Navigation Links
Asthma in boys may be just a phase, but for girls it may be there to stay
Date:8/15/2008

Boys may be more apt than girls to have childhood asthma, but, when compared to girls, they are also more likely to grow out of it in adolescence and have a decreased incidence of asthma in the post-pubertal years. This indicates that there may be a buried mechanism in asthma development, according to a prospective study that analyzed airway responsiveness (AR) in more than 1,000 children with mild to moderate asthma over a period of about nine years.

"We wanted to investigate what was behind the observed sex differences in asthma rates and AR," says lead researcher, Kelan G. Tantisira, M.D., M.P.H., of Brigham and Women's Hospital and Harvard Medical School. "This is the first study to prospectively examine the natural history of sex differences in asthma in this manner."

Their results appeared in the second issue for August of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Dr. Tantisira and colleagues used data from the ongoing Childhood Asthma Management Program (CAMP) that enrolled 1041 children from 5 to 12 years of age with mild to moderate persistent asthma and performed annual spirometric testing with methacholine challenges to quantify their AR.

After an average of 8.6 years and each individual had undergone eight to nine annual methacholine challenges, the researchers were able to identify a clear pattern: when it came to the amount of methacholine it took to provoke airway constriction, the girls' reactivity did not change markedly over the years. In contrast, boys became increasingly tolerant over time to larger and larger doses of methacholine, suggesting a possible decrease in disease severity. By the age of 16, it took more than twice as much methacholine to provoke a 20 percent constriction in the boys' airway on average as it did with the girls.

What's more, by age 18, only 14 percent of the girls did not demonstrate any significant degree of airways responsiveness, compared to 27 percent of boys.

"While our results were not unexpected, they do point to intriguing potential mechanisms, to explain the gender differences in asthma incidence and severity. Especially intriguing is that the differences in gender begin at the time of transition into early puberty." said Dr. Tantisira.

This study into the natural history and sex differences in asthma marks the beginning of what many hope will be a long investigation into the subject.

"It will be of great interest to follow these children over time to see what happens with AR and severity of asthma in adulthood," wrote Jorrit Gerritson, M.D., Ph.D., in an accompanying editorial.

This is precisely Dr. Tantisira's next step: Dr. Tantisira and colleagues now have 12 years of data for the cohort, and is looking into investigating the characteristics of the individuals who attained clinically "normal" AR during follow-up. "Most of the original cohort has now reached adulthood," said Dr. Tantisira. "We are now able to perform a secondary analysis with an emphasis on those who have reached clinical 'normalcy.'"


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Genetic predisposition increases childhood asthma risk
2. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
3. New Asthma Guidelines Stress Disease Control
4. Study finds some kids are being misdiagnosed with asthma
5. Childhood asthma still inappropriately treated in the UK
6. Parents perceptions can hamper kids asthma care, study finds
7. Clean to Ease Allergy and Asthma Symptoms
8. Expanding Prevalent Population Will Drive Dramatic Growth for the Asthma Drug Market in China
9. Parents Worries Hamper Kids Asthma Treatment
10. School is Cool for Asthma Patients of All Ages
11. Mold linked to asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... Milford, NJ (PRWEB) , ... December 02, 2016 , ... ... Nothing Water has some unique properties including its unmatched natural purity of just 6 ... as clean and crisp. , Nothing Water has been available in several ShopRite and ...
(Date:12/2/2016)... ... December 02, 2016 , ... Clarify Health ... has raised $6.0 million in an initial round of funding. The round was ... and their caregivers can receive far better care through the application of the ...
(Date:12/2/2016)... ... December 02, 2016 , ... ‘Tis the season for giving! Today, 20 ... the National Family Partnership and the Drug Enforcement Administration as part of the National ... the 10 winning schools who decorated their campuses with this year’s Red Ribbon Week ...
(Date:11/30/2016)... PALMYRA, Wisconsin (PRWEB) , ... November 30, 2016 ... ... inclusion in the 2016 Deloitte Wisconsin 75, an annual ranking and recognition of ... consecutive year on the list, having ranked from 2008-2016. In addition, Standard Process ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... and stylish design wanted by today’s consumers at an affordable price, is now ... says the new watch is “a game changer” when it comes to the ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... in the ECG Cables And ECG Leadwires Market owing to ... devices. On the other hand, the Asia-Pacific ... rate during the forecast period. The market players ... plc ( Ireland ), Koninklijke Philips N.V. ( ... ( China ), held major share of the ...
(Date:12/2/2016)... PUNE, India , December 2, 2016 /PRNewswire/ ... research report "In Vitro Diagnostics/IVD Market by Product ... Diagnostics, Hematology), Application (Diabetes, Oncology, Cardiology, Nephrology, Infectious ... the global market is valued at USD 60.22 ... grow at a CAGR of 5.5% during the ...
(Date:12/2/2016)... On Thursday, December 1st 2016, ... research, development and innovation in the biopharmaceutical industry at ... in the presence of Sergey Tsyb, Vice Minister of ... , Natalia Sanina, First Vice Chairman of the ... of Roszdravnadzor, National Service of Control in Healthcare, Sergey ...
Breaking Medicine Technology: