Navigation Links
Aspirin at Bedtime Lowers Blood Pressure
Date:5/14/2008

No benefit seen for prehypertensive people in morning use, researchers report

WEDNESDAY, May 14 (HealthDay News) -- A daily aspirin can control prehypertension, but only if it is taken at bedtime, a Spanish study shows.

An aspirin taken every morning didn't lower the blood pressure of prehypertensive people, but the evening regimen did, Dr. Ramon C. Hermida reported Wednesday at the American Society of Hypertension annual meeting, in New Orleans.

A previous study by Hermida, who is director of bioengineering and chronobiology at the University of Vigo, showed the same beneficial effect of bedtime aspirin for people with moderately high blood pressure. The new report is the first study to show the drug's benefit -- although only when taken at night -- with prehypertension, defined as blood pressure just below the 140/90 level. Prehypertension is a known warning sign of future risk of heart disease, stroke and other cardiovascular problems.

Why aspirin should do its good work for blood pressure at night but not in the daytime is not clear, Hermida said. Research indicates that it can slow the production of hormones and other substances in the body that cause clotting, many of which are produced while the body is at rest.

The three-month study included 244 adults diagnosed with prehypertension. A third of them were advised to follow general rules of hygiene and diet designed to reduce blood pressure, another third were told to take a 100-milligram aspirin tablet every night at bedtime, and the final third were told to take the same aspirin dose on awakening.

Researchers monitored blood pressure levels at 20-minute intervals from 7 a.m. to 11 p.m. and at 30-minute intervals at night before the trial began and three months later.

Systolic blood pressure (the higher number in the 140/90 reading) dropped 5.4 points and diastolic pressure by 3.4 points for those taking aspirin before bedtime. No drop in blood pressure was found in those taking morning aspirin or following the general guidelines.

"There is some evidence that taking a variety of medications, including those for hypertension, at night is associated with greater blood pressure reduction than taking them in the morning," said Dr. Suzanne Oparil, president of the American Society for Hypertension. "I don't think we know why."

It's possible that there might be better absorption of the medication by the gastrointestinal tract at night, said Oparil, who is a professor of medicine at the University of Alabama at Birmingham.

"It's all a little bit speculative about why, but I think the observation is solid," she said.

In a statement, Hermida said the new findings "show us that we cannot underestimate the impact of the body's circadian rhythms."

"The beneficial effects of time-dependent administration of aspirin have until now been largely unknown in people with prehypertension," he said. "Personalizing treatment according to one's own rhythms gives us a new option to optimize blood pressure control and reduce the risk of cardiovascular disease down the line."

More information

Aspirin in all its aspects is described by the U.S. National Library of Medicine.



SOURCES: Suzanne Oparil, M.D., professor, medicine, University of Alabama at Birmingham; May 14, 2008, presentation, American Society of Hypertension annual meeting, New Orleans


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
2. AUDIO from Medialink and Bayer: Is Your Pain Reliever Undermining Your Aspirin Therapy?
3. AUDIO from Medialink and Bayer: Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained with Naproxen Sodium
4. New, No-Swallow Fasprin(R) Reduces Problems Associated with Daily Aspirin Regimen
5. Aspirin, Hormone Therapy Combo Can Shorten Lives of Prostate Cancer Patients
6. Aspirin Resistance Boosts Heart Risks in Cardiac Patients
7. Regular, long-term aspirin use reduces risk of colorectal cancer
8. Many stroke, heart attack patients may not benefit from aspirin
9. Women are treated less frequently than men with statins, aspirin and beta-blockers
10. Drugs like aspirin could reduce breast cancer and help existing sufferers
11. Corgenix to Exhibit AspirinWorks(R) Test at 2008 ACOFP Meeting in Denver
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Aspirin at Bedtime Lowers Blood Pressure
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... ... 24, 2016 , ... EB Medicine presented its first-ever “Issue ... conference in Ponte Vedra Beach, FL. The awards honor the outstanding work of ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
(Date:6/23/2016)... WAYNE, Pa. , June 23, 2016 ... provider, will launch its next generation clinical outcomes platform, Bracket ... DIA Meeting held on June 26 – 30, 2016 in ... 6.0, the first electronic Clinical Outcome Assessment product of its ... DIA Booth #715. Bracket eCOA 6.0 is a ...
Breaking Medicine Technology: