Navigation Links
Assembly of a protein degradation machine could lead to treatments in cancer, neurological diseases
Date:5/6/2013

ls. Chaperones act as a foreman for the two particles.

One of the findings in the new study is that in addition to acting as a molecular foreman for the two particles, chaperones also control when those two particles come together. Similarly, the scientists found more about the two particles.

The core particle has seven pockets while the regulatory particle has six tails that tuck into those pockets. When docked together, they turn on the proteasome's functionality.

"In the assembly process there is only one tail that actually determines how the core particle and regulatory particle bind together," Roelofs said. "That's surprising because there are six tails, but only one is needed to give specificity, and the docking into the pocket is controlled by the chaperone."

Roelofs believes that the findings may reveal new targets for anticancer drugs, as a chaperone in the human genes is involved in liver cancer. The proteasome inhibitor Bortezomib is used in the treatment of current cancers. Additionally, the information may advance cancer and neurological research by giving scientists new pathways to study and manipulate.

"This is pretty basic research," Roelofs said. "Understanding the basic mechanics can often lead to new pathways for improvement, which is essential when it comes to human health."

Scientists made the findings through a combination of techniques, including Cryo-electron microscopy, X-ray crystallography, yeast genetics, biochemical reconstitution assays and proteasome activity measurements. These techniques helped researchers observe the submicroscopic tails and complex tail-to-pocket binding process, as well as study the role of the chaperones in the core and regulatory particle process.


'/>"/>

Contact: Jeroen Roelofs
jroelofs@k-state.edu
785-532-3969
Kansas State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. World Health Assembly endorses new plan to increase global access to vaccines
2. EP Global Communications, Inc, EPGL Medical Begins Selling MPDD Devices, Singapore Distributor Secures First 1,000 Units Off Assembly Line
3. Warwick scientists uncover how checkpoint proteins bind chromosomes
4. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
5. Unusual protein helps regulate key cell communication pathway
6. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
7. RANK protein promotes the initiation, progression and metastasis of human breast cancer
8. Protein may represent a switch to turn off B cell lymphoma
9. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
10. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
11. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Wi (PRWEB) October 01, 2014 UP4 ... of UP4 WOMEN’S probiotic to The National Network to ... of October. This organization was chosen through nationwide polling ... website and social media outlets. , “We are ... receive a portion of every sale of UP4 Women’s ...
(Date:10/1/2014)... This weekend Pope Francis drew world-wide attention to the problem ... seniors in St. Peter's Square in the Vatican, he decried ... the elderly is as inhuman as that against children," Pope ... discarded, victims of an abandonment that is tantamount to hidden ... is hurting our world so much," he said. , His ...
(Date:10/1/2014)... Los Angeles, CA (PRWEB) October 01, 2014 ... buyer power score of 3.1 out of 5, ... freezer users include food and beverage manufacturers, food ... manufacturers. As a result of these users' diversity, ... growth. As such, rising industrial production, consumer spending ...
(Date:10/1/2014)... 01, 2014 Nearly a year-and-a-half after ... County District Court jury awarded him $4.75 million; Michael ... years old. Casper had been too sick to ... According to the Court Documents (District Court, Pueblo County ... a benign non-cancerous condition of his prostate, when he ...
(Date:9/30/2014)... (HealthDay News) -- There,s no genetic evidence that high ... a new study says. Some previous research had ... people against type 2 diabetes, raising the possibility of ... sugar disease. In this study, British researchers investigated ... focusing on genes that control blood levels of vitamin ...
Breaking Medicine News(10 mins):Health News:UP4 Probiotics Partners with The National Network to End Domestic Violence 2Health News:Pope Francis Shines New Spotlight on Neglect of Elderly, Survey Finds Elder Self-Neglect is a Growing and Hidden Problem in U.S. says NAPGCM 2Health News:Pope Francis Shines New Spotlight on Neglect of Elderly, Survey Finds Elder Self-Neglect is a Growing and Hidden Problem in U.S. says NAPGCM 3Health News:Industrial Freezers Procurement Category Market Research Report Now Available from IBISWorld 2Health News:Industrial Freezers Procurement Category Market Research Report Now Available from IBISWorld 3Health News:Industrial Freezers Procurement Category Market Research Report Now Available from IBISWorld 4Health News:Law Offices of D.R. Jones Client Wins 4.7 Million Dollar Verdict, Insurance Company Files Motion for a New Trial 2Health News:Law Offices of D.R. Jones Client Wins 4.7 Million Dollar Verdict, Insurance Company Files Motion for a New Trial 3Health News:Gene Study Finds No Proof Vitamin D Guards Against Type 2 Diabetes 2
... Mii amo, a destination spa,at Enchantment Resort, for ... the winter solstice on December 21. Activities include ... Native,American Program Director R.J. Joseph and special guest, ... Elder from the Blood Reserve,in Standoff, Alberta, Canada,s ...
... planned bequest comes at stem cell symposium, ANN ... retail pioneer A. Alfred Taubman announced a $22 million ... research institute aimed at,understanding, treating and preventing human disease., ... it again --,announcing that he will bequeath an additional ...
... a Man Wanted to Know But Was Afraid to ... 4.3 million babies born,in the U.S. each year but ... BEING DAD is a revealing, entertaining and inspirational DVD ... who,have recently gone through the pregnancy and delivery process. ...
... developed a magnetic resonance imaging (MRI)-based method for detecting and ... in patients who have undergone a procedure to treat atrial ... Oct. 7, 2008, issue of the Journal of the ... is an arrhythmia, or abnormal heart rhythm, that involves the ...
... (OTCBB:WYND), the ideas-to-revenues social media company, announced ... www.muveinc.com ), to create an interactive marketing ... corporate wellness program. Wyndstorm,s design project will ... use of wellness programs among employees via ...
... 7 The Catholic Health,Association of the United ... (CHI), Denver; Covenant Health Systems, Lexington, MA;,and Trinity ... effort to,raise awareness about global climate change., ... National Religious,Partnership for the Environment (NRPE) and the ...
Cached Medicine News:Health News:Mii amo Honors Winter Solstice With Traditional Native American Celebration December 18-21 2Health News:Alfred Taubman Announces New $22M Gift to U-M 2Health News:BEING DAD DVD Offers a Sneak Peek at Pregnancy From a Guy's Point of View 2Health News:Novel imaging approach may assist in predicting success of treatment for atrial fibrillation 2Health News: 3D Social Media Application Aims to Cut Workplace Obesity : Muve, Inc., Selects Social Media Developer Wyndstorm Corporation to Design Online Promotions for Corporate Wellness Program 2Health News: 3D Social Media Application Aims to Cut Workplace Obesity : Muve, Inc., Selects Social Media Developer Wyndstorm Corporation to Design Online Promotions for Corporate Wellness Program 3Health News:Catholic Health Organizations Launch Ministry-Wide Effort to Raise Awareness About Global Climate Change 2
(Date:9/30/2014)... Sept. 30, 2014 Arbor Pharmaceuticals, LLC. ... Global Markets Direct,s, ,Arbor Pharmaceuticals, LLC. - ... of the Arbor Pharmaceuticals, LLC.,s pharmaceutical research and ... on the current therapeutic developmental pipeline of Arbor ... stages, therapeutics assessment by drug target, mechanism of ...
(Date:9/30/2014)... DENVER , Sept. 30, 2014  According ... "the world of cancer clinical trials is going ... clinical trials and the work of the current ... these types of ,next generation, clinical trials, which ... tomorrow."  The company has been ...
(Date:9/30/2014)... , Sept. 30, 2014 A study ... (OCT), offered a new look at the composition of ... how physicians understand and treat the disease, a leading ... at Baptist Health Lexington between September 2010 and May ... the Journal of the American College of Cardiology ...
Breaking Medicine Technology:Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient 2
... Combination with CRESTOR (rosuvastatin calcium) Demonstrates Similar Lipid Effects ... ... Population, SAN FRANCISCO, June 7 ... type 2 diabetes,that were enrolled in a Phase III study showed ...
... the ADA,s Annual Scientific Sessions, SAN FRANCISCO, ... of the dose-finding study for its new,injectable diabetes ... American Diabetes Association,s (ADA) 68th Annual Scientific Sessions,meeting ... that AVE0010 was well tolerated and significantly,improved glycemic ...
Cached Medicine Technology:Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 2Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 3Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 4New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 2New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 3New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 4
DNA/RNA preparation in 8-multi channels...
... units with hydrophobic PTFE membranes,Millex filter ... ideal for the sterilizing filtration of ... and for sterilizing or clarifying organic ... filter units are available with different ...
... Bottled Water, The Simplicity personal water system ... currently use bottled water. In addition to ... store bottled water, your laboratory applications may ... be absorbed from containers and cause water ...
... of Type I ultrapure water, , Ultrapure ... System is designed to provide the "final ... by reverse osmosis, distillation or deionization. Super-Q ... which exceeds Type I ASTM/CAP/NCCLS specifications.,The Super-Q ...
Medicine Products: