Navigation Links
Assessing the quality of phase I clinical trial abstracts
Date:10/21/2008

velopment focus of the ENA symposia. There remains room for improvement in both conferences for improving abstract quality and we believe this may be achieved by adopting guidelines for reporting on phase 1 clinical trials."

Dr Ho and his colleagues have drawn up a list of what they believe should be included in any guidelines on reporting phase I trials. The following are items that are absolutely essential:

  • Description of dose-limiting toxicity encountered on study
  • Conclusion explicitly states maximum tolerated doses (MTD) or residual disease (RD) or reason for early trial closure
  • Description of grade three toxicity and above that may be related to study drug
  • Description of drug delivery schedule or formulation
  • Number of patients on study
  • Title identifying study as dose finding or phase I
  • Pharmacokinetic analysis, if applicable

The following items should also be reported:

  • Explicit definition of primary end point or objective
  • Rationale for study
  • Pharmacodynamic results, if applicable
  • Current status of study
  • Information related to treatment cycles
  • Efficacy outcome of patients
  • Number of patients at each dose level
  • Tumour types of responders, if applicable

Dr Ho said: "We are not aware of any such guidelines in existence. We are hoping that our suggestions for guidelines can be validated further and then put into clinical use, for instance, as recommendations and reference guide to clinical researchers to help them with abstract writing, and maybe also as guidelines for conferences to evaluate abstracts being submitted."

Abstracts at both conferences improved in quality the more recently they were presented, possibly indicating that authors were becoming more aware of what information needed to be included.

'/>"/>
Contact: Emma Mason
wordmason@mac.com
41-227-612-105
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Diabetes Spectrum Reports a Study Assessing the i-port(R) Injection Port for Administration of Insulin
2. Financing Retiree Health Care: Assessing GASB 45 Estimates of Liabilities
3. Measurements Poor for Assessing Clinical Trials With Children
4. Extremely low dose CT coronary angiography shows promise in assessing cardiac function
5. MedPAC Again Fails to Evaluate Overall Economic Conditions in Assessing SNF Funding Requirements
6. Nurses Report Quality Health Benefits Key to Choosing an Employer
7. National Pharmacy Technician Day Celebrated with Focus on Quality -- Pharmacy Technician Certification Board (PTCB) Touts Importance of Certified Technicians
8. Death rate 70 percent lower at top-rated hospitals: HealthGrades annual hospital quality study
9. National Coalition for Quality Colorectal Cancer Screening and Care Conveys Concerns over CT Colonography
10. Health Care Management Thought Leaders Converge for Summit on Cost, Quality and Consumer Focus
11. 2008 Idaho Potato Harvest Forecast: Plentiful, High-Quality Spuds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... 2014 GranuFlo lawsuit ( http://www.thegranuflolawsuit.com ... NaturaLyte dialysis concentrate recall continue to mount in ... Court, District of Massachusetts, Bernstein Liebhard LLP reports. ... the U.S. Judicial Panel on Multidistrict Litigation (JPML) ... pending in the proceeding. In July, the Panel ...
(Date:8/23/2014)... August 23, 2014 "When men sit ... into contact with the dirty water inside the bowl, ... itself," said one of two inventors from Naugatuck, and ... we developed this protective device." , They developed the ... surfaces, including the water, bowl and seat. This minimizes ...
(Date:8/23/2014)... August 23, 2014 On Monday, August ... a data breach suffered by Community Health Systems, ... compromise of 4.5 million records containing Personally Identifiable Information ... According to Mandiant, who was engaged to investigate the ... an advanced group of cyber attackers based in China, ...
(Date:8/23/2014)... Pixel Film Studios, a leader of Final Cut Pro ... Vol.3, a customizable title tool for FCPX , ... dragging ProIntro Vol.3 in their timeline" says Christina Austin, CEO ... saver and i think our users will agree" , ProIntro ... made with Final Cut Pro X users in mind. Achieve ...
(Date:8/23/2014)... Wilmington, NC (PRWEB) August 23, 2014 ... across North Carolina. It’s no different in Wilmington, NC. ... Young adults are falling victim to drug and alcohol ... young people are looking to overcome substance abuse, but ... Finding an adolescent treatment facility can be a challenge ...
Breaking Medicine News(10 mins):Health News:GranuFlo Lawsuits Mount in Federal Litigation, as Filings Surpass 2,000, Bernstein Liebhard LLP Reports 2Health News:GranuFlo Lawsuits Mount in Federal Litigation, as Filings Surpass 2,000, Bernstein Liebhard LLP Reports 3Health News:GranuFlo Lawsuits Mount in Federal Litigation, as Filings Surpass 2,000, Bernstein Liebhard LLP Reports 4Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 2Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 3Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 4Health News:A new plugin was announced today, ProIntro Vol.3 from Pixel Film Studios for Final Cut Pro X 2Health News:Troubled Teens Wilmington Helpline Guides Adolescents to the Path of Recovery 2
... Medicine physicians are currently utilizing a new treatment option ... full dose of radiation therapy during breast conserving surgery. ... first have surgery then undergo approximately six weeks of ... have busy schedules or do not have access to ...
... human papillomavirus (HPV) vaccine doses over a longer period of ... levels that were comparable to the standard vaccine schedule, according ... JAMA , a theme issue on infectious disease and immunology. ... presented the findings of the study at a JAMA ...
... 769 men from across the United States recently diagnosed with ... the tumor or radiation poses no added risk of death. ... as the cancer,s progression and tumor growth are closely monitored ... the disease over time. None of the men, mostly ...
... created by the incomplete combustion of fossil fuels and ... their children, according to a new study. Researchers found ... birth, those children with high levels of a pollution ... of attention problems and anxiety/depression at ages 5 and ...
... For the first time in a human model, scientists have ... researchers can now develop better and more efficient drugs to ... new brain cells, however, until now it was not known ... published in the journal Molecular Psychiatry , researchers from ...
... , MONDAY, April 11 (HealthDay News) -- Progressive resistance training ... function better in daily life, researchers say. A team ... of available evidence and concluded that an adult can add ... increase their overall strength by 25 percent to 30 percent ...
Cached Medicine News:Health News:Radiation at time of lumpectomy may offer faster, more precise treatment for breast cancer patients 2Health News:Radiation at time of lumpectomy may offer faster, more precise treatment for breast cancer patients 3Health News:Lengthening dosing schedule of HPV vaccine may provide effective option for expanding use of vaccine 2Health News:Lengthening dosing schedule of HPV vaccine may provide effective option for expanding use of vaccine 3Health News:Closely monitoring low-risk prostate cancer, with biopsy, does not raise risk of death 2Health News:Closely monitoring low-risk prostate cancer, with biopsy, does not raise risk of death 3Health News:Prenatal exposure to certain pollutants linked to behavioral problems in young children 2Health News:New target for developing effective anti-depressants 2Health News:Progressive Weight Training Can Boost Seniors' Strength 2
(Date:8/22/2014)... 22, 2014 Research ... addition of the  "Global Operating Room Equipment ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,An operating ... environment in a healthcare facility used to ... technically advanced equipment, which ensures patient care ...
(Date:8/22/2014)... /CNW/ - On Aug. 20, at its annual meeting ... Association (CMA) voted on and approved a delegate resolution ... cannabis. Bedrocan Cannabis Corp., a leading Canadian licensed producer ... The CMA is quite right to point ... any plant material, including medicinal cannabis. While some patients, ...
(Date:8/22/2014)... , Aug. 22, 2014 Research and ... "Global and Chinese Intravenous Catheter Industry Report 2014" ... and Chinese Intravenous Catheter Industry Report 2014 is a ... the global intravenous catheter industry with a focus on ... overview of the industry including definitions, classifications, applications and ...
Breaking Medicine Technology:Global Operating Room Equipment Market 2014-2018: Key Vendors are Getinge, STERIS, Stykron and TRUMPF Medical Systems 2Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Global and Chinese Intravenous Catheter Industry Report 2014 2
... 2, 2012 CVS Caremark Corporation (NYSE: CVS ) ... months ended March 31, 2012. (Logo: http://photos.prnewswire.com/prnh/20090226/NE75914LOGO ... , Net revenues increased 19.9% to a record $30.8 ... , Retail Pharmacy segment same stores sales increased ...
... Ill., May 2, 2012  Celebrity chef Spike Mendelsohn knows all ... – especially for a person with acid reflux disease (ARD). ... Spike has also had to learn how to turn down ... awareness and understanding about the importance of managing heartburn symptoms ...
Cached Medicine Technology:CVS Caremark Reports Record First Quarter Results 2CVS Caremark Reports Record First Quarter Results 3CVS Caremark Reports Record First Quarter Results 4CVS Caremark Reports Record First Quarter Results 5CVS Caremark Reports Record First Quarter Results 6CVS Caremark Reports Record First Quarter Results 7CVS Caremark Reports Record First Quarter Results 8CVS Caremark Reports Record First Quarter Results 9CVS Caremark Reports Record First Quarter Results 10CVS Caremark Reports Record First Quarter Results 11CVS Caremark Reports Record First Quarter Results 12CVS Caremark Reports Record First Quarter Results 13CVS Caremark Reports Record First Quarter Results 14CVS Caremark Reports Record First Quarter Results 15CVS Caremark Reports Record First Quarter Results 16Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 2Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 3Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 4Chef Spike Mendelsohn Dishes on How to Turn Down the Heat on Acid Reflux Disease 5
Used for drainage and retrograde pyelogram. The spiral tip aids in negotiation of a tortuous or partially obstructed ureter. Supplied sterile in peel-open packages. Intended for one-time use....
Used for drainage and retrograde pyelogram. Supplied sterile in peel-open packages. Intended for one-time use....
Used for drainage and navigation of a tortuous ureter. The tapered tip eases placement as there are no edges to interfere with the ureteral orifice. Supplied sterile in peel-open packages. Intended f...
These flexible stone retrieval devices are reusable, 3 Fr in diameter, with a working length of either 60 cm or 115 cm...
Medicine Products: