Navigation Links
AstraZeneca Licenses Novel Antidepressant Compounds Discovered by Mayo Clinic and Virginia Tech Collaboration
Date:2/9/2009

Agreement includes research collaboration to generate follow-up TRI compounds

WILMINGTON, Del., Feb. 9 /PRNewswire-FirstCall/ -- AstraZeneca, Mayo Clinic, and Virginia Tech Intellectual Properties Inc. today announced that AstraZeneca has licensed a portfolio of preclinical Triple Reuptake Inhibitor (TRI) compounds for depression. Researchers at Virginia Tech and Mayo Clinic collaborated to discover the compounds. The agreement provides AstraZeneca with a global license for all uses of the compounds, as well as exclusive manufacturing and commercial rights. It also establishes a research collaboration that will focus on jointly generating additional novel TRI compounds. Financial details were not disclosed.

Current classes of antidepressant therapies such as selective serotonin (SSRI) and dual serotonin/norepinephrine (SNRI) reuptake inhibitors are proven treatments for depression and anxiety. However, they only address the imbalances of one or two of the neurotransmitters in the brain.

Paul R. Carlier, Professor of Organic and Medicinal Chemistry at Virginia Tech, explains, "Together with our colleagues at Mayo Clinic, we have been seeking wider-spectrum behavior and have developed a portfolio of TRIs to address imbalances associated with the three major neurotransmitters. Besides incorporating all the benefits associated with serotonin and norepinephrine inhibition, our TRI compounds include the additional action of the dopamine neurotransmitter. We are excited to discover additional compounds that work through this unique mechanism."

Elliott Richelson, M.D., Mayo Clinic, co-inventor of the technology adds, "Through our clinical practice, we recognize the need for improved therapies to treat individuals suffering from depression or anxiety. The additional dopamine action of our TRI compounds has the potential to deliver a superior antidepressant in terms of greater efficacy and an improved side effect profile. By collaborating with AstraZeneca, a company with a strong history of developing new medicines, we have the opportunity to both advance and expand upon these scientific discoveries to address better the needs of patients worldwide."

Christer Kohler, Vice President for AstraZeneca's Global Discovery Research Area focused on Central Nervous System & Pain, says "Besides enabling us to harness the combined power of two outstanding, world-class institutions, this agreement also establishes a strong footing for AstraZeneca in the strategically important TRI research area. We continue to build alliances and collaborations within the scientific community and this deal is another example of our strong commitment and ability to leverage innovation with the aim of making a meaningful difference in patients' lives."

February 9, 2009

NOTES TO EDITORS

About AstraZeneca

AstraZeneca is a major international healthcare business engaged in the research, development, manufacturing and marketing of meaningful prescription medicines and supplier for healthcare services. AstraZeneca is one of the world's leading pharmaceutical companies with healthcare sales of $29.55 billion and is a leader in gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and infectious disease medicines. In the United States, AstraZeneca is a $13.35 billion dollar healthcare business with 12,200 employees committed to improving people's lives. AstraZeneca is listed in the Dow Jones Sustainability Index (Global) as well as the FTSE4Good Index.

For more information visit http://www.astrazeneca-us.com./

About Mayo Clinic's Office of Intellectual Property

Mayo Clinic has one of the most highly evolved intellectual property and technology commercialization efforts in academic medicine, with a 20-year history of supporting Mayo's mission. The Office of Intellectual Property at Mayo Clinic, serves as a bridge between discoveries and the marketplace. Our staff works closely with Mayo physicians and scientists to evaluate and develop inventions, ideas and discoveries that have the potential to transform healthcare and generate income to support Mayo patient care, education and research. At Mayo Clinic, we work with inventors and industry to determine the right fit for each innovation, whether a sponsored research agreement, licensing agreement, technology-based venture, start-up company or entirely new business model. Mayo Clinic's Office of Intellectual Property has filed more than 2,800 patent applications resulting in more than 500 active licensing agreements with companies in the biomedical and manufacturing industries.

For more information, visit www.mayoclinic.org

About Virginia Tech

Founded in 1872 as a land-grant college, Virginia Tech is the most comprehensive university in the Commonwealth of Virginia and is among the top research universities in the nation. The university's nine colleges are dedicated to quality, innovation, and results through teaching, research, and outreach activities. At its main campus in Blacksburg and six other campus centers across the state, Virginia Tech enrolls more than 28,000 undergraduate and graduate students from all 50 states and more than 100 countries in 180 academic degree programs.

About Virginia Tech Intellectual Properties, Inc. (VTIP)

Formed in 1985 as an affiliated corporation of Virginia Tech, VTIP is passionate in its pursuit of excellence in technology commercialization, creating market opportunities from scientific innovation. VTIP facilitates the licensing of technology to companies, encourages new faculty startup ventures, works with publishers and distributors of software, and supports the transfer of research and knowledge to other universities, research institutes and companies. For more information about VTIP, contact Mark Coburn at (540) 951-9378 or visit http://www.vtip.org/.


'/>"/>
SOURCE AstraZeneca
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. AstraZeneca Leads Local Walking Movement
2. AstraZeneca Joins Local Walking Movement
3. Major Pharma Clinical Case Studies From Amgen, AstraZeneca, GSK, Intermune, Cephalon Inc, Sunesis Pharmaceuticals and Dartmouth Medical School During Fall Clinical Focused Programs
4. Verus Pharmaceuticals Announces Divestiture of Pediatric Asthma Development Programs to AstraZeneca
5. AstraZeneca Recognized as One of Working Mothers 100 Best Companies for the Sixth Consecutive Year
6. AstraZeneca Launches New Program to Support Facilities that Connect People to Needed Medical Care and Prescription Assistance
7. NPS Sells Assets Related to mGluR Collaboration to AstraZeneca for $30 Million to Support Late-Stage Product Development
8. Everett-Area Cancer Patients Can More Easily Navigate Health Care System Thanks to the American Cancer Society and AstraZeneca
9. Perrigo Announces that Dexcels Settlement with AstraZeneca Allows OTC Omeprazole Launch Following Final FDA Approval
10. AstraZeneca Response to November 2, 2007 Ruling In Re: Pharmaceutical Industry Average Wholesale Price Litigation, MDL No. 1456, U.S. District Court, District of Massachusetts
11. AstraZeneca Receives Six Months Pediatric Exclusivity Patent Extension for ARIMIDEX(R) (anastrozole) from the FDA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 2016 , ... Marcy was in a crisis. Her son James, eight, was out of control. ... and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... rocks at my other children and say he was going to kill them. If ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their ... Award, an essay contest in which patients and their families pay tribute to a ... the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Grove Investment Group (TGIG), has initiated cultivation and processing operations at its production ... and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system of ...
(Date:6/24/2016)... Washington, D.C. (PRWEB) , ... June 24, 2016 , ... ... Pro-Am Heroes Golf Classic Tournament held on June 20th at the Woodmont Country ... local charity, Luke’s Wings, an organization dedicated to helping service members that have been ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... N.J. , June 24, 2016  Collagen ... the design, development and manufacturing of collagen and ... regeneration announced today that Bill Messer ... and Marketing to further leverage the growing portfolio ... medical devices. Bill joins the Collagen ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
Breaking Medicine Technology: