Navigation Links
Associations linking weight to breast cancer survival vary by race/ethnicity
Date:10/28/2012

SAN DIEGO An extreme body mass index or high waist-to-hip ratio, both measures of body fat, increased risk for mortality among patients with breast cancer, but this association varied by race/ethnicity, according to recently presented data.

Marilyn L. Kwan, Ph.D., a research scientist in the Kaiser Permanente Northern California Division of Research in Oakland, Calif., presented these results at the Fifth AACR Conference on The Science of Cancer Health Disparities, held here Oct. 27-30, 2012.

Prior research has shown racial/ethnic differences in survival after a breast cancer diagnosis, particularly among non-Latina whites and African-Americans, according to Kwan. However, reasons for these differences in survival are not clear, and researchers have hypothesized that body size at the time of breast cancer diagnosis might play a role.

"The majority of studies among primarily non-Latina white populations on obesity before a diagnosis of breast cancer have found that increased weight is associated with poorer survival, yet few studies have examined if this association holds true within the major minority groups of African-Americans, Latinas and Asians and whether differences in obesity might explain racial/ethnic differences in survival," Kwan said.

She and her colleagues collected data from 12,025 female patients with breast cancer from the California Breast Cancer Survivorship Consortium. Body mass index (BMI) information was available for 11,351 women including 6,044 non-Latina whites, 1,886 African-Americans, 1,451 Asian-Americans, 1,864 Latinas and 106 others.

"Overall, we found that patients with breast cancer who were underweight, extremely obese or had high levels of abdominal body fat had the worst survival," Kwan said.

In fact, those women classified as underweight had a 47 percent increased risk for overall mortality compared with normal-weight women. Women classified as morbidly obese had a 43 percent increased risk for overall mortality. In addition, women with the highest waist-to-hip ratio (highest level of abdominal fat) had a 30 percent increased risk for overall mortality and a 36 percent increased risk for breast cancer mortality compared with those with the smallest waist-to-hip ratios.

When looking further at mortality within racial/ethnic groups, the researchers found that associations differed by race/ethnicity.

"Among non-Latina white women, being underweight and morbidly obese at breast cancer diagnosis was associated with worse survival, yet this relationship was not found in the other racial/ethnic groups," Kwan said. "Instead, African-American women and Asian-American women with larger waist-to-hip ratios had poorer survival, an observation not seen in non-Latina white women and Latina women."

Latina women had an elevated risk for mortality only among those considered morbidly obese. According to Kwan, this study supports the common lifestyle recommendation to maintain a healthy weight throughout life, but she pointed out that the long-term impact of weight on survival after breast cancer might not be the same in all patients.


'/>"/>
Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Researchers develop secure protocol for linking data registries for HPV surveillance
2. Tree nut consumption associated with lower body weight and lower prevalence of health risks
3. Even Preschoolers View the Overweight Negatively
4. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
5. Overweight Pregnant Women at Higher Risk for Complications
6. Can weight loss help African-American breast cancer survivors?
7. Guidelines say diet, exercise, weight control improve odds after cancer diagnosis
8. Slow-growing babies more likely in normal-weight women; Less common in obese pregnancies
9. Healthy Weight Loss May Also Cut Your Cancer Risk
10. In Moms Eyes, Overweight Toddler May Not Be
11. IUD Use Tied to Modest Weight Loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... Houston, TX (PRWEB) , ... June 26, 2017 , ... Antoine Dental Center ... the gold standard in tooth replacement and act as a support for prosthetic teeth, such ... fuses with the existing bone and becomes a sturdy, lasting new root for the tooth. ...
(Date:6/26/2017)... ... June 26, 2017 , ... ... recent review of government data released by the United Soybean Board. , ... Maryland’s soybean farmers have increased their productivity on less land per bushel, the ...
(Date:6/26/2017)... ... June 26, 2017 , ... ... and consumers are seeing lots of red these days. According to recent estimates, ... that result from medical coding errors(1). Some studies point to Electronic Health Records ...
(Date:6/25/2017)... ... June 25, 2017 , ... FCPX LUT Vintage Volume 2 for ... look. FCPX LUT Vintage Volume 2 contains 60 different color-grade presets, giving editors multiple ... vignettes and blurs to single out subjects, plus much more. FCPX LUT Vintage Volume ...
(Date:6/25/2017)... , ... June 25, 2017 , ... An increase in ... growing foliage and plants, and along with that; a humdinger of an allergy season. ... it also means an increase in misery-causing grass and weed pollen. , “Our ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... 14, 2017  In 2016, Embodied Labs ... pitch competition and came away with $25,000 in seed-fund ... by Forbes as "entering the life of another" and ... teaching "empathy to medical professionals in an entirely new ... named a finalist for the Department of Education,s EdSimChallenge, ...
(Date:6/10/2017)... , June 9, 2017  Shane K. Burchfield, DPM, is recognized ... excellence as a Podiatrist in Alabama . ... Family First Foot Care. He brings over 20 years of experience, ... management and healthcare, to his role. ... Care, PC is pleased to welcome you to his ...
(Date:6/8/2017)... Responding to Heath Ledger,s father,s recent call for ... Chris Cornell in May, the mental health watchdog group, ... psychiatric drug side effects search engine ... risks. The father of the late actor ... has called for tighter rules on prescription drugs. Speaking at ...
Breaking Medicine Technology: