Navigation Links
At the right place at the right time -- new insights into muscle stem cells
Date:9/17/2012

Muscles have a pool of stem cells which provides a source for muscle growth and for regeneration of injured muscles. The stem cells must reside in special niches of the muscle for efficient growth and repair. The developmental biologists Dr. Dominique Brhl and Prof. Carmen Birchmeier of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch have elucidated how these stem cells colonize these niches. At the same time, they show that the stem cells weaken when, due to a mutation, they locate outside of the muscle fibers instead of in their stem cell niches (Developmental Cell, http://dx.doi.org/10.1016/j.devcel.2012.07.014)*.

Muscle stem cells, also called satellite cells, colonize a niche that is located between the plasma membrane of the muscle cell and the surrounding basal lamina. Already in newborns these niches contain satellite cells from which both muscle cells and new stem cells can be generated.

Weakened stem cells

In the present study Dr. Brhl and Professor Birchmeier showed that mouse muscle progenitor cells lacking components of the Notch signaling pathway cannot colonize their niche. Instead the muscle progenitor cells locate in tissue between the muscle fibers. The developmental biologists view this as the cause for the weakening of the muscles. The stem cells that are "in the wrong place" are no longer as potent as they originally were and hardly contribute to muscle growth.

In addition, the Notch signaling pathway has a second function in muscle development. It prevents the differentiation of stem cells into muscle cells through suppression of the muscle developmental factor MyoD and thus ensures that there will always be a pool of stem cells for muscle repair and regeneration. In the future this work could gain in importance for research on muscle regeneration and muscle weakness.


'/>"/>

Contact: Bachtler, Barbara
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1

Related medicine news :

1. Yellow lights mean drivers have to make right choice -- if they have time
2. Joint Replacement Boosts Heart Attack Risk Right After Surgery: Study
3. The Mesothelioma Victims Center Now Offers The Names Of the Best Mesothelioma Attorneys To Senior Citizens Diagnosed With Mesothelioma Because They Have Rights Too
4. Under Right Conditions, Fertility Treatment Can Equal Natural Conception Rates: Study
5. Americans Already Consuming the Right Amount of Salt
6. Victim’s Rights to Recover for Actos Bladder Cancer Could Expire Soon
7. Planting the right messages may make farms safer
8. The bright side of death: Awareness of mortality can result in positive behaviors
9. Choosing the right hospital may save your babys life
10. Close Laundry Detergent Right After Use, Expert Says
11. Knee, Hip Replacements Dont Help People Lose Weight: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... The American ... productivity, stability, even security. Most importantly, employees are the single most important asset ... American workers so unhappy? , Just under half of American workers are emotionally ...
(Date:4/29/2016)... , ... April 29, 2016 , ... Conditions were ideal ... Cove Island Park on Sunday, with sunny skies, a light breeze and temperatures in ... $33,000. , The 5k Run and Walk and 1-mile walk were held ...
(Date:4/29/2016)... ... ... Spine Team Texas, a comprehensive spine physician group specializing in the treatment ... been invited to be a featured speaker at the Texas Society of the American ... 2016. , Dr. R. Scott McPherson, a physical medicine and rehabilitation specialist, will ...
(Date:4/29/2016)... NY (PRWEB) , ... April 29, 2016 , ... ... and engineer of patented products, announces the Gyrociser, an exercise invention which aids ... worth $2 billion," says Scott Cooper, CEO and Creative Director of World Patent ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... Dr. Robert ... dental treatments to improve smiles. Cosmetic dentistry is a fast-growing field as more patients ... offer allows patients to learn more about the options currently available to them and ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)...   Click here for supplemental information regarding ... the nation,s largest independent specialty pharmacy, announced today ... acquire Valley Campus Pharmacy, Inc., doing business as ... pharmacy that provides individualized patient care, based in ... 2015, TNH generated approximately $400 million in revenue. ...
(Date:4/28/2016)... Calif. , April 28, 2016  Marking ... widely accessible breast and ovarian cancer risk test, ... panel analyzing 30 genes that highly impact the ... women. Available today, the Color Test analyzes hereditary ... prostate, stomach, and uterine cancers. The Color Test ...
(Date:4/28/2016)... , April 28, 2016 ... insights on healthcare, announced today that it has been ... Cool Vendor in Life Sciences, 2016, ... 2016.  The report focuses on life-science- oriented analytics, algorithms ... from patients and doctors, confirm medication ingestion, and analyze ...
Breaking Medicine Technology: