Navigation Links
Atherosclerotic plaques formed during a late and limited time period in life
Date:4/8/2011

In a new study performed in humans, researchers from Sweden's Karolinska Institutet have determined the age of atherosclerotic plaques by taking advantage of Carbon-14 (14C) residues in the atmosphere, prevailing after the extensive atomic bomb tests in the 50ties and 60ties. The findings, published in the scientific online journal PLoS ONE, suggest that in most people plaque formation occurs during a relatively short and late time period in life of 3-5 years.

The investigators collected carotid plaques during carotid stenosis surgery at the Stockholm South General Hospital (Sdersjukhuset). The patients were admitted for surgery since their carotid lesions partly obstructed the blood flow to the brain, causing symptoms of insufficient oxygen called Trans Ischemic Attacks (TIA) that in some cases also had lead to strokes.

The plaques were carbon dated at Uppsala University, by using Accelerator Mass Spectrometry (AMS). As a result of the extensive atomic bomb test in the 50-ties and 60-ties, the atmospheric concentration of 14C rapidly increased. Since then the concentration of 14C is declining, which now can be used to determine the time of synthesis of any biological sample.

"We suspected that the plaque would be substantially younger than the patients, who were on average were 68 years old at surgery, but we were surprised when we found that the average age of these plaques was less than 10 years," says Associate Professor Johan Bjrkegren, who lead the study at the Department of Medical Biochemistry and Biophysics.

Another striking finding was that the variation of plaque age was low, suggesting that in most people plaque formation occurs during a relative short and late time span in life (3-5 years). If proven true, the growth of atherosclerotic lesions may be interrupted to prevent clinical manifestation, like TIA and stroke, even in late stages of life, at 60 years of age or possibly later.

During the last years, a number of 14C dating studies have been performed at Karolinska Institutet, revealing new perspectives on common diseases involving, fat cells, neurons and cardiomyopathies. However, unlike previous studies, the current study did not date DNA reflecting cell turn over, but instead the entire atherosclerotic lesion.

The age of plaques was also found to be associated to blood levels of insulin, and plaques with lower age (formed more recently) were found to be more unstable than older plaques and therefore more likely to cause clinical complications.

"The correlation between low plaque age, higher insulin levels and instability is also consistent with our findings of gene activity where younger plaques were characterized with higher activity of genes related to immune responses and oxidative phosphorylation", says Dr Bjrkegren. "However, our study is small and need to be replicated in future, larger clinical studies before we can determine the exact roles of biological age for plaque stability and associated clinical events."


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. MEMS thermal sensor detects pre-atherosclerotic lesions
2. Alzheimers-like brain changes found in cognitively normal elders with amyloid plaques
3. Scripps Research study points to liver, not brain, as origin of Alzheimers plaques
4. Coronary imaging enhances ability to identify plaques likely to cause future heart disease
5. Alzheimers memory problems originate with protein clumps floating in the brain, not amyloid plaques
6. First for Emory -- Rare hand transplant surgery successfully performed at Emory University Hospital
7. Human stem cells transformed into key neurons lost in Alzheimers
8. Study Finds Too Many Surgical Breast Biopsies Performed
9. Most hysterectomies should be performed vaginally or laparoscopically
10. Many U.S. Travelers Uninformed About Health Risks Abroad
11. NOSCAR announces first NOTES transoral and transvaginal gallbladder removals performed as part of US multicenter human trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... Datta Endoscopic ... has joined the revolutionary endoscopic practice under Dr. Datta. Patel is a Board ... Medicine. The patented, revolutionary eDiscSculpt Technique created and used by Datta Endoscopic is ...
(Date:4/28/2017)... Texas (PRWEB) , ... April 28, 2017 , ... The ... plaque in recently to the labor and delivery team at Women’s Hospital at Renaissance ... mothers who give birth at the hospital and decide to donate. , “Women’s ...
(Date:4/28/2017)... Yorba Linda, Ca (PRWEB) , ... April 28, ... ... entities with cardiac or hERG liability could substantially improve drug safety and minimize ... will be provided for validating ion channel inhibition using cell lines and for ...
(Date:4/28/2017)... ... April 28, 2017 , ... Bill Howe started his sewer ... coastal communities. After Tina Howe joined the team, the Bill Howe brand was born ... at affordable rates, and giving back to the San Diego community in which they ...
(Date:4/28/2017)... ... April 28, 2017 , ... Researchers at ... of ActiGraph’s CentrePoint Data Hub in a sample of participants enrolled ... wearable activity and sleep monitoring solutions for the global scientific community. The company’s ...
Breaking Medicine News(10 mins):
(Date:4/26/2017)... N.J. , April 26, 2017 Phoenix Marketing ... its fifteenth year of fulfilling its mission of transforming science ... is highly scrutinized, Phoenix,s innovative approach ... healthcare community about the latest advances in science and medicine ... Phoenix was founded in 2002 by Tracy ...
(Date:4/20/2017)... , April 20, 2017  Cogentix Medical, Inc. ... on providing the Urology, Uro/Gyn and Gynecology markets ... Ash Keswani has joined the Company as Senior ... newly created position, Mr. Keswani will report directly ... "Our organization is delighted that Ash ...
(Date:4/20/2017)... DUBLIN , April 20, 2017 Research ... Delivery Technologies - Innovation Driven by Rapidly Expanding Injectables Market and ... to their offering. ... market for drug delivery technologies will rise from USD 20 Billion ... Global Drug Delivery Technologies - Innovation Driven by Rapidly ...
Breaking Medicine Technology: