Navigation Links
Asthma and smoker's lung: dry airways play a key role
Date:4/7/2008

Dry airways may not only play a central role in the development of the inherited lung disease cystic fibrosis, but also in much more common acquired chronic lung diseases such as asthma and smokers lung, the cigarette smoke-induced chronic obstructive pulmonary disease (COPD). This is the conclusion reached by scientists at Heidelberg University Hospital under the direction of Assistant Professor Dr. Marcus Mall from the Department of Pediatrics at Heidelberg University Hospital and Professor Dr. Richard Boucher of the University of North Carolina at Chapel Hill. In animal studies, they found that insufficient hydration of the airway surfaces leads to pathologies typical of chronic obstructive lung diseases in humans.

Thus, these findings point to a new approach for the treatment of these diseases, which are listed by the World Health Organization WHO as the fourth leading cause of death world-wide. There are currently no causal therapies available for treating these diseases; only the symptoms such as shortness of breath and oxygen deficiency can be treated. The results of the study have now been published in the American Journal of Respiratory and Critical Care Medicine.

Cystic fibrosis gene causes airways to dry out and thickens mucus

In the hereditary disease cystic fibrosis, which affects about 8,000 people in Germany (about 80,000 people in the Western world), a defective gene causes a change in the transport of salt and water across the mucosal surfaces in the lungs, the intestine and other organs, and thus produce a change in the composition of the secretions.

Using a mouse model he developed, Dr. Mall succeeded in proving a direct relationship between the defective gene and development of lung disease certain sodium channels on the surface of airway cells that are responsible for the resorption of salt and water are hyperactive. The cells absorb too much fluid, causing the airway surfaces to dry out. This
'/>"/>

Contact: Dr. Annette Tuffs
annette.tuffs@med.uni-heidelberg.de
49-622-156-4536
University Hospital Heidelberg
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Actual use of asthma medications contradicts guidelines
2. FDA Probing Possible Link Between Asthma Drug and Suicide Risk
3. London Luxury Receives Asthma & Allergy Friendly(TM) Certification for Several of Its Bedding Products
4. Asthma medicines often not prescribed as national guidelines recommend
5. Study Analyzed Long-Term SYMBICORT(R) Use in Children With Persistent Asthma
6. NIH Asthma Guidelines Will Leave Sufferers Breathing Easier This Spring
7. Leading Autism Expert Kenneth A. Bock, M.D. Launches National Foundation to Provide Financial Assistance to Children with Autism, Allergies, Asthma and ADHD
8. Aspirin Reduces Asthma Risk Among Older Women
9. UniCare of West Virginia Providing Assistance for Asthma Education Training
10. Treatment for mild asthma leads to improved lung function
11. Oral Allergy Immunotherapy Helps Control Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... inexpensive, portable, microchip-based test for diagnosing type-1 diabetes ... better understand the disease, according to the device,s ... , Described in a paper to be published ... the test employs nanotechnology to detect type-1 diabetes ... the two main forms of diabetes mellitus, which ...
(Date:7/13/2014)... Recently, MillionaireCasket.com, a well-known casket manufacturer from China, has ... the company’s chief executive officer has announced a new promotion ... offered at discounted prices, from 15 to 26 percent off. ... in huge demand in the current market. We are excited ... a lot of high quality products for sale. Many of ...
(Date:7/13/2014)... The North American water storage systems market is estimated ... by 2018, at a CAGR of 21.0%, from 2013 to ... rapid pace in North America. The U.S. is experiencing high ... wastewater storage and collection, and the increased spending on modernization ... a healthy rate in Canada, and is rising at a ...
(Date:7/13/2014)... 13, 2014 The report “Micronutrient ... Iron), Form (Chelated & Non Chelated), Application Mode ... Global Trends and Forecast to 2018” defines and ... analysis and forecasting of the global value and ... driving and restraining factors for the global agriculture ...
(Date:7/13/2014)... Fuel additives are chemicals, which are ... fuel, kerosene, and so on, in order to enhance ... the corrosion effects caused by fuels and improving the ... fuel, provide economies of scale in the long run, ... cost of the fuel products. , The various fuel ...
Breaking Medicine News(10 mins):Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 2Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 3Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 4Health News:Cheap Oak Caskets Recently Unveiled By China Casket Manufacturer MillionaireCasket.com 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 2Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 4Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4
... residues in their milk. But antibiotics are sometimes used even ... hours to produce a result and do not test for ... closed, thanks to a fully automated minilab developed by scientists ... gwk Praezisionstechnik GmbH. Even at the best of ...
... investigations, researcher says , FRIDAY, May 7 (HealthDay News) -- ... variations in human eye color. , The researchers, led by ... link eye color in 6,000 Dutch people to their genetic ... sense -- blue, green, brown -- as in previous ...
... ... laundry detergent? In the spirit of Mother’s Day and as a gift to mothers (and fathers) ... applicable for babies as they are for brands. , ... (PRWEB) May 7, 2010 -- What does naming a baby have to do with ...
... ... had a family member or friend in a hospital knows just how stressful ... circle of friends and family. With the launch of a new iPhone tool ... right from your phone, instantly. You can choose who you want to communicate ...
... ... Free Baseball Tickets and More , ... Dublin, Ohio (PRWEB) -- Dynowatt, an independent provider of electricity and green power, ... game. When you “become a fan” of Dynowatt (powered by Accent Energy) on the ...
... ... preliminary shoots for the Pink Ribbon Connection’s annual breast cancer charity calendar. The calendar ... survivors of breast cancer. , ... Indianapolis, IN (PRWEB) May 6, 2010 -- Dario Infini saw a chance to give back ...
Cached Medicine News:Health News:Minilab can quickly identify antibiotic residues in milk, before it leaves the barn 2Health News:Minilab can quickly identify antibiotic residues in milk, before it leaves the barn 3Health News:Mother's Day Special: Catchword's 10 Rules for Branding Your Baby 2Health News:Mother's Day Special: Catchword's 10 Rules for Branding Your Baby 3Health News:Mother's Day Special: Catchword's 10 Rules for Branding Your Baby 4Health News:New "howsthepatient" iPhone App Provides a Simple, Seamless Way to Send Health Updates to Friends and Family 2Health News:New "howsthepatient" iPhone App Provides a Simple, Seamless Way to Send Health Updates to Friends and Family 3Health News:New "howsthepatient" iPhone App Provides a Simple, Seamless Way to Send Health Updates to Friends and Family 4Health News:Dynowatt Offers Facebook Fans a Chance to See the Rangers and Astros Play for Texas Bragging Rights 2Health News:Dynowatt Offers Facebook Fans a Chance to See the Rangers and Astros Play for Texas Bragging Rights 3Health News:Indiana Boudoir Photographer Begins Shooting Breast Cancer Charity Calendar 2
(Date:7/10/2014)... 10, 2014   Ventana Medical Systems, Inc.  (Ventana), ... has entered into an agreement with Merck KGaA, Darmstadt, ... Serono in the United States ... Merck KGaA,s biopharmaceutical division on the development and commercialization ... using Ventana,s proprietary diagnostic assays. In alignment with Merck ...
(Date:7/10/2014)... 10, 2014 CVS Caremark Corporation (NYSE: ... approved a quarterly dividend of $0.275 (27.5 cents) per share ... August 1, 2014, to holders of record on July 21, ... Caremark is dedicated to helping people on their path to ... the United States . Through the company,s more ...
(Date:1/15/2014)... 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting ... China,s orthopedic instrument industry has ... size rising from 3.28 billion yuan in 2006 to ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3
... Sunpeaks Ventures, Inc. (OTCBB: SNPK) (PINKSHEETS: SNPK) (the ... Healthcare Distribution Specialist, LLC ("HDS") are pleased to announce ... Vitamin & Sports Nutrition Expo to be held at ... Florida on July 15-17, 2012.  As part of the ...
... announced today the Clinical Laboratory Responsibility Pledge, a ... ethical business practices in the medication monitoring industry. ... adheres and to which the company challenges every ... adopt. (Logo: http://photos.prnewswire.com/prnh/20120203/LA47138LOGO ) ...
Cached Medicine Technology:Sunpeaks Ventures to Participate in ECRM Conference and Expo 2Sunpeaks Ventures to Participate in ECRM Conference and Expo 3Millennium Laboratories Announces Laboratory Responsibility Pledge 2Millennium Laboratories Announces Laboratory Responsibility Pledge 3
... therapeutic benefits of controlled compression to minimize ... pain. The cuff is anatomically designed to ... The Ankle Cryo/Cuff is one-size for adults ... size.,All Cryo/Cuffs can be ordered as a ...
SCD Sequential Compression System Intermittent Pneumatic Compression...
Comfor™ Cast Boot - Rocker Sole - Closed Toe...
... cast boot specially lasted for fiberglass ... rocker sole for easy ambulation! ,The ... narrow last so it fits better ... and with our stretchable upper, a ...
Medicine Products: