Navigation Links
Asthma Meds Likely Safe During Pregnancy: Study
Date:1/20/2012

By Serena Gordon
HealthDay Reporter

FRIDAY, Jan. 20 (HealthDay News) -- A new study found no statistically significant link between asthma medication use during pregnancy and common birth defects.

However, the study did find a positive association between some rare birth defects and mothers with asthma, and potentially with their medication use. But, the researchers couldn't tease out whether the problem was a loss of oxygen from less than well-controlled asthma or an effect of medications.

"Worsening asthma is a risk to the mom and the fetus. Hypoxia (a lack of oxygen) we know is a problem for a developing fetus. And, the potential risk they found here is very small. Even if it turns out to be a true increase, the risk is so small. This study raises more questions than it answers," said Dr. Natalie Meirowitz, chief of the division of maternal fetal medicine at Long Island Jewish Medical Center in New Hyde Park, N.Y.

What's most important, she said, is that expectant mothers with asthma don't just stop their medications. "That's really a problem, and then they end up needing more medication," she said.

Findings from the study were published online Jan. 16, ahead of February print publication in Pediatrics.

Between 4 percent and 12 percent of expectant mothers have asthma, according to background information in the article. Current guidelines recommend that women keep taking their asthma medications during pregnancy.

There are two main types of asthma medications: bronchodilators (also known as rescue medication) and anti-inflammatories, which include inhaled and oral steroids, as well as several other medications. Anti-inflammatory medications are generally used long term to help control asthma symptoms.

For the study, the researchers compared nearly 2,900 infants born with birth defects to more than 6,700 babies born with no birth defects. Mothers of these infants were asked to recall their medication use one month before and during pregnancy.

For most birth defects, the researchers found no statistically significant associations between asthma medication use and the development of birth defects.

They did, however, find a positive association between asthma medication use and certain rare birth defects. The risk of isolated esophageal atresia -- an abnormality of the esophagus -- was more than doubled in women who used bronchodilators. The risk of isolated anorectal atresia -- a malformed anus -- was more than doubled with maternal anti-inflammatory use. And, the risk of omphalocele -- a defect in the abdominal wall -- was more than quadrupled for either type of asthma medication.

But, the authors wrote, the "observed associations may be chance findings or may be the result of maternal asthma severity and related hypoxia rather than the medication use."

They added that it's also important to keep these findings in context. The rate of these birth defects ranged from 1.2 to 4.6 per 10,000 births. So, even a four-fold increase in the risk of having one of these defects results in far less than a 1 percent chance for any individual woman and her child.

"As obstetricians, we need to pay attention to this, but it's really important to oxygenate mom. We really need to make sure that there's oxygen flowing freely between mom and baby," said Dr. Mary Rosser, an obstetrician with Montefiore Medical Center in New York City.

Also, Rosser pointed out that there was a lot that wasn't known about the expectant mothers. The authors weren't able to assess the severity of their asthma. They also didn't know anything about the medication doses.

Asthma expert Dr. Jennifer Appleyard agreed with Rosser and Meirowitz. "They really couldn't tease apart what was the medicine and what was the asthma," she said.

"You need to treat the asthma. There's more risk to uncontrolled asthma than a slight possible risk of a rare birth defect," said Appleyard, the chief of allergy and immunology at St. John Hospital and Medical Center in Detroit.

"No matter what type of patient you're treating -- expectant mom or not -- the goal is to treat patients with the minimum amount of medication necessary," she added.

Rosser and Meirowitz said that, ideally, women should visit their obstetrician/gynecologist before getting pregnant to review their medication use and to make sure that their asthma is well controlled.

More information

Learn more about asthma during pregnancy from the American College of Allergy, Asthma and Immunology.

SOURCES: Jennifer Appleyard, M.D., chief, allergy and immunology, St. John Hospital and Medical Center, Detroit, Mich.; Mary Rosser, M.D., obstetrician and gynecologist, Montefiore Medical Center, New York City; Natalie Meirowitz, M.D., chief, division of maternal fetal medicine, Long Island Jewish Medical Center, New Hyde Park, N.Y.; February 2012 Pediatrics


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Rapid Infant Growth Linked to Asthma in Study
2. Accelerated infant growth increases risk of future asthma symptoms in children
3. Children Born by C-Section at Slightly Higher Asthma Risk
4. Study Offers Clues to Why Some Dont Benefit From Asthma Drugs
5. A large subgroup of mild-to-moderate asthma is persistently non-eosinophilic
6. Overweight 7-Year-Olds Face Higher Risk of Asthma
7. Salk discovery may lead to safer treatments for asthma, allergies and arthritis
8. WTC First Responders More Likely to Have Asthma: Study
9. Asthma Drugs in Pregnancy Might Pose Risk for Kids
10. Work in cells, animals, patients reveals toxins role in asthma
11. Improved medication use could reduce severe asthma attacks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Asthma Meds Likely Safe During Pregnancy: Study
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... Fla. (PRWEB) , ... June 24, 2016 , ... Global ... Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition ... Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this year’s ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... DUBLIN , June 27, 2016 Jazz ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... proposed acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... 11:59 p.m. (Eastern Daylight Time). As previously ... entered into a definitive merger agreement under which Jazz ...
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
Breaking Medicine Technology: