Navigation Links
Associations linking weight to breast cancer survival vary by race/ethnicity
Date:10/28/2012

SAN DIEGO An extreme body mass index or high waist-to-hip ratio, both measures of body fat, increased risk for mortality among patients with breast cancer, but this association varied by race/ethnicity, according to recently presented data.

Marilyn L. Kwan, Ph.D., a research scientist in the Kaiser Permanente Northern California Division of Research in Oakland, Calif., presented these results at the Fifth AACR Conference on The Science of Cancer Health Disparities, held here Oct. 27-30, 2012.

Prior research has shown racial/ethnic differences in survival after a breast cancer diagnosis, particularly among non-Latina whites and African-Americans, according to Kwan. However, reasons for these differences in survival are not clear, and researchers have hypothesized that body size at the time of breast cancer diagnosis might play a role.

"The majority of studies among primarily non-Latina white populations on obesity before a diagnosis of breast cancer have found that increased weight is associated with poorer survival, yet few studies have examined if this association holds true within the major minority groups of African-Americans, Latinas and Asians and whether differences in obesity might explain racial/ethnic differences in survival," Kwan said.

She and her colleagues collected data from 12,025 female patients with breast cancer from the California Breast Cancer Survivorship Consortium. Body mass index (BMI) information was available for 11,351 women including 6,044 non-Latina whites, 1,886 African-Americans, 1,451 Asian-Americans, 1,864 Latinas and 106 others.

"Overall, we found that patients with breast cancer who were underweight, extremely obese or had high levels of abdominal body fat had the worst survival," Kwan said.

In fact, those women classified as underweight had a 47 percent increased risk for overall mortality compared with normal-weight women. Women classified as morbidly obese had a 43 percent increased risk for overall mortality. In addition, women with the highest waist-to-hip ratio (highest level of abdominal fat) had a 30 percent increased risk for overall mortality and a 36 percent increased risk for breast cancer mortality compared with those with the smallest waist-to-hip ratios.

When looking further at mortality within racial/ethnic groups, the researchers found that associations differed by race/ethnicity.

"Among non-Latina white women, being underweight and morbidly obese at breast cancer diagnosis was associated with worse survival, yet this relationship was not found in the other racial/ethnic groups," Kwan said. "Instead, African-American women and Asian-American women with larger waist-to-hip ratios had poorer survival, an observation not seen in non-Latina white women and Latina women."

Latina women had an elevated risk for mortality only among those considered morbidly obese. According to Kwan, this study supports the common lifestyle recommendation to maintain a healthy weight throughout life, but she pointed out that the long-term impact of weight on survival after breast cancer might not be the same in all patients.


'/>"/>
Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Researchers develop secure protocol for linking data registries for HPV surveillance
2. Tree nut consumption associated with lower body weight and lower prevalence of health risks
3. Even Preschoolers View the Overweight Negatively
4. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
5. Overweight Pregnant Women at Higher Risk for Complications
6. Can weight loss help African-American breast cancer survivors?
7. Guidelines say diet, exercise, weight control improve odds after cancer diagnosis
8. Slow-growing babies more likely in normal-weight women; Less common in obese pregnancies
9. Healthy Weight Loss May Also Cut Your Cancer Risk
10. In Moms Eyes, Overweight Toddler May Not Be
11. IUD Use Tied to Modest Weight Loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, ... journal articles published in Emergency Medicine Practice and Pediatric Emergency Medicine ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® ... Group (TGIG), has initiated cultivation and processing operations at its production facility, and ... Nevada. , Puradigm is the manufacturer of a complete system of proactive air ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated testing ... With this clearance, Roche is the first IVD company ... for sepsis risk assessment and management. PCT ... PCT levels in blood can aid clinicians in assessing ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
Breaking Medicine Technology: