Navigation Links
Atherosclerosis found in HIV children

Athens, Greece 5 December 2012: Children with HIV have a 2.5 fold increased risk of atherosclerosis, according to research1 presented at EUROECHO and other Imaging Modalities 2012. Antiretroviral treatment, lipid lowering drugs and prevention with healthy lifestyles are needed to prevent early death from cardiovascular disease.

EUROECHO and other Imaging Modalities 2012 is the annual meeting of the European Association of Cardiovascular Imaging (EACVI)2, a registered branch of the European Society of Cardiology (ESC)3. It takes place 5-8 December in Athens, Greece, at the Megaron Athens International Conference Centre.

Antiretroviral treatment is prolonging the lives of HIV patients, who no longer die prematurely from the infection. But the treatment is not a cure, and the virus remains in the body. "The infection makes the body fight for its life, so the immune system is always activated and there is chronic inflammation," said Dr Talia Sainz Costa, principal investigator of the study and a paediatrician from Madrid, Spain.

In addition, many antiretroviral drugs increase bad (LDL) cholesterol and lower good (HDL) cholesterol. Dr Sainz Costa said: "Children with HIV will have high cholesterol for a long period and on top of that the virus causes chronic inflammation - both are bad for the arteries."

Patients with HIV die 10 years prematurely from non-AIDS disease which includes cardiovascular diseases, cancer, liver and renal diseases. "This is especially important for children because they have been living with HIV since birth or even before," said Dr Sainz Costa. "By the time they are 50 years old they will have accumulated more toxicity from the treatment and more secondary effects from the infection and will be at an even greater risk of heart attacks and other complications."

The present study aimed to discover whether children and adolescents already have early atherosclerosis damage. Carotid intima-media thickness (IMT), a marker of atherosclerosis, was measured using echocardiography in 150 children and adolescents with HIV and 150 age and sex matched healthy controls.

The researchers found that 17% of the HIV group were smokers compared to 11% of the control group. Dr Sainz Costa said: "Smoking levels in adolescents in Spain are known to be high. The even higher levels in the HIV group are probably related to low socioeconomic status and very complex social/family backgrounds."

After adjustment for age, sex, BMI and smoking status, HIV was independently associated with thicker IMT (p=0.005). Children and adolescents had a 2.5 fold increased risk of higher IMT due to HIV. Dr Sainz Costa said: "Our study shows that children and adolescents with HIV have arteries that are more rigid and less elastic, which means that the process of atherosclerosis has begun and they have increased risk of an infarct in the future."

The researchers also found that frequencies of activated T CD4+ cells were higher among HIV-infected children and young adults (p=0.002). "This shows that the immune system is more active," said Dr Sainz Costa.

They concluded that clinicians need to take cardiovascular prevention more seriously in children and adolescents with HIV, while continuing to treat the HIV infection. Dr Sainz Costa said: "Cardiovascular disease has already put down roots in children and adolescents with HIV and we need to take preventive measures at this early stage. We should be more aggressive in treating their high cholesterol with medication this practice is common in adults but rare in children."

She added: "We also need to be stricter about healthy lifestyle advice. Many children and adolescents with HIV come from families with low socioeconomic status and are more prone to smoking, poor diet and inactivity. This age group also struggles with adherence to medication which is another worry, but we should not let this decrease our efforts to prevent future complications."

Dr Sainz Costa concluded: "HIV research is investigating ways to control the inflammation and immune activation with agents such as probiotics, aspirin and corticoids. In the meantime clinicians need to focus on ensuring their young patients with HIV take the antiretroviral treatment, take lipid lowering drugs when necessary, and adopt healthier lifestyles."


Contact: ESC Press Office
European Society of Cardiology

Related medicine news :

1. Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
2. Researchers closer to understanding actions of cells involved in atherosclerosis
3. More Fake Avastin Found in U.S., FDA Says
4. Kessler Foundation names Dr. John Whyte recipient of Foundations 2nd Annual DeLisa Award
5. History of abandoned urban sites found stored in soil
6. Wilderness Medicine founder offers health tips for summer season
7. Concerns about MRSA for expectant mothers may be unfounded
8. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
9. Clues to Slacker Behavior Found in Brain, Study Says
10. Kessler Foundation researchers present at first International Congress on Cognition in MS
11. Biomedical researchers receive Hartwell Foundation awards
Post Your Comments:
(Date:11/30/2015)... ... 30, 2015 , ... According to research by the National ... technicians to be certified or obtain continuing education. To increase awareness of the ... Mouth?” campaign to inform dentists that the technicians they trust could lack the ...
(Date:11/30/2015)... MN (PRWEB) , ... November 30, 2015 , ... ... at . The directory is specialized and only includes chiropractic clinics ... to find a competent and trustworthy alternative health practitioner when back pain sets ...
(Date:11/30/2015)... ... November 30, 2015 , ... The ... this summer, ushering in a new era of publicly accessible automated technology. Now, ... will continue to offer guests an up-close look at the shuttle at MOSI’s ...
(Date:11/30/2015)... Flint, Michigan (PRWEB) , ... November 30, 2015 ... ... a safe and fun atmosphere for Halloween festivities, the Word of Life Christian ... classic children’s board game, and featuring a giant 1.25 ton pile of candy ...
(Date:11/30/2015)... Alexandria, VA (PRWEB) , ... November 30, 2015 ... ... the mesothelioma-affected community across the United States to access life-saving information ... on Malignant Mesothelioma will consist of three individual conferences in three major ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 1, 2015 Express Scripts (NASDAQ: ESRX ) ... IMMY ) to drive access to a low-cost alternative to ... toxoplasmosis that has been recently priced out of reach for ... systems. --> --> Imprimis ... (a form of folic acid) for $1 per capsule for people ...
(Date:11/30/2015)... , Nov. 30, 2015  QT Vascular Ltd., ... and together with its subsidiaries, TriReme Medical LLC and ... company engaged in the design, assembly and distribution of ... vascular disease, is pleased to announce that a three-judge ... Court of Appeals for the Federal Circuit ("Federal Circuit") ...
(Date:11/30/2015)... --  Royal Philips  (NYSE: PHG ; AEX: ... a fully integrated, consultative approach to enhance radiology ... management approaches that combine imaging systems, services, informatics ... delivery and reduce costs. Making its debut at ... Annual Meeting (RSNA) in Chicago ...
Breaking Medicine Technology: