Navigation Links
Assessing positive outcomes of phase III trials
Date:12/3/2010

t the news treatment in place of the standard treatment" and investigators should try to reach at least a clinically important difference that was specified in the protocol.

They also suggest that the FDA and EMEA "should define what constitute a positive trial based on the concept of establishing a meaningful clinical benefit for patients similar to those included in any given trial."

In an accompanying editorial, J. Jack Lee, Ph.D., of the M.D. Anderson Cancer Center, writes that this "excellent commentary" calls for a new drug approval paradigm and challenges both the medical and statistical communities to find a better way to assessing whether a drug really works.

Lee goes on to argue for the adoption of the Bayesian approach in contrast to the more conventional frequentist approach. "Statistics in medicine has passed through its infancy and childhood. As it moves into its adolescence, the growing pains of reconciling frequentist and Bayesian views continue," he writes. In his view, though, the "roadblocks" of the Bayesian approach, namely the notion of subjectivity and computation difficulty, have been overcome.

"The Bayesian approach is complementary to and can provide a superior alternative to the frequentist paradigm," Lee writes. "I encourage medical researchers to have an open mind, learn more about Bayesian methods, and apply them to provide a more accurate statistical assessment of the results in clinical trials."


'/>"/>

Contact: Kristine Crane
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers validate a new test for assessing childrens and teenagers fitness to prevent morbidity
2. Assessing the science behind health claims
3. For HIV-positive patients, delayed treatment a costly decision
4. Positive Attitude, Planning May Help Women Through Menopause
5. Positive psychological changes from meditation training linked to cellular health
6. Positive social traits trump bad health habits
7. Targeted therapy promising for HER2-positive metastatic breast cancer
8. New study finds positive return on investment for states that invest in quit smoking treatments
9. Study shows tranquil scenes have positive impact on brain
10. Survey of American women finds STD vaccine viewed positively
11. Penns Positive Psychology Center awards $2.9 million for research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... treated for the cancer Hodgkin lymphoma will be able ... researchers estimated their risk of premature menopause with different ... Journal of the National Cancer Institute , are based ... in England and Wales treated for the cancer over ... research has suggested that women with Hodgkin lymphoma who ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Human induced ... field of regenerative medicine because they can be coaxed ... don’t always act as anticipated. They sometimes mutate, develop ... in a new study recently published in STEM CELLS ... around this, simply by removing the material used to ...
(Date:8/22/2014)... Thompson HealthDay Reporter ... American health-care workers infected with the deadly Ebola virus ... been released from the Atlanta hospital where they have ... Dr. Kent Brantly, 33, was released from Emory ... hospital Tuesday. Her family said the 59-year-old woman is ...
(Date:8/22/2014)... 22, 2014 Goats are taking over Beverly ... attends the 10th annual Pre-Emmy Awards Boom Boom Room. Celebrities ... the best new products for kids on August 23 at ... and we’ll be encouraging them to #GoGoat for L.A. families ... to present our gentle, non-GMO goat milk foods to health-conscious ...
(Date:8/22/2014)... 2014 Being optimistic about the ... some foreign and domestic companies are speeding up ... and acquisitions. In 2012, Medtronic, Inc. acquired the ... Kanghui Holdings for USD 816 million; In Jan. ... makers-- Trauson Holdings Company Limited for HKD5.9 billion; ...
Breaking Medicine News(10 mins):Health News:Scientists map risk of premature menopause after cancer treatment 2Health News:Removing Programming Material After Inducing Stem Cells Could Improve Their Regeneration Ability 2Health News:Both U.S. Health-Care Workers Infected With Ebola Released From Hospital 2Health News:Both U.S. Health-Care Workers Infected With Ebola Released From Hospital 3Health News:#GoGoat with Kabrita at the Pre-Emmy Awards Boom Boom Room 2Health News:China Orthopedic Instrument Industry 2014- Global Industry Size, Share, Trend, Growth and Forecast 2017 2
... Host Free Webcast on Making a Smooth Transition to the ... Incorporated (NYSE: IRM ), the global leader in ... share tips during an upcoming Webcast for how healthcare providers ... , In this free, hour-long Webcast, attendees will learn the ...
... researcher says , THURSDAY, June 4 (HealthDay News) -- ... the world don,t perform as well as males in math. ... the United States and abroad that appears in the June 1 ... , "There are countries where the gender disparity in math ...
... June 4 /PRNewswire-FirstCall/ - MDS Inc. (TSX: MDS; NYSE: ... and services to the global life sciences markets, today ... financial results on Thursday, June 11, 2009. , The ... analysts with Stephen P. DeFalco, President and Chief Executive ...
... , , Proven Interoperability Solution Expands ... Carestream, Intergy RIS, Cloverleaf, Meditech RIS, McKesson, PowerScribe ... June 4 Healthcare IT workflow management pioneer ... its comprehensive suite of Enterprise digital imaging and ...
... plans reduce audit risk while ensuring accurate payments and compliance with ... a select few have ever wondered how to integrate Medicare Risk ... hear about the latest release from Storan Technologies Inc. ... of Merlin Medicare Risk Adjustment 6.0 (TM), a ...
... relief for pain, strengthening of immune systems and more , ... more research is showing that most illness, disease and other ... of the cellular immune system with essential nutrition. Key to ... nutrients and water. This is something that,s become more difficult ...
Cached Medicine News:Health News:Best Practices for Hospitals Moving to Electronic Medical Records 2Health News:Girls and Math: Blame the Culture, Not Ability 2Health News:Compressus Delivers Imaging Productivity & Efficiency Improvements in Next Generation MEDxConnect(TM) Workflow Management Solution 2Health News:Compressus Delivers Imaging Productivity & Efficiency Improvements in Next Generation MEDxConnect(TM) Workflow Management Solution 3Health News:Compressus Delivers Imaging Productivity & Efficiency Improvements in Next Generation MEDxConnect(TM) Workflow Management Solution 4Health News:St. Louis Firm Brings Medicare Risk Adjustment to iPhone 2Health News:Breakthrough Nanotechnology Delivers Safe, Nutrition-Packed Cellular Hydration 2Health News:Breakthrough Nanotechnology Delivers Safe, Nutrition-Packed Cellular Hydration 3
(Date:8/22/2014)... ITHACA, N.Y. , Aug. 22, 2014 /PRNewswire/ ... computed tomography (CT) imaging facility, is using the ... 4D and even 5D imaging to researchers and ... just launched, asks "What would YOU do if ... the possibility to researchers and explorers everywhere, from ...
(Date:8/22/2014)... 22, 2014 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: ... commercializes proprietary technologies and products for advanced microarray ... a Master Service Agreement to contract with a ... assays. During the initial phase of this agreement, ... working prototype of one of the customer,s assays, ...
(Date:8/21/2014)... AUSTIN, Texas , Aug. 21, 2014  Vermillion, ... company focused on gynecologic cancers and women,s health, has ... of Sales and Managed Markets. Ms. Bauzon ... traction and expanding payer coverage for laboratory services companies. ... most recently with PerkinElmer, Inc., where she held the ...
Breaking Medicine Technology:Cornell's X-ray Imaging Lab Director Uses Kickstarter Campaign to "Democratize" Advanced 3D Imaging 2SQI Diagnostics Contracted to Automate Pathogen Detection Assays 2SQI Diagnostics Contracted to Automate Pathogen Detection Assays 3Vermillion Appoints Holly B. Bauzon as VP of Sales and Managed Markets 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: