Navigation Links
Asthma in boys may be just a phase, but for girls it may be there to stay

Boys may be more apt than girls to have childhood asthma, but, when compared to girls, they are also more likely to grow out of it in adolescence and have a decreased incidence of asthma in the post-pubertal years. This indicates that there may be a buried mechanism in asthma development, according to a prospective study that analyzed airway responsiveness (AR) in more than 1,000 children with mild to moderate asthma over a period of about nine years.

"We wanted to investigate what was behind the observed sex differences in asthma rates and AR," says lead researcher, Kelan G. Tantisira, M.D., M.P.H., of Brigham and Women's Hospital and Harvard Medical School. "This is the first study to prospectively examine the natural history of sex differences in asthma in this manner."

Their results appeared in the second issue for August of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Dr. Tantisira and colleagues used data from the ongoing Childhood Asthma Management Program (CAMP) that enrolled 1041 children from 5 to 12 years of age with mild to moderate persistent asthma and performed annual spirometric testing with methacholine challenges to quantify their AR.

After an average of 8.6 years and each individual had undergone eight to nine annual methacholine challenges, the researchers were able to identify a clear pattern: when it came to the amount of methacholine it took to provoke airway constriction, the girls' reactivity did not change markedly over the years. In contrast, boys became increasingly tolerant over time to larger and larger doses of methacholine, suggesting a possible decrease in disease severity. By the age of 16, it took more than twice as much methacholine to provoke a 20 percent constriction in the boys' airway on average as it did with the girls.

What's more, by age 18, only 14 percent of the girls did not demonstrate any significant degree of airways responsiveness, compared to 27 percent of boys.

"While our results were not unexpected, they do point to intriguing potential mechanisms, to explain the gender differences in asthma incidence and severity. Especially intriguing is that the differences in gender begin at the time of transition into early puberty." said Dr. Tantisira.

This study into the natural history and sex differences in asthma marks the beginning of what many hope will be a long investigation into the subject.

"It will be of great interest to follow these children over time to see what happens with AR and severity of asthma in adulthood," wrote Jorrit Gerritson, M.D., Ph.D., in an accompanying editorial.

This is precisely Dr. Tantisira's next step: Dr. Tantisira and colleagues now have 12 years of data for the cohort, and is looking into investigating the characteristics of the individuals who attained clinically "normal" AR during follow-up. "Most of the original cohort has now reached adulthood," said Dr. Tantisira. "We are now able to perform a secondary analysis with an emphasis on those who have reached clinical 'normalcy.'"


Contact: Keely Savoie
American Thoracic Society

Related medicine news :

1. Genetic predisposition increases childhood asthma risk
2. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
3. New Asthma Guidelines Stress Disease Control
4. Study finds some kids are being misdiagnosed with asthma
5. Childhood asthma still inappropriately treated in the UK
6. Parents perceptions can hamper kids asthma care, study finds
7. Clean to Ease Allergy and Asthma Symptoms
8. Expanding Prevalent Population Will Drive Dramatic Growth for the Asthma Drug Market in China
9. Parents Worries Hamper Kids Asthma Treatment
10. School is Cool for Asthma Patients of All Ages
11. Mold linked to asthma
Post Your Comments:
(Date:11/28/2015)... (PRWEB) , ... November 28, 2015 , ... Pixel Film ... customizable media panels to choose from, the possibilities are endless. Users have full control ... With the ProPanel: Pulse masking effects, users are sure to get heads to turn. ...
(Date:11/27/2015)... Denver, CO (PRWEB) , ... November 27, 2015 , ... ... U.S. cities are not changing the way that they are handling security in light ... increasing police and security presence in an attempt to stop an attack from reaching ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... were," said an inventor from Hillside, N.J. "Many people catch diseases simply from ... that individuals will always be protected from germs." , He developed the patent-pending ...
(Date:11/27/2015)... ... ... No.1 Herpes-only dating community in the world, revealed that over 50% of its members are ... people under the age of 50 – or 67% of the population - are infected ... HSV-1 infection . , "The data shocks us highly!" said Michelle Li, Co-Founder of ...
(Date:11/27/2015)... MINNEAPOLIS, Minn. (PRWEB) , ... November 27, 2015 ... ... you start failing. Secura Consultants has prided itself for not only fulfilling the ... best income protection solutions at an affordable price and providing top-tier customer service. ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Une nouvelle approche consistant ... contre le cancer avancé.    --> ... au traitement photodynamique au Bremachlorin contre le cancer ... nouvelle approche consistant à combiner l,immunothérapie au traitement ...    Clinical Cancer Research . ...
(Date:11/27/2015)... ) ... "2016 Global Tumor Marker Testing Market: Supplier ... Segment Forecasts, Innovative Technologies, Instrumentation Review, Competitive ... offering. --> ) has ... Global Tumor Marker Testing Market: Supplier Shares ...
(Date:11/26/2015)... 26, 2015 ... aanpak combineert immunotherapie met Bremachlorin-photodynamische therapie voor ... ) --> ... ) Uit ... Centrum (LUMC) blijkt ...
Breaking Medicine Technology: