Navigation Links
Asthma attack prevention proposal awarded NIH New Innovator grant
Date:9/30/2013

r tested," he said.

Since the first experiments using an extract of a bacterium that causes ear and sinus infections in children, Evans and colleagues have developed a synthetic version that's more amenable to use as a drug. A first-in-humans phase I trial is expected to begin soon, and subsequent clinical trials in patients with leukemia and in patients with asthma have already received funding through other grants.

Inducible resistance

Allergic inflammation has long been identified as a culprit in acute asthma attacks and long-term damage to airways. Inflammation is a primary target of asthma treatment, but anti-inflammatory medicines don't appreciably slow disease progression, Evans said.

Viruses invade the lining of the lungs the epithelial tissue and launch an inflammatory immune response that, left to its own devices in susceptible people, makes the lungs vulnerable to future attacks and promotes asthma progression.

The aerosol developed by Evans and colleagues simulates an infection that stimulates an innate immune system response the fast action component of the immune system that swiftly deploys proteins and reactive oxidative species to destroy invading pathogens.

Ramping up the innate immune system before a viral infection is well-established starts wiping out the infection within hours, their research has found. They call this "good" inflammatory response inducible resistance.

An adaptive immune response, triggered by the innate immune activation, launches a more targeted pathogen-specific response that "remembers" the invader forever but can take days to fully respond.

Crucial components identified, synthesized

From earlier experiments, Evans pinpointed the crucial components of the response to the bacterial aerosol that actually launched the innate immune inflammatory response. He combined two synthetic ligands that bind to two toll-like receptor proteins, ig
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. 2 tests in combination can provide better asthma diagnosis
2. AsthmaMist - Instant Relief for Asthma Finally Made Available With an Extra Bottle Offer
3. San Francisco Health Plan’s Innovative Diabetes Text Messaging Program Expanded to Include Members Affected with Asthma
4. Argan powder found in some cosmetics linked with occupational asthma
5. Good asthma control during pregnancy is vital says new review
6. Menopausal women at greater risk for asthma hospitalization
7. Instant Relief for Asthma Delivered by a New Product Called Asthmamist
8. Experiences of racism linked to adult-onset asthma in African-American women
9. Children with allergy, asthma may be at higher risk for ADHD
10. Exercising with Asthma: Tips to Remember
11. Treatment For Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... Viejo, California (PRWEB) December 26, 2014 Plugin ... announced the TransPack Volume 5 Plugin for Final Cut Pro ... manipulate a hard light tool to pull off an industry ... “When users get their hands on TransPack Volume 5, a ... Volume 5 is a set of over 50 Final Cut ...
(Date:12/26/2014)... December 26, 2014 Parker & ... the best in heating, cooling and plumbing contractor ... hour emergency services in 2014 with regard to ... that Arizona is known for its incredibly hot ... understands the intricacies and details of a wide ...
(Date:12/25/2014)... December 26, 2014 The report “TS-1 ... focuses on the current treatment landscape, unmet needs, current ... TS-1 is an anti-cancer drug which is typically used ... is also used for treating gastric cancer and pancreatic ... potassium. The drug was first approved in 1999 in ...
(Date:12/25/2014)... December 25, 2014 The short film “Color ... created in honor of a true 9/11 hero, Welles Remy ... festivals including the 24 hours of Nuremberg International Short Film ... , Actress, screenwriter and director Luciana Lagana ... film together with her husband, Gregory Graham - ...
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide professional shopping ... of the models at LunaDress.co.uk come with big discounts, up to ... veil can turn out to be a most exciting memory and ... always bring surprise to a wedding. On the updated fashion blog, ... veils for a big day . , Going out with friends ...
Breaking Medicine News(10 mins):Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2
... CHICAGO, Today America's Second Harvest -- The Nation's Food ... food banks and more than 20,000 food service agencies ... legislators in Washington D.C. begin to consider drafts of ... nutrition programs it supports, America's Second Harvest released The ...
... receiving requests from models, actors, dermatologists, skin care professionals ... Inc. recently launched the Bx Pro/Face line. Compared ... available, the Bx Pro/Face formula contains higher doses of ... being lost in one year. Bx Pro/Face further diminishes ...
... Avandia heated up Wednesday as experts pointed to studies linking ... study claimed rosiglitazone is safe. ,The GlaxoSmithKline study ... (NEJM) gave preliminary results of a four-year clinical study of ... heart attacks or death. ,Among the sub-group of ...
... the Chinese government published a five-year plan to intensify ... plan claims that illegal activities behind production and sale ... effectively contained in future. The Chinese government has been ... at home and abroad regarding the poor quality standards ...
... low levels of normal serum potassium in patients with heart ... was conducted by a team of researchers led by Ali ... ,As part of the study, researchers studied 1,187 pairs of ... who were balanced in all measured baseline covariates. The patients ...
... 2004, Christopher Woods, a 29-year old resident in New York, drank ... Pharmaceutical company. ,When he woke up ... away. He had to go for medical advice and for treatment ... ,Priapism is persistent, painful erection of the ...
Cached Medicine News:Health News:Hunger Awareness Day to Shed Light on Surprising Face of Hunger June 5 2Health News:Hunger Awareness Day to Shed Light on Surprising Face of Hunger June 5 3Health News:Controversy Spikes Over Anti-diabetes Drug Avandia 2Health News:China is Cracking Down on Food Safety 2
(Date:12/24/2014)... Dec. 23, 2014  Lockton Dunning Benefits, the ... Companies, announced the addition of Vice President ... Lockton Dunning,s Pharmacy Consulting team, Excelsior Solutions. ... industry experience to the position.  Most recently, she ... at Diplomat Specialty Pharmacy, where she has held ...
(Date:12/24/2014)... Calif. , Dec. 23, 2014 In response ... Doctors, Association of Sierra Leone , Direct ... Leone for the treatment of local health workers ... While a new dedicated Ebola care center was constructed for ... the facility is not available for local Sierra Leonean health ...
(Date:12/22/2014)... Dec. 22, 2014  CytoSorbents Corporation (OTCQB:CTSOD), a ... blood purification technology to help fight deadly inflammation ... countries worldwide, today announced the appointment of Dr. ... as its Senior Vice President of Clinical Development, ... Di Russo is an accomplished pediatric ...
Breaking Medicine Technology:Kim Foerster Joins Lockton Companies 2First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5
... 2012  The new product planning and development process is ... to cost constraints and competitive pressures. New product planning ... 2012 and beyond need an updated road map to ... To that end, Best Practices, LLC ...
... Mich., Jan. 6, 2012  Perrigo Company (Nasdaq: PRGO;TASE) today ... Papa will present at the 30th Annual J.P. ... 10:30 AM (PST) at the Westin St. Francis ... be webcast at the following link: http://jpmorgan.metameetings.com/webcasts/healthcare12/?sessionId=9bb4fd7d0105162325790 ...
Cached Medicine Technology:New Product Planning Excellence Services Program Provides Road Map for Clinical Development Success in the Pharmaceutical Industry 2Perrigo Company to Present at the 30th Annual J.P. Morgan Healthcare Conference 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: