Navigation Links
Association found between high cholesterol and breast cancer
Date:7/4/2014

This news release is available in Spanish.

Barcelona, 4 July 2014: An association between high blood cholesterol and breast cancer has been found in a study of more than 1 million patients over a 14 year time period in the UK. The research will be presented today at Frontiers in CardioVascular Biology (FCVB) 2014 in Barcelona, Spain. The meeting is organised by the Council on Basic Cardiovascular Science of the European Society of Cardiology (ESC) in collaboration with 13 European cardiovascular science societies.

http://spo.escardio.org/SessionDetails.aspx?eevtid=65&sessId=13301&subSessId=3494

Dr Rahul Potluri, founder of the ACALM Study Unit and lead author, said: "Our preliminary study suggests that women with high cholesterol in their blood may be at greater risk of getting breast cancer. It raises the possibility of preventing breast cancer with statins, which lower cholesterol, but as this is a primitive study, significant time and research is needed before this idea can be tested."

Over the past few years, population studies have suggested an association between obesity and breast cancer. Last year a study in mice concluded that lowering circulating cholesterol or interfering with its metabolism may be used to prevent or treat breast cancer.1

Dr Potluri said: "We have a general principle that obesity is linked to breast cancer and a study in mice suggested that this may be because of cholesterol. We decided to investigate whether there was any association between hyperlipidaemia, which is high cholesterol essentially, and breast cancer."

The researchers conducted a retrospective analysis of more than 1 million patients across the UK between 2000 and 2013 from the Algorithm for Comorbidities, Associations, Length of stay and Mortality (ACALM) clinical database. There were 664,159 women and of these, 22 938 had hyperlipidaemia and 9 312 had breast cancer. Some 530 women with hyperlipidaemia developed breast cancer.

The researchers used a statistical model to study the association between hyperlipidaemia and breast cancer. They found that having hyperlipidaemia increased the risk of breast cancer by 1.64 times (95% confidence interval 1.50-1.79).

Dr Potluri said: "We found that women with high cholesterol had a significantly greater chance of developing breast cancer. This was an observational study so we can't conclude that high cholesterol causes breast cancer but the strength of this association warrants further investigation."

He added: "A prospective study that monitors the risk of breast cancer in women with and without high cholesterol is needed to confirm what we observed. If the connection between high cholesterol and breast cancer is validated, the next step would be to see if lowering cholesterol with statins can reduce the risk of developing cancer."

Dr Potluri continued: "Statins are cheap, widely available and relatively safe. We are potentially heading towards a clinical trial in 10-15 years to test the effect of statins on the incidence of breast cancer. If such a trial is successful, statins may have a role in the prevention of breast cancer especially in high risk groups, such as women with high cholesterol."

He concluded: "While our study was preliminary, our results are promising. We found a significant association between having high cholesterol and developing breast cancer that needs to be explored in more depth. Caution is needed when interpreting our results because while we had a large study population, our analysis was retrospective and observational with inherent limitations. That said, the findings are exciting and further research in this field may have a big impact on patients several years down the line.'

Please note Spanish version is available for this Press Release

Reference

1Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science. 2013 Nov 29;342(6162):1094-8. doi:10.1126/science.1241908.

Did you want to tweet about our congress? - if you do, please use the official #FCVBCongress hashtag! Thank you

Note to Editors

About FCVB

Frontiers in CardioVascular Biology (FCVB) is a comprehensive basic science conference organised every two years by the ESC Council on Basic Cardiovascular Science, whose mission is to enhance the importance of basic science to clinical cardiology. FCVB 2014 was organised in collaboration with 13 European cardiovascular science societies.

About the European Society of Cardiology (ESC)

The European Society of Cardiology (ESC) represents more than 80 000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe.

Information for journalists attending FCVB 2014

  • If you have any question or request regarding interview opportunities, please contact:

    ESC Press Office - Alice Prieto

    press@escardio.org
    Tel: +336 22 41 84 92 (off site support number)

  • FCVB 2014 takes place in Barcelona, Spain, on 4 6 July 2014 at the Palau de Congressos de Catalunya.

    Please note that this year the ESC Congress 2014 will also take place in Barcelona, at FIRA Gran Via from 30 August 3 September 2014. http://www.escardio.org/congresses/esc-2014/Pages/welcome.aspx

    You can already register on-line as press: http://www.escardio.org/congresses/esc-2014/registration/Pages/press-registration.aspx

  • Look here for the current programme at a glance: http://www.escardio.org/congresses/frontiers-in-cardiovascular-biology-2014/Documents/programme-at-a-glance.pdf

  • For full details of a session, have a look at the Scientific Programme & Planner: http://spo.escardio.org/default.aspx?eevtid=65

  • On-site Press registration process:

    o Free registration applies to press representatives upon receipt of valid credentials and a fully completed embargo form.

    o Credential: either your ID press card or letter of assignment with proof of 3 published articles

    o Press registration is not available to Industry or its Public Relations representatives, event management, marketing or communications representatives

    o The decision of the ESC Press Office is final regarding all press registration requests.

    o When your registration as press will be validated you will be given a press badge and the press kit.


    '/>"/>


  • Contact: ESC Press Office
    press@escardio.org
    33-622-418-492
    European Society of Cardiology
    Source:Eurekalert  

    Related medicine news :

    1. Northwestern Medicine cardiologist is American Heart Association Physician of the Year
    2. STRIATUS/JBJS, Inc., announces American Diabetes Association participation in PRE-val
    3. Einstein & Montefiore present research at American Diabetes Association Scientific Sessions
    4. Infection Control Association honors study on CA-MRSA
    5. Mount Sinai presents important findings at the 2014 American Urological Association Meeting
    6. Prevent premature deaths from heart failure, urges the Heart Failure Association
    7. Buckley receives American Psychiatric Association award for mentorship
    8. Elsevier and the American Urological Association launch new journal: Urology Practice
    9. International Communication Association to hold Annual Conference in Seattle, Washington
    10. American Heart Association awards Loyola $438,740 for cardiac research
    11. The Republic of Tea’s Ron Rubin Selected as Leadership Award Winner by Specialty Food Association
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    Related Image:
    Association found between high cholesterol and breast cancer
    (Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
    (Date:6/26/2016)... NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and ... to be personalized through a fitness app. The fitness app plans to fix the two ... currently only offer a one size fits all type program , They don’t ...
    (Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica Scruggs ... for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs surgery, ... Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, MD, ...
    (Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
    (Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
    Breaking Medicine News(10 mins):
    (Date:6/24/2016)... 24, 2016  Consumers have taken a more ... placed more emphasis on patient outcomes. ... in the pharmaceutical industry have evolved beyond just ... companies are focusing on becoming more patient-oriented across ... and services that improve health. ...
    (Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
    (Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
    Breaking Medicine Technology: