Navigation Links
Astrocyte signaling sheds light on stroke research
Date:3/18/2013

BOSTON (March 18, 2013) New research published in The Journal of Neuroscience suggests that modifying signals sent by astrocytes, our star-shaped brain cells, may help to limit the spread of damage after an ischemic brain stroke. The study in mice, by neuroscientists at Tufts University School of Medicine, determined that astrocytes play a critical role in the spread of damage following stroke.

The National Heart Foundation reports that ischemic strokes account for 87% of strokes in the United States. Ischemic strokes are caused by a blood clot that forms and travels to the brain, preventing the flow of blood and oxygen.

Even when blood and oxygen flow is restored, however, neurotransmitter processes in the brain continue to overcompensate for the lack of oxygen, causing brain cells to be damaged. The damage to brain cells often leads to health complications including visual impairment, memory loss, clumsiness, moodiness, and partial or total paralysis.

Research and drug trials have focused primarily on therapies affecting neurons to limit brain cell damage. Phil Haydon's group at Tufts University School of Medicine have focused on astrocytes, a lesser known type of brain cell, as an alternative path to understanding and treating diseases affecting brain cells.

In animal models, his research team has shown that astrocyteswhich outnumber neurons by ten to onesend signals to neurons that can spread the damage caused by strokes. The current study determines that decreasing astrocyte signals limits damage caused by stroke by regulating the neurotransmitter pathways after an ischemic stroke.

The research team compared two sets of mice: a control group with normal astrocyte signaling levels and a group whose signaling was weakened enough to be made protective rather than destructive. To assess the effect of astrocyte protection after ischemic strokes, motor skills, involving tasks such as walking and picking u
'/>"/>

Contact: Siobhan E. Gallagher
siobhan.gallagher@tufts.edu
617-636-6586
Tufts University, Health Sciences Campus
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Kentucky team inhibits Alzheimers biomarkers in animal model by targeting astrocytes
2. Astrocytes identified as target for new depression therapy
3. Inhibiting Hedgehog signaling pathway may improve pancreatic cancer treatment
4. Grb2 holds powerful molecular signaling pathway in check
5. Aurka-to-p53 signaling: A link between stem cell regulation and cancer
6. Scientist receives $2.8 Million to study cell signaling mechanism and develop potential therapeutics
7. Investigational agent targets gene signaling pathways to improve response for patients with CLL
8. Signaling molecule may help stem cells focus on making bone despite age, disease
9. Study sheds new light on role of genetic mutations in colon cancer development
10. Bonobo Genome Sheds Light on Their Links to Chimps, Humans
11. Genetic Research Sheds Light on Jewish Diaspora
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... 2014 The National Association of Hispanic ... Dawn Bazarko, DNP, MPH, RN, and Adriana Perez, PhD, ... Academy of Nursing. They will be inducted with Immediate ... whose induction we reported last May. , Our three ... the 2014 American Academy of Nursing Policy Conference in ...
(Date:9/1/2014)... 01, 2014 Bioinformatics refers to ... analyze biological and genetic data. A major part ... developing software tools to generate and process useful ... with biological computation. While bioinformatics simply makes use ... can its related concepts, biological computation refers to ...
(Date:9/1/2014)... Parties involved in federally-filed Tylenol lawsuits ( http://www.tylenollawsuitclaims.com/ ... in September, where issues related to claims involving the ... of Pennsylvania, Bernstein Liebhard LLP reports. , According ... Court’s website, the meeting is scheduled to take place ... the latest of several Tylenol conferences that have taken ...
(Date:9/1/2014)... Top10BestSEOHosting.com has recently compared many web ... carefully, Top10BestSEOHosting.com is here to announce that JustHost, ... suppliers in 2014. , JustHost ( http://www.justhost.com/track/seohosts ) ... shared hosting plan. The company’s approach to hosting ... affordable, accessible and powerful enough for anyone to ...
(Date:9/1/2014)... Colorado (PRWEB) August 31, 2014 Daily ... an online resource and community that gives members access ... editing resources. , This online resource aims to help ... as well as artists who are looking for inspiration ... Learn more about Tattoo Me Now by visiting the ...
Breaking Medicine News(10 mins):Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 2Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 3Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 4Health News:Bioinformatics Market: A fusion of Computers and Biological Data 2Health News:Bioinformatics Market: A fusion of Computers and Biological Data 3Health News:Bioinformatics Market: A fusion of Computers and Biological Data 4Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 2Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 3Health News:Tylenol Lawsuit News: Bernstein Liebhard LLP Notes Upcoming Status Conference in Pennsylvania Litigation 4Health News:Why Top10BestSEOHosting.com Calls Them Great Web Hosting Suppliers 2Health News:Tattoo Me Now Review Reveals Unique Ideas for Tattoo Designs 2
... Atopy (Allergy) Research Center at the Juntendo University School ... their fecal droppings// disrupt immune system in human skin ... ,Episodes of asthma and eczemas have been ... by other researchers. However the present study conducted in ...
... one of the greatest challenges facing researchers today, and recent ... a growing epidemic.// The World Health Organization has estimated that ... problems, of them nearly 300 million are obese. ... works on the source of the problem – appetite, the ...
... with breast cancer positive to hormone receptors and HER2 ... (anastrozole) from AstraZeneca to their treatment improves the length ... Phase III clinical trial sponsored by Roche showed that ... after which the cancer continued to progress. ...
... more people in the Indian capital Tuesday, taking the total ... situation did not warrant declaring it an epidemic. ,"We ... are well equipped to deal with the situation, hence there ... Minister Yoganand Shastri. ,At an emergency cabinet meeting ...
... specific class of antioxidants found in fruit and vegetable ... ,Non-vitamin antioxidants - polyphenols - are abundant in the ... also present in teas and wines. ,Lab ... potent effect on health, with the potential to significantly ...
... risk of coronary heart diseases, say experts."Coronary heart diseases (CHD) ... oil can reduce the risk of CHD," said S.C. Manchanda//, ... India Institute of Medical Sciences (AIIMS). ,Mustard oil ... the lowest amount of saturated fatty acids and a high ...
Cached Medicine News:Health News:Brain behind the Brawn: Vital Molecule in the Brain Controls Appetite 2Health News:Dengue Outbreak in the Capital is not an Epidemic: Government 2Health News:Mustard Oil can Reduce the Risk of Heart Diseases 2
(Date:8/29/2014)... 29, 2014 According to ... & Services (Equipment, Reagent, Primer, Probe, Custom Oligos), ... QPCR, Gene Synthesis, NGS, DNA, RNAi) - Global ... Oligonucleotide Synthesis Market is expected to reach $1,712.1 ... growing at a CAGR of 9.8% from 2014 ...
(Date:8/29/2014)... , Aug. 29, 2014 Research ... "Global Multiple Sclerosis Drugs Market 2014-2018" report ... a chronic, inflammatory medical condition that results in demyelination, ... because of an abnormal response by the immune system, ... It is a potentially debilitating disease in which the ...
(Date:8/29/2014)... VANCOUVER, British Columbia and MENLO ... -- DelMar Pharmaceuticals, Inc. (OTCQB: DMPI) ("DelMar" ... 2014 fiscal year-end financial statements.  The Company recently changed ... to facilitate an application to list its common stock ... possible. DelMar,s financial statements as filed with ...
Breaking Medicine Technology:Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 4DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 5
Infant Nebulizer Kit W/Misty-Nebulizer 30/CS CE Mark Only...
... Suggested Clinical Applications:, ,Cool Aerosol Therapy. ... open system devices such as aerosol masks, ... that provide only limited FIO2 and limited ... Nebulizer guards against accidental dilution with room ...
... new PARI TREK™ Compact Compressor is for ... aerosol treatments anywhere and everywhere. The compressor ... versatile power source optionsworldwide AC compatibility (100 ... battery, permit patients the freedom to take ...
... ,Allied Healthcares Timeter® PCS 414 portable air ... compressors that you may wonder if its running. ... features a durable, mar-resistant steel case thats easy ... only 26.5 pounds. The PCS 414 has been ...
Medicine Products: