lesions partly obstructed the blood flow to the brain, causing symptoms of insufficient oxygen called Trans Ischemic Attacks (TIA) that in some cases also had lead to strokes.

The plaques were carbon dated at Uppsala University, by using Accelerator Mass Spectrometry (AMS). As a result of the extensive atomic bomb test in the 50-ties and 60-ties, the atmospheric concentration of 14C rapidly increased. Since then the concentration of 14C is declining, which now can be used to determine the time of synthesis of any biological sample.

"We suspected that the plaque would be substantially younger than the patients, who were on average were 68 years old at surgery, but we were surprised when we found that the average age of these plaques was less than 10 years," says Associate Professor Johan Bjrkegren, who lead the study at the Department of Medical Biochemistry and Biophysics.

Another striking finding was that the variation of plaque age was low, suggesting that in most people plaque formation occurs during a relative short and late time span in life (3-5 years). If proven true, the growth of atherosclerotic lesions may be interrupted to prevent clinical manifestation, like TIA and stroke, even in late stages of life, at 60 years of age or possibly later.

During the last years, a number of 14C dating studies have been performed at Karolinska Institutet, revealing new perspectives on common diseases involving, fat cells, neurons and cardiomyopathies. However, unlike previous studies, the current study did not date DNA reflecting cell turn over, but instead the entire atherosclerotic lesion.

The age of plaques was also found to be associated to blood levels of insulin, and plaques with lower age (formed more recently) were found to be more unstable than older plaques and therefore more likely to cause clinical complications.

"The correlation between low plaque age, higher insulin levels and instability is also consistent with our findings of gene activity where younger plaques were characterized with higher activity of genes related to immune responses and oxidative phosphorylation", says Dr Bjrkegren. "However, our study is small and need to be replicated in future, larger clinical studies before we can determine the exact roles of biological age for plaque stability and associated clinical events."


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. MEMS thermal sensor detects pre-atherosclerotic lesions
2. Alzheimers-like brain changes found in cognitively normal elders with amyloid plaques
3. Scripps Research study points to liver, not brain, as origin of Alzheimers plaques
4. Coronary imaging enhances ability to identify plaques likely to cause future heart disease
5. Alzheimers memory problems originate with protein clumps floating in the brain, not amyloid plaques
6. First for Emory -- Rare hand transplant surgery successfully performed at Emory University Hospital
7. Human stem cells transformed into key neurons lost in Alzheimers
8. Study Finds Too Many Surgical Breast Biopsies Performed
9. Most hysterectomies should be performed vaginally or laparoscopically
10. Many U.S. Travelers Uninformed About Health Risks Abroad
11. NOSCAR announces first NOTES transoral and transvaginal gallbladder removals performed as part of US multicenter human trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... 02, 2016 , ... According to an American Psychological Association article, ... abused before the age of 18. Of those who survive, many still face effects ... , In her new book, Lyah! Lyah! Pants on Fyah!, she shares stories ...
(Date:5/2/2016)... PARSIPPANY, N.J. (PRWEB) , ... May 02, 2016 ... ... - Healthcare Research & Analytics EVP and GM Jim Callandrillo and Duane ... during the 55th Annual Pharmaceutical Business Intelligence and Research Group (PBIRG) General ...
(Date:5/2/2016)... ... May 02, 2016 , ... The Evolve Paddle Board Company- which ... announced today the outcome of their partnership with Yoloha Yoga- producers of high quality ... Board.” , SUP yoga has seen a dramatic rise in popularity throughout the last ...
(Date:5/2/2016)... ... , ... Marshall Votta, Josh Holmes and Laura Sandman have joined RowdMap, Inc. ... Inc.’s market growth across both health plans and provider organizations who use government benchmark ... based care. , Marshall Votta joins RowdMap, Inc. as Chief Market Officer and takes ...
(Date:5/1/2016)... ... ... 2 is a set of versatile and smooth logo reveals built exclusively for Final ... a unique logo reveal in just a matter of minutes. Custom settings give the user ... add a uniquely animated logo to any photos or videos. , ProBrand Reveal comes packaged ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016   Click here ... Pharmacy, Inc. (NYSE: DPLO), the nation,s largest independent ... a definitive agreement to acquire Valley Campus Pharmacy, ... ("TNH"), a leading specialty pharmacy that provides individualized ... California . In 2015, TNH generated approximately ...
(Date:4/28/2016)... 28, 2016  The blood testing market in ... to Kalorama Information and The Freedonia Group in a ... acid testing.  The healthcare research firm said that ... blood collection stations and in improving testing at the ... report, Blood Testing Market in China ...
(Date:4/28/2016)... N.J. , April 28, 2016   Acsis ... today announced that leading IT market research and advisory ... " in the IDC MarketScape: Worldwide Pharmaceutical Track and ... 2016).  The report provides an assessment of the capabilities ... track and trace software market. Logo - ...
Breaking Medicine Technology: