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Aspirin use appears linked with improved survival after colon cancer diagnosis
Date:3/31/2014

HLA class I antigen-positive tumors. In contrast, in patients whose tumors had lost their HLA class I antigen expression, aspirin use did not change the outcome."

(JAMA Intern Med. Published online March 31, 2014. doi:10.1001/jamainternmed.2014.511. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Authors made conflict of interest disclosures. This work was supported by an unrestricted grant from the Sloos-Alandt family. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Commentary: Aspirin as Adjuvant Therapy for Stage III Colon Cancer.

In a related commentary, Alfred I. Neugut, M.D., Ph.D., of Columbia University, New York, writes: "When one sees a patient newly diagnosed as having cancer, after finishing the initial discussion and treatment plan, it is almost inevitable that the patient or a family member will inquire, "What else should he [or she] do?"

"For my own patients, I have so far not recommended aspirin [for colon cancer]. But I think based on current evidence, that if I personally had a stage III tumor, I would add aspirin to my FOLFOX (folinic acid-flourouracil-oxaliplatin) adjuvant therapy. And if I feel that way for myself, should I not convey that to my patients?" Neugut continues.

"But for now, as far as I am concerned, when a patient or a patient's spouse asks, "What else should he be doing, Doctor?" I will have a ready response," Neugut concludes.


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Contact: Gerrit Jan Liefers
g.j.liefers@lumc.nl
The JAMA Network Journals
Source:Eurekalert

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