Astellas/GlaxoSmithKline's Vesicare Has Advantages Over Pfizer's Detrol LA/Detrusitol XL in Reducing Episodes of Urge Urinary In...( Superior Side-Effect Profile Earns...),Health

Superior Side-Effect Profile Earns Vesicare Gold Standard Status Over Sales-Leading Detrol LA/Detrusitol XL, According to a New Report from

Decision Resources

WALTHAM, Mass., April 3, 2008 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that a drug's effect on the reduction of urge urinary incontinence episodes (and the resulting improvement in a patient's quality of life) is the attribute that most influences urologists' prescribing decisions in the treatment of urge urinary incontinence. Clinical data and expert opinion show that Astellas/GlaxoSmithKline's Vesicare has advantages in this attribute over the market sales leader, Pfizer's Detrol LA/ Detrusitol XL.

The new report entitled Urge Urinary Incontinence: Commercial Windfall Awaits the Treatment That Offers Significant Improvement in Dryness Rates finds that a drug offering a greater reduction in the number of urge urinary incontinence episodes per week over Detrol LA/Detrusitol XL would earn a 25 percent patient share in this market. The report also finds that, although Detrol LA/Detrusitol XL is the sales leader in the urge urinary market, the current and future gold standard treatment for the indication is Vesicare.

At doses that provide superior efficacy, clinical data and expert opinion indicate that Vesicare is superior to Detrol LA/Detrusitol XL and its successor, Pfizer's Toviaz, in its side-effect profile -- particularly on rates of dry mouth, an important cause for discontinuation of therapy.

"We do not expect any therapy under development for urge urinary incontinence to displace Vesicare as the clinical gold standard treatment," said Cindy Mundy, Ph.D., principal director at Decision Resources. "While some therapies in development for this indication hold promise, most of them earned inferior scores in efficacy, safety and tolerabil
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